Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-
Function
editNF-κ B response
edit
IKK-
Once activated, NF-
Epidermal differentiation
editIKK-
The zebrafish homolog of IKK-
Keratinocyte migration
editI
Activation of three major hydrogen peroxide-dependent pathways, EGF, FOXO1, and IKK-
Other cellular targets
editIKK-
Clinical significance
editInhibition of I
Mutations in IKK-
Decreased IKK-
Interactions
editIKK-
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000213341 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025199 – Ensembl, May 2017
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- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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κ B-Inducing Kinase and TAK1 and Inhibits NF-κ B Activation". Mol. Cell. Biol. 21 (21): 7207–17. doi:10.1128/MCB.21.21.7207-7217.2001. PMC 99896. PMID 11585904. - ^ Vig E, Green M, Liu Y, Yu KY, Kwon HJ, Tian J, Goebl MG, Harrington MA (March 2001). "SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity". J. Biol. Chem. 276 (11): 7859–66. doi:10.1074/jbc.M010399200. PMID 11096118.
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κ Bα Kinase". Mol. Cell. Biol. 28 (5): 1783–91. doi:10.1128/MCB.02380-06. PMC 2258775. PMID 18180283. - ^ a b Régnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M (July 1997). "Identification and characterization of an IkappaB kinase". Cell. 90 (2): 373–83. doi:10.1016/S0092-8674(00)80344-X. PMID 9244310. S2CID 16217708.
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κ B Kinase". Mol. Cell. Biol. 22 (10): 3549–61. doi:10.1128/MCB.22.10.3549-3561.2002. PMC 133790. PMID 11971985. - ^ Prajapati S, Verma U, Yamamoto Y, Kwak YT, Gaynor RB (January 2004). "Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity". J. Biol. Chem. 279 (3): 1739–46. doi:10.1074/jbc.M306273200. PMID 14585847.
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κ Bα and Iκ Bβ Regulates NF-κ B DNA Binding Properties". Mol. Cell. Biol. 18 (7): 4221–34. doi:10.1128/MCB.18.7.4221. PMC 109006. PMID 9632806. - ^ Devin A; Lin Y; Yamaoka S; Li Z; Karin M; Liu Zg (June 2001). "The
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External links
edit- Human CHUK genome location and CHUK gene details page in the UCSC Genome Browser.