ELOVL5

Elongation of very long chain fatty acids protein 5 is a protein that in humans is encoded by the ELOVL5 gene.

ELOVL5
Identifiers
Aliases	ELOVL5, HELO1, SCA38, dJ483K16.1, ELOVL fatty acid elongase 5
External IDs	OMIM: 611805; MGI: 1916051; HomoloGene: 41449; GeneCards: ELOVL5; OMA:ELOVL5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p12.1 Start 53,267,398 bp End 53,349,179 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 E1 Start 77,824,646 bp End 77,891,801 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula secondary oocyte lactiferous duct tibia skin of thigh trigeminal ganglion parietal pleura epithelium of nasopharynx spinal ganglia inferior ganglion of vagus nerve Top expressed in vestibular membrane of cochlear duct Paneth cell carotid body cumulus cell conjunctival fornix adrenal gland facial motor nucleus substantia nigra stria vascularis anterior horn of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transferase activity 3-oxo-arachidoyl-CoA synthase activity 3-oxo-cerotoyl-CoA synthase activity fatty acid elongase activity 3-oxo-lignoceronyl-CoA synthase activity very-long-chain 3-ketoacyl-CoA synthase activity Cellular component dendritic tree dendrite integral component of membrane cell projection endoplasmic reticulum membrane soma membrane endoplasmic reticulum integral component of endoplasmic reticulum membrane Biological process lipid metabolism fatty acid biosynthetic process linoleic acid metabolic process alpha-linolenic acid metabolic process fatty acid metabolic process unsaturated fatty acid biosynthetic process fatty acid elongation, polyunsaturated fatty acid very long-chain fatty acid biosynthetic process fatty acid elongation, monounsaturated fatty acid long-chain fatty-acyl-CoA biosynthetic process positive regulation of fatty acid biosynthetic process fatty acid elongation, saturated fatty acid sphingolipid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 60481 68801 Ensembl ENSG00000012660 ENSMUSG00000032349 UniProt Q9NYP7 Q8BHI7 RefSeq (mRNA) NM_021814 NM_001242828 NM_001242830 NM_001242831 NM_001301856 NM_134255 RefSeq (protein) NP_001229757 NP_001229759 NP_001229760 NP_001288785 NP_068586 NP_599016 Location (UCSC) Chr 6: 53.27 – 53.35 Mb Chr 9: 77.82 – 77.89 Mb PubMed search
Wikidata
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Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barragan I, Marcos I, Borrego S, Antiñolo G (2006). "Mutation screening of three candidate genes, ELOVL5, SMAP1 and GLULD1 in autosomal recessive retinitis pigmentosa". Int. J. Mol. Med. 16 (6): 1163–7. doi:10.3892/ijmm.16.6.1163. PMID 16273301.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.