ECOP

EGFR-coamplified and overexpressed protein, also known as ECOP, is a human gene.

VOPP1
Identifiers
Aliases	VOPP1, ECOP, GASP, vesicular, overexpressed in cancer, prosurvival protein 1, WBP1L2, WBP1/VOPP1 family member, VOPP1 WW domain binding protein
External IDs	OMIM: 611915; MGI: 2141658; HomoloGene: 12772; GeneCards: VOPP1; OMA:VOPP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p11.2 Start 55,436,056 bp End 55,572,988 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B3 Start 57,704,792 bp End 57,802,144 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus beta cell ventricular zone lymph node stromal cell of endometrium pylorus epithelium of nasopharynx parotid gland lateral nuclear group of thalamus cecum Top expressed in neural layer of retina saccule otic placode lacrimal gland blood retinal pigment epithelium otic vesicle parotid gland medullary collecting duct seminal vesicula More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity Cellular component integral component of membrane integral component of organelle membrane endosome cytoplasmic vesicle membrane membrane cytoplasmic vesicle Biological process regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81552 232023 Ensembl ENSG00000154978 ENSMUSG00000037788 UniProt Q96AW1 Q8R1C3 RefSeq (mRNA) NM_001284282 NM_001284283 NM_001284284 NM_030796 NM_001321242 NM_001321243 NM_001321244 NM_001321246 NM_001321247 NM_001321248 NM_001321249 NM_001321250 NM_001321251 NM_146168 RefSeq (protein) NP_001271211 NP_001271212 NP_001271213 NP_001308171 NP_001308172 NP_001308173 NP_001308175 NP_001308176 NP_001308177 NP_001308178 NP_001308179 NP_001308180 NP_110423 NP_666280 Location (UCSC) Chr 7: 55.44 – 55.57 Mb Chr 6: 57.7 – 57.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Park S, James CD (2005). "ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner". Oncogene. 24 (15): 2495–502. doi:10.1038/sj.onc.1208496. PMID 15735698. S2CID 342531.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Brem H, Stojadinovic O, Diegelmann RF, et al. (2007). "Molecular Markers in Patients with Chronic Wounds to Guide Surgical Debridement". Mol. Med. 13 (1–2): 30–9. doi:10.2119/2006-00054.Brem. PMC 1869625. PMID 17515955.