ASAH2B: Difference between revisions

ASAH2B
Identifiers
Aliases	ASAH2B, ASAH2L, bA449O16.3, bA98I6.3, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B, ASAH2C, N-acylsphingosine amidohydrolase 2B
External IDs	GeneCards: ASAH2B; OMA:ASAH2B - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	50,816,495 bp
RNA expression pattern
	Top expressed in
	duodenum; ; islet of Langerhans; ; ganglionic eminence; ; superior frontal gyrus; ; liver; ; rectum; ; stromal cell of endometrium; ; prefrontal cortex; ; left adrenal gland; ; right adrenal gland;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	N-acylsphingosine amidohydrolase activity;
Cellular component	extracellular region;
Biological process	long-chain fatty acid biosynthetic process; sphingosine biosynthetic process; ceramide catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	653308
	n/a
	ENSG00000204147
	n/a
	P0C7U1
	n/a
	NM_001079516; NM_001321957; NM_001321958; NM_001321959; NM_001321960
	n/a
	NP_001072984; NP_001308886; NP_001308887; NP_001308888; NP_001308889
	n/a
	Wikidata
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Latest revision as of 10:28, 17 October 2022

Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene.^[3]^[4]

Clinical significance[edit]

ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients.^[3]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000204147 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics. 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805. S2CID 20156514.
^ Deloukas P, Earthrowl ME, Grafham DV, et al. (May 2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.

External links[edit]

Human ASAH2B genome location and ASAH2B gene details page in the UCSC Genome Browser.

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+{{Short description|Protein-coding gene in the species Homo sapiens}}
 {{Infobox_gene}}
-'''Neutral ceramidase B''' also known as '''non-lysosomal ceramidase B''' or '''N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B''' or '''ASAH2B''' is a [[ceramidase]] [[enzyme]] which in humans is encoded by the ASAH2B [[gene]].<ref name="pmid17334805">{{cite journal | vauthors = Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS | title = A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease | journal = Neurogenetics | volume = 8 | issue = 2 | pages = 111–20 |date=April 2007 | pmid = 17334805 | doi = 10.1007/s10048-007-0081-5 | s2cid = 20156514 | url = | issn = }}</ref><ref name="pmid15164054">{{cite journal | vauthors = Deloukas P, Earthrowl ME, Grafham DV | title = The DNA sequence and comparative analysis of human chromosome 10 | journal = Nature | volume = 429 | issue = 6990 | pages = 375–81 |date=May 2004 | pmid = 15164054 | doi = 10.1038/nature02462 | url = | issn = |display-authors=etal| doi-access = free }}</ref>
+'''Neutral ceramidase B''' also known as '''non-lysosomal ceramidase B''' or '''N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B''' or '''ASAH2B''' is a [[ceramidase]] [[enzyme]] which in humans is encoded by the ASAH2B [[gene]].<ref name="pmid17334805">{{cite journal | vauthors = Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS | title = A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease | journal = Neurogenetics | volume = 8 | issue = 2 | pages = 111–20 |date=April 2007 | pmid = 17334805 | doi = 10.1007/s10048-007-0081-5 | s2cid = 20156514 }}</ref><ref name="pmid15164054">{{cite journal | vauthors = Deloukas P, Earthrowl ME, Grafham DV | title = The DNA sequence and comparative analysis of human chromosome 10 | journal = Nature | volume = 429 | issue = 6990 | pages = 375–81 |date=May 2004 | pmid = 15164054 | doi = 10.1038/nature02462 | bibcode = 2004Natur.429..375D |display-authors=etal| doi-access = free }}</ref>
 ==Clinical significance==

Latest revision as of 10:28, 17 October 2022

Clinical significance[edit]

References[edit]

External links[edit]

Further reading[edit]