RPA4

Replication protein A 30 kDa subunit is a protein that in humans is encoded by the RPA4 gene.

RPA4
Identifiers
Aliases	RPA4, HSU24186, replication protein A4
External IDs	OMIM: 300767; HomoloGene: 88820; GeneCards: RPA4; OMA:RPA4 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq21.33 Start 96,883,908 bp End 96,885,467 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle secondary oocyte buccal mucosa cell skin of hip visceral pleura parietal pleura granulocyte gonad bone marrow Achilles tendon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function single-stranded DNA binding DNA binding damaged DNA binding double-stranded DNA binding protein binding sequence-specific DNA binding G-rich strand telomeric DNA binding Cellular component DNA replication factor A complex nucleus nucleoplasm telomere chromatin condensed nuclear chromosome site of double-strand break Biological process nucleotide-excision repair DNA damage checkpoint signaling DNA replication DNA recombination DNA replication initiation nuclear DNA replication DNA repair cellular response to DNA damage stimulus G1/S transition of mitotic cell cycle telomere maintenance via recombination double-strand break repair via homologous recombination DNA topological change DNA unwinding involved in DNA replication base-excision repair DNA mismatch repair mitotic recombination telomere maintenance via telomerase reciprocal meiotic recombination heteroduplex formation positive regulation of helicase activity regulation of DNA damage checkpoint Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29935 n/a Ensembl ENSG00000204086 n/a UniProt Q13156 n/a RefSeq (mRNA) NM_013347 n/a RefSeq (protein) NP_037479 n/a Location (UCSC) Chr X: 96.88 – 96.89 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Further reading

• Wu X, Yang Z, Liu Y, Zou Y (2006). "Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage". Biochem. J. 391 (Pt 3): 473–80. doi:10.1042/BJ20050379. PMC 1276948. PMID 15929725.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Parker A, Gu Y, Mahoney W, et al. (2001). "Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair". J. Biol. Chem. 276 (8): 5547–55. doi:10.1074/jbc.M008463200. PMID 11092888.
• Amacker M, Hottiger M, Mossi R, Hübscher U (1997). "HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase". AIDS. 11 (4): 534–6. PMID 9084803.
• Li L, Lu X, Peterson CA, Legerski RJ (1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. 15 (10): 5396–402. doi:10.1128/mcb.15.10.5396. PMC 230789. PMID 7565690.