ITM2A

ITM2A
Identifiers
Aliases	ITM2A, BRICD2A, E25A, integral membrane protein 2A
External IDs	OMIM: 300222; MGI: 107706; HomoloGene: 31269; GeneCards: ITM2A; OMA:ITM2A - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	79,367,667 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	106,446,982 bp
RNA expression pattern
	Top expressed in
	thymus; ; cartilage tissue; ; vena cava; ; subthalamic nucleus; ; internal globus pallidus; ; lateral nuclear group of thalamus; ; inferior ganglion of vagus nerve; ; lactiferous duct; ; ventral tegmental area; ; Epithelium of choroid plexus;
	Top expressed in
	calvaria; ; efferent ductule; ; condyle; ; fossa; ; human fetus; ; dermis; ; vas deferens; ; umbilical cord; ; endocardial cushion; ; Gonadal ridge;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; amyloid-beta binding;
Cellular component	membrane; integral component of membrane; Golgi apparatus; plasma membrane; extracellular exosome;
Biological process	plasma cell differentiation; immunoglobulin production; nervous system development; negative regulation of amyloid precursor protein biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9452
	16431
	ENSG00000078596
	ENSMUSG00000031239
	O43736
	Q61500
	NM_004867; NM_001171581
	NM_008409
	NP_001165052; NP_004858
	NP_032435
	Wikidata
View/Edit Human	View/Edit Mouse

Integral membrane protein 2A is a protein that in humans is encoded by the ITM2A gene.^[5]^[6]^[7]^[8]

Function

The protein encoded by this gene is involved in osteo- and chondrogenic cellular differentiation (the cells which are responsible for the development of bone and cartilage respectively).^[6]

ITM2A is also involved in activation of T-cells in the immune system^[9] and in myocyte differentiation.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078596 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031239 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pittois K, Wauters J, Bossuyt P, Deleersnijder W, Merregaert J (Mar 1999). "Genomic organization and chromosomal localization of the Itm2a gene". Mamm Genome. 10 (1): 54–6. doi:10.1007/s003359900942. PMID 9892734. S2CID 24117211.
^ ^a ^b Deleersnijder W, Hong G, Cortvrindt R, Poirier C, Tylzanowski P, Pittois K, Van Marck E, Merregaert J (Sep 1996). "Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins". J Biol Chem. 271 (32): 19475–82. doi:10.1074/jbc.271.32.19475. PMID 8702637.
^ "Entrez Gene: ITM2A integral membrane protein 2A".
^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (July 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
^ Kirchner J, Bevan MJ (July 1999). "Itm2a Is Induced during Thymocyte Selection and T Cell Activation and Causes Downregulation of Cd8 When Overexpressed in Cd4+Cd8+ Double Positive Thymocytes". J. Exp. Med. 190 (2): 217–28. doi:10.1084/jem.190.2.217. PMC 2195576. PMID 10432285.
^ Van den Plas D, Merregaert J (2004). "Constitutive overexpression of the integral membrane protein Itm2A enhances myogenic differentiation of C2C12 cells". Cell Biol. Int. 28 (3): 199–207. doi:10.1016/j.cellbi.2003.11.019. PMID 14984746. S2CID 28123188.

External links

ITM2A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078596 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031239 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9892734-5] Pittois K, Wauters J, Bossuyt P, Deleersnijder W, Merregaert J (Mar 1999). "Genomic organization and chromosomal localization of the Itm2a gene". Mamm Genome. 10 (1): 54–6. doi:10.1007/s003359900942. PMID 9892734. S2CID 24117211.

[pmid8702637-6] Deleersnijder W, Hong G, Cortvrindt R, Poirier C, Tylzanowski P, Pittois K, Van Marck E, Merregaert J (Sep 1996). "Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins". J Biol Chem. 271 (32): 19475–82. doi:10.1074/jbc.271.32.19475. PMID 8702637.

[entrez-7] "Entrez Gene: ITM2A integral membrane protein 2A".

[pmid9653160-8] Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (July 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.

[pmid10432285-9] Kirchner J, Bevan MJ (July 1999). "Itm2a Is Induced during Thymocyte Selection and T Cell Activation and Causes Downregulation of Cd8 When Overexpressed in Cd4+Cd8+ Double Positive Thymocytes". J. Exp. Med. 190 (2): 217–28. doi:10.1084/jem.190.2.217. PMC 2195576. PMID 10432285.

[pmid14984746-10] Van den Plas D, Merregaert J (2004). "Constitutive overexpression of the integral membrane protein Itm2A enhances myogenic differentiation of C2C12 cells". Cell Biol. Int. 28 (3): 199–207. doi:10.1016/j.cellbi.2003.11.019. PMID 14984746. S2CID 28123188.

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ITM2A

Contents

Function

References

Further reading

External links