(Translated by https://www.hiragana.jp/)
DMPX: Difference between revisions - Wikipedia Jump to content

DMPX: Difference between revisions

Add links
From Wikipedia, the free encyclopedia
Browse history interactively
← Previous edit
Content deleted Content added
VisualWikitext
Importing Wikidata short description: "Chemical compound"
m added wiki-link
 
Line 30: Line 30:
}}
}}


'''DMPX''' ('''3,7-dimethyl-1-propargylxanthine''') is a [[caffeine]] analog which displays affinity to A<sub>2</sub> [[adenosine receptor]]s, in contrast to the A<sub>1</sub> subtype receptors.<ref name=DMPX>{{cite journal | vauthors = Seale TW, Abla KA, Shamim MT, Carney JM, Daly JW | title = 3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs | journal = Life Sciences | volume = 43 | issue = 21 | pages = 1671–84 | date = 1988 | pmid = 3193854 | doi = 10.1016/0024-3205(88)90478-x }}</ref> DMPX had 28× and 15× higher potency than caffeine in blocking peripheral and central [[5′-(N-ethylcarboxamido)adenosine|NECA]]-responses. The locomotor stimulation caused by DMPX (ED<sub>50</sub> 10 ''μみゅー''mol/kg) was similarly higher than caffeine.<ref name=DMPX />
'''DMPX''' ('''3,7-dimethyl-1-propargylxanthine''') is a [[caffeine]] [[Structural analog|analog]] which displays affinity to A<sub>2</sub> [[adenosine receptor]]s, in contrast to the A<sub>1</sub> subtype receptors.<ref name=DMPX>{{cite journal | vauthors = Seale TW, Abla KA, Shamim MT, Carney JM, Daly JW | title = 3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs | journal = Life Sciences | volume = 43 | issue = 21 | pages = 1671–84 | date = 1988 | pmid = 3193854 | doi = 10.1016/0024-3205(88)90478-x }}</ref> DMPX had 28× and 15× higher potency than caffeine in blocking peripheral and central [[5′-(N-ethylcarboxamido)adenosine|NECA]]-responses. The locomotor stimulation caused by DMPX (ED<sub>50</sub> 10 ''μみゅー''mol/kg) was similarly higher than caffeine.<ref name=DMPX />


==See also==
==See also==

Latest revision as of 18:11, 15 May 2024

DMPX
Clinical data
ATC code
  • None
Identifiers
  • 3,7-Dimethyl-1-(2-propyn-1-yl)-3,7-dihydro-1H-purine-2,6-dione
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.162.258 Edit this at Wikidata
Chemical and physical data
FormulaC10H10N4O2
Molar mass218.216 g·mol−1
3D model (JSmol)
  • Cn2cnc(c2c1=O)n(C)c(=O)n1CC#C
  • InChI=1S/C10H10N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h1,6H,5H2,2-3H3
  • Key:IORPOFJLSIHJOG-UHFFFAOYSA-N

DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity to A2 adenosine receptors, in contrast to the A1 subtype receptors.[1] DMPX had 28× and 15× higher potency than caffeine in blocking peripheral and central NECA-responses. The locomotor stimulation caused by DMPX (ED50 10 μみゅーmol/kg) was similarly higher than caffeine.[1]

See also[edit]

References[edit]

  1. ^ a b Seale TW, Abla KA, Shamim MT, Carney JM, Daly JW (1988). "3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs". Life Sciences. 43 (21): 1671–84. doi:10.1016/0024-3205(88)90478-x. PMID 3193854.
Retrieved from "https://en.wikipedia.org/w/index.php?title=DMPX&oldid=1224007662"