SEC62

Translocation protein SEC62 is a protein that in humans is encoded by the SEC62 gene.

SEC62
Identifiers
Aliases	SEC62, Dtrp1, HTP1, TLOC1, TP-1, SEC62 homolog, preprotein translocation factor
External IDs	OMIM: 602173; MGI: 1916526; HomoloGene: 2449; GeneCards: SEC62; OMA:SEC62 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q26.2 Start 169,966,635 bp End 169,998,373 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 A3 Start 30,847,024 bp End 30,875,412 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell superior vestibular nucleus pons parotid gland inferior ganglion of vagus nerve pars reticulata Brodmann area 23 cardia renal medulla pars compacta Top expressed in saccule otic placode facial motor nucleus seminal vesicula lobe of prostate lacrimal gland anterior horn of spinal cord epithelium of lens parotid gland supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor activity Cellular component integral component of membrane cytosol rough endoplasmic reticulum endoplasmic reticulum membrane membrane endoplasmic reticulum integral component of endoplasmic reticulum membrane Biological process protein transport posttranslational protein targeting to endoplasmic reticulum membrane cotranslational protein targeting to membrane signal transduction posttranslational protein targeting to membrane, translocation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7095 69276 Ensembl ENSG00000008952 ENSMUSG00000027706 UniProt Q99442 Q8BU14 RefSeq (mRNA) NM_003262 NM_027016 NM_001357528 RefSeq (protein) NP_003253 NP_081292 NP_001344457 Location (UCSC) Chr 3: 169.97 – 170 Mb Chr 3: 30.85 – 30.88 Mb PubMed search
Wikidata
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Function

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

Further reading

• Daimon M, Susa S, Kato T (2000). "Fine structure of the human translocation protein 1 (HTP1/TLOC1) gene". IUBMB Life. 48 (6): 619–24. doi:10.1080/713803565. PMID 10683767. S2CID 10297001.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Jung V, Kindich R, Kamradt J, et al. (2006). "Genomic and expression analysis of the 3q25-q26 amplification unit reveals TLOC1/SEC62 as a probable target gene in prostate cancer". Mol. Cancer Res. 4 (3): 169–76. doi:10.1158/1541-7786.MCR-05-0165. PMID 16547154.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.