POLE3: Difference between revisions

POLE3
Identifiers
Aliases	POLE3, CHARAC17, CHRAC17, YBL1, p17, polymerase (DNA) epsilon 3, accessory subunit, DNA polymerase epsilon 3, accessory subunit, CHRAC2
External IDs	OMIM: 607267; MGI: 1933378; HomoloGene: 9694; GeneCards: POLE3; OMA:POLE3 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	113,410,675 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	62,443,305 bp
RNA expression pattern
	Top expressed in
	gonad; ; gastrocnemius muscle; ; granulocyte; ; monocyte; ; human penis; ; ganglionic eminence; ; muscle of thigh; ; rectum; ; ventricular zone; ; bone marrow;
	Top expressed in
	spermatocyte; ; ventricular zone; ; yolk sac; ; secondary oocyte; ; zygote; ; fetal liver hematopoietic progenitor cell; ; seminiferous tubule; ; morula; ; molar; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; DNA-directed DNA polymerase activity; nucleotidyltransferase activity; protein binding; protein heterodimerization activity; histone acetyltransferase activity;
Cellular component	epsilon DNA polymerase complex; nucleus; nucleoplasm;
Biological process	DNA replication; histone H3 acetylation; DNA biosynthetic process; G1/S transition of mitotic cell cycle; cellular response to DNA damage stimulus; CENP-A containing chromatin assembly; cellular response to gamma radiation; DNA replication initiation; telomere maintenance via semi-conservative replication;
	Sources:Amigo / QuickGO
Orthologs
	54107
	59001
	ENSG00000148229
	ENSMUSG00000028394
	Q9NRF9
	Q9JKP7
	NM_001278255; NM_017443
	NM_021498
	NP_001265184; NP_059139
	NP_067473
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 22:28, 9 September 2023

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.^[5]^[6]^[7]

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]^[7]

Interactions[edit]

POLE3 has been shown to interact with SMARCA5.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148229 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028394 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li Y, Pursell ZF, Linn S (Aug 2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.
^ ^a ^b Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Oct 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
^ ^a ^b "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)".

Further reading[edit]

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Bolognese F, Imbriano C, Caretti G, Mantovani R (2000). "Cloning and characterization of the histone-fold proteins YBL1 and YCL1". Nucleic Acids Res. 28 (19): 3830–8. doi:10.1093/nar/28.19.3830. PMC 110757. PMID 11000277.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148229 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028394 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10801849-5] Li Y, Pursell ZF, Linn S (Aug 2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.

[pmid10880450-6] Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Oct 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.

[entrez-7] "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)".

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=54107}}
+{{Infobox_gene}}
-'''DNA polymerase epsilon subunit 3''' is an [[enzyme]] that in humans is encoded by the ''POLE3'' [[gene]].<ref name="pmid10801849">{{cite journal | author = Li Y, Pursell ZF, Linn S | title = Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon | journal = J Biol Chem | volume = 275 | issue = 30 | pages = 23247–52 |date=Aug 2000 | pmid = 10801849 | pmc =  | doi = 10.1074/jbc.M002548200 }}</ref><ref name="pmid10880450">{{cite journal | author = Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD | title = HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins | journal = EMBO J | volume = 19 | issue = 13 | pages = 3377–87 |date=Oct 2000 | pmid = 10880450 | pmc = 313940 | doi = 10.1093/emboj/19.13.3377 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54107| accessdate = }}</ref>
+'''DNA polymerase epsilon subunit 3''' is an [[enzyme]] that in humans is encoded by the ''POLE3'' [[gene]].<ref name="pmid10801849">{{cite journal | vauthors = Li Y, Pursell ZF, Linn S | title = Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon | journal = J Biol Chem | volume = 275 | issue = 30 | pages = 23247–52 |date=Aug 2000 | pmid = 10801849 | doi = 10.1074/jbc.M002548200 | doi-access = free }}</ref><ref name="pmid10880450">{{cite journal | vauthors = Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD | title = HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins | journal = EMBO J | volume = 19 | issue = 13 | pages = 3377–87 |date=Oct 2000 | pmid = 10880450 | pmc = 313940 | doi = 10.1093/emboj/19.13.3377 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54107}}</ref>
+POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54107}}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54107| accessdate = }}</ref>
-}}
 ==Interactions==
-POLE3 has been shown to [[Protein-protein_interaction|interact]] with [[SMARCA5]].<ref name=pmid10880450 />
+POLE3 has been shown to [[Protein-protein interaction|interact]] with [[SMARCA5]].<ref name=pmid10880450 />
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
 *{{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
 *{{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  }}
-*{{cite journal  | author=Bolognese F, Imbriano C, Caretti G, Mantovani R |title=Cloning and characterization of the histone-fold proteins YBL1 and YCL1. |journal=Nucleic Acids Res. |volume=28 |issue= 19 |pages= 3830–8 |year= 2000 |pmid= 11000277 |doi=10.1093/nar/28.19.3830  | pmc=110757  }}
+*{{cite journal  | vauthors=Bolognese F, Imbriano C, Caretti G, Mantovani R |title=Cloning and characterization of the histone-fold proteins YBL1 and YCL1. |journal=Nucleic Acids Res. |volume=28 |issue= 19 |pages= 3830–8 |year= 2000 |pmid= 11000277 |doi=10.1093/nar/28.19.3830  | pmc=110757  }}
-*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Post SM, Tomkinson AE, Lee EY |title=The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. |journal=Nucleic Acids Res. |volume=31 |issue= 19 |pages= 5568–75 |year= 2003 |pmid= 14500819 |doi=10.1093/nar/gkg765  | pmc=206465  }}
+*{{cite journal  | vauthors=Post SM, Tomkinson AE, Lee EY |author3-link=Eva Y.-H. P. Lee |title=The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. |journal=Nucleic Acids Res. |volume=31 |issue= 19 |pages= 5568–75 |year= 2003 |pmid= 14500819 |doi=10.1093/nar/gkg765  | pmc=206465  }}
-*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
-*{{cite journal   |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465  | pmc=2734081 }}
+*{{cite journal   |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465  | pmc=2734081 |bibcode=2004Natur.429..369H }}
 *{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
-*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
+*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
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