Strontium-89 (89
Sr
) is a radioactive isotope of strontium produced by nuclear fission, with a half-life of 50.57 days. It undergoes
| General | |
|---|---|
| Symbol | 89Sr |
| Names | strontium-89, 89Sr, Sr-89 |
| Protons (Z) | 38 |
| Neutrons (N) | 51 |
| Nuclide data | |
| Natural abundance | syn |
| Half-life (t1/2) | 50.57 d |
| Decay products | 89Y |
| Decay modes | |
| Decay mode | Decay energy (MeV) |
| Beta decay | 1.492[1] |
| Isotopes of strontium Complete table of nuclides | |
History
editStrontium-89 was first synthesized in 1937 by D. W. Stewart et al. at the University of Michigan; it was synthesized via irradiation of stable strontium (88Sr) with deuterons.[3] Biological properties and applications of strontium-89 were studied for the first time by Belgian scientist Charles Pecher.[4][5] Pecher filed a patent in May 1941 for the synthesis of strontium-89 and yttrium-86 using cyclotrons, and described the therapeutic use of strontium.[6]
Physiological effects and medical use
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Strontium belongs to the same periodic family as calcium (alkaline earth metals), and is metabolised in a similar fashion, preferentially targeting metabolically active regions of the bone. 89Sr is an artificial radioisotope used in the treatment of osseous (bony) metastases of bone cancer.[8][9]
In circumstances where cancer patients have widespread and painful bony metastases, the administration of 89Sr results in the delivery of beta particles directly to the area of bony problem, where calcium turnover is greatest.[10] Consequently, intravenous or intracavity administration of 89Sr may be helpful in the palliation of painful bony metastases, as it allows radiation to be targeted at metastatic lesions, inducing apoptosis of cells, membrane and protein damage. Subsequently, bone pain resulting from cytokine release at the site of lesions, bone-associated nerve compression and stretching of the periosteum may be reduced. Treatment with 89Sr has been particularly effective in patients with hormonally-resistant prostate cancer, often leading to a decreased requirement for opioid analgesics, an increase in time until further radiation is needed, and a decrease in tumour markers.
See also
edit- Isotopes of strontium
- Alpharadin, radium-223 with similar clinical use
References
edit- ^ Delacroix, D.; Guerre, J. P.; Leblanc, P.; Hickman, C. (1 January 2002). "Radionuclide and Radiation Protection Data Handbook 2002". Radiation Protection Dosimetry. 98 (1): 79. doi:10.1093/oxfordjournals.rpd.a006705. PMID 11916063.
- ^ Audi, Georges; Wapstra, Aaldert Hendrik; Thibault, Catherne; Blachot, Jean; Bersillon, Olivier (2003). "The NUBASE evaluation of nuclear and decay properties" (PDF). Nuclear Physics A. 729 (1): 3–128. Bibcode:2003NuPhA.729....3A. CiteSeerX 10.1.1.692.8504. doi:10.1016/j.nuclphysa.2003.11.001. Archived from the original (PDF) on 2011-07-20.
- ^ Parker, A. M.; Thoennessen, M. (2012). "Discovery of rubidium, strontium, molybdenum, and rhodium isotopes". Atomic Data and Nuclear Data Tables. 98 (4): 812–831. arXiv:1102.2388. Bibcode:2012ADNDT..98..812P. doi:10.1016/j.adt.2012.06.001.
- ^ Pecher, Charles (1941). "Biological Investigations with Radioactive Calcium and Strontium". Proceedings of the Society for Experimental Biology and Medicine. 46 (1): 86–91. doi:10.3181/00379727-46-11899. ISSN 0037-9727. S2CID 88173163.
- ^ Pecher, Charles (1942). Biological investigations with radioactive calcium and strontium; preliminary report on the use of radioactive strontium in the treatment of metastatic bone cancer. Vol. 2. University of California Publications in Pharmacology. pp. 117–150. OCLC 7837554.
- ^ US 2302470, Pecher, Charles, "Material and method for radiography", published 1941-05-14
- ^ "Strontium 89 (Metastron) treatment". QEH Birmingham. NHS. Retrieved 23 November 2015.
- ^ Halperin, Edward C.; Perez, Carlos A.; Brady, Luther W. (2008). Perez and Brady's principles and practice of radiation oncology. Lippincott Williams & Wilkins. pp. 1997–. ISBN 978-0-7817-6369-1. Retrieved 19 July 2011.
- ^ Bauman, Glenn; Charette, Manya; Reid, Robert; Sathya, Jinka (2005). "Radiopharmaceuticals for the palliation of painful bone metastases—a systematic review". Radiotherapy and Oncology. 75 (3): 258.E1–258.E13. doi:10.1016/j.radonc.2005.03.003. ISSN 0167-8140. PMID 16299924.
- ^ Mertens, W. C.; Filipczak, L. A.; Ben-Josef, E.; Davis, L. P.; Porter, A. T. (1998). "Systemic bone-seeking radionuclides for palliation of painful osseous metastases: current concepts". CA: A Cancer Journal for Clinicians. 48 (6): 361–374. doi:10.3322/canjclin.48.6.361. ISSN 0007-9235. PMID 9838899.