Melanocortin 5 receptor (MC5R) is a protein that in humans is encoded by the MC5Rgene.[5][6] It is located on the chromosome 18 in the human genome.[6] When the MC5R was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.[7]
MC5R is heavily expressed in the preputial gland in mice (a modified sebaceous gland involved in pheromone production). MC5R deficiency in male mice decreases aggressive behavior, promotes defensive behavior and encourages other male mice to attack MC5R-deficient males through pheromonal signals.[17][18][19]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chhajlani V, Muceniece R, Wikberg JE (September 1993). "Molecular cloning of a novel human melanocortin receptor". Biochemical and Biophysical Research Communications. 195 (2): 866–73. doi:10.1006/bbrc.1993.2125. PMID8396929.
^Zhang L, Li WH, Anthonavage M, Pappas A, Rossetti D, Cavender D, Seiberg M, Eisinger M (June 2011). "Melanocortin-5 receptor and sebogenesis". Eur J Pharmacol. 660 (1): 202–206. doi:10.1016/j.ejphar.2010.10.100. PMID21215742.
Fathi Z, Iben LG, Parker EM (January 1995). "Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype". Neurochemical Research. 20 (1): 107–13. doi:10.1007/BF00995160. PMID7739752. S2CID20792213.
Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1994). "Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 68 (1–2): 79–81. doi:10.1159/000133895. PMID7956366.
Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P (April 1994). "Molecular cloning and characterization of the rat fifth melanocortin receptor". Biochemical and Biophysical Research Communications. 200 (2): 1007–14. doi:10.1006/bbrc.1994.1550. PMID8179577.
Chhajlani V (February 1996). "Distribution of cDNA for melanocortin receptor subtypes in human tissues". Biochemistry and Molecular Biology International. 38 (1): 73–80. PMID8932521.
Frändberg PA, Xu X, Chhajlani V (July 1997). "Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH". Biochemical and Biophysical Research Communications. 236 (2): 489–92. doi:10.1006/bbrc.1997.6994. PMID9240466.
Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I (January 1999). "Characterization of Agouti-related protein binding to melanocortin receptors". Molecular Endocrinology. 13 (1): 148–55. doi:10.1210/me.13.1.148. PMID9892020.
Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH (October 2001). "Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro". Journal of Medicinal Chemistry. 44 (22): 3665–72. doi:10.1021/jm010165y. PMID11606131.
Lapinsh M, Veiksina S, Uhlén S, Petrovska R, Mutule I, Mutulis F, Yahorava S, Prusis P, Wikberg JE (January 2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes". Molecular Pharmacology. 67 (1): 50–9. doi:10.1124/mol.104.002857. PMID15470082. S2CID13536417.
Lohoff FW, Berrettini WH (December 2005). "Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder". Psychiatric Genetics. 15 (4): 255–8. doi:10.1097/00041444-200512000-00007. PMID16314755. S2CID21170090.
"Melanocortin Receptors: MC5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-07-14. Retrieved 2008-12-05.
