FSCN1: Difference between revisions
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
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'''Fascin''' is a [[protein]] that in humans is encoded by the ''FSCN1'' [[gene]].<ref name="pmid8068206">{{cite journal | vauthors = Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI | title = cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein | journal = DNA Cell Biol | volume = 13 | issue = 8 | pages = 821–7 | date = Sep 1994 | pmid = 8068206 | doi = 10.1089/dna.1994.13.821 | url = https://zenodo.org/record/1235261 }}</ref><ref name="pmid10783262">{{cite journal | vauthors = Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J | title = Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes | journal = Genomics | volume = 65 | issue = 2 | pages = 146–56 | date = Jul 2000 | pmid = 10783262 | doi = 10.1006/geno.2000.6156 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6624}}</ref> |
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| require_manual_inspection = no |
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| update_protein_box = yes |
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| update_summary = yes |
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}} |
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== Interactions == |
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{{GNF_Protein_box |
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| image = PBB_Protein_FSCN1_image.jpg |
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| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dfc. |
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| PDB = {{PDB2|1dfc}} |
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| Name = Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) |
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| HGNCid = 11148 |
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| Symbol = FSCN1 |
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| AltSymbols =; p55; FLJ38511; SNL |
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| OMIM = 602689 |
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| ECnumber = |
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| Homologene = 48164 |
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| MGIid = 1352745 |
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| GeneAtlas_image1 = PBB_GE_FSCN1_201564_s_at_tn.png |
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| GeneAtlas_image2 = PBB_GE_FSCN1_210933_s_at_tn.png |
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| Function = {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}} {{GNF_GO|id=GO:0051015 |text = actin filament binding}} |
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| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} |
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| Process = {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0051017 |text = actin filament bundle formation}} |
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| Orthologs = {{GNF_Ortholog_box |
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| Hs_EntrezGene = 6624 |
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| Hs_Ensembl = ENSG00000075618 |
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| Hs_RefseqProtein = NP_003079 |
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| Hs_RefseqmRNA = NM_003088 |
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| Hs_GenLoc_db = |
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| Hs_GenLoc_chr = 7 |
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| Hs_GenLoc_start = 5598980 |
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| Hs_GenLoc_end = 5612805 |
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| Hs_Uniprot = Q16658 |
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| Mm_EntrezGene = 14086 |
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| Mm_Ensembl = ENSMUSG00000029581 |
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| Mm_RefseqmRNA = NM_007984 |
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| Mm_RefseqProtein = NP_032010 |
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| Mm_GenLoc_db = |
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| Mm_GenLoc_chr = 5 |
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| Mm_GenLoc_start = 143225496 |
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| Mm_GenLoc_end = 143238322 |
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| Mm_Uniprot = Q05DK3 |
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}} |
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}} |
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'''Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)''', also known as '''FSCN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6624| accessdate = }}</ref> |
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FSCN1 has been shown to [[Protein-protein interaction|interact]] with [[Low affinity nerve growth factor receptor]]<ref name=pmid12789270>{{cite journal | vauthors = Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B | title = Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin | journal = Oncogene | volume = 22 | issue = 23 | pages = 3616–23 | date = Jun 2003 | pmid = 12789270 | doi = 10.1038/sj.onc.1206561 | s2cid = 13116876 | doi-access = }}</ref> and [[PKC alpha]].<ref name=pmid14532112>{{cite journal | vauthors = Anilkumar N, Parsons M, Monk R, Ng T, Adams JC | title = Interaction of fascin and protein kinase C |
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{{PBB_Summary |
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| section_title = |
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| summary_text = |
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}} |
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==References== |
== References == |
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{{reflist}} |
{{reflist}} |
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==Further reading== |
== Further reading == |
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{{refbegin | 2}} |
{{refbegin | 2}} |
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* {{cite journal | vauthors = Dawson SJ, White LA | title = Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin | journal = J. Infect. | volume = 24 | issue = 3 | pages = 317–20 | year = 1992 | pmid = 1602151 | doi = 10.1016/S0163-4453(05)80037-4 }} |
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{{PBB_Further_reading |
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* {{cite journal | vauthors = Yamashiro-Matsumura S, Matsumura F | title = Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells | journal = J. Biol. Chem. | volume = 260 | issue = 8 | pages = 5087–97 | year = 1985 | doi = 10.1016/S0021-9258(18)89183-9 | pmid = 3886649 | doi-access = free }} |
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| citations = |
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*{{cite journal |
* {{cite journal | vauthors = Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L, Matsumura F, Kieff E, Birkenbach M | title = Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein | journal = J. Virol. | volume = 68 | issue = 11 | pages = 7320–8 | year = 1994 | pmid = 7933116 | pmc = 237173 | doi = 10.1128/JVI.68.11.7320-7328.1994}} |
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*{{cite journal | |
* {{cite journal|author5-link=Geraldine Pinkus | vauthors = Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E | title = Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein | journal = Am. J. Pathol. | volume = 148 | issue = 2 | pages = 593–600 | year = 1996 | pmid = 8579121 | pmc = 1861678 }} |
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*{{cite journal |
* {{cite journal | vauthors = Yamakita Y, Ono S, Matsumura F, Yamashiro S | title = Phosphorylation of human fascin inhibits its actin binding and bundling activities | journal = J. Biol. Chem. | volume = 271 | issue = 21 | pages = 12632–8 | year = 1996 | pmid = 8647875 | doi = 10.1074/jbc.271.21.12632 | doi-access = free }} |
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*{{cite journal |
* {{cite journal | vauthors = Lin XH, Grako KA, Burg MA, Stallcup WB | title = NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration | journal = Mol. Biol. Cell | volume = 7 | issue = 12 | pages = 1977–93 | year = 1997 | pmid = 8970159 | pmc = 276044 | doi = 10.1091/mbc.7.12.1977 }} |
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*{{cite journal |
* {{cite journal | vauthors = Ono S, Yamakita Y, Yamashiro S, Matsudaira PT, Gnarra JR, Obinata T, Matsumura F | title = Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin | journal = J. Biol. Chem. | volume = 272 | issue = 4 | pages = 2527–33 | year = 1997 | pmid = 8999969 | doi = 10.1074/jbc.272.4.2527 | doi-access =free }} |
||
*{{cite journal |
* {{cite journal | vauthors = Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, Said JW | title = Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation? | journal = Am. J. Pathol. | volume = 150 | issue = 2 | pages = 543–62 | year = 1997 | pmid = 9033270 | pmc = 1858289 }} |
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*{{cite journal |
* {{cite journal | vauthors = Ross R, Ross XL, Schwing J, Längin T, Reske-Kunz AB | title = The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells | journal = J. Immunol. | volume = 160 | issue = 8 | pages = 3776–82 | year = 1998 | doi = 10.4049/jimmunol.160.8.3776 | pmid = 9558080 | doi-access = free }} |
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*{{cite journal |
* {{cite journal | vauthors = Sonderbye L, Meehan S, Palsson R, Ahsan N, Ladefoged J, Langhoff E | title = Immunohistochemical study of actin binding protein (p55) in the human kidney | journal = Transplantation | volume = 65 | issue = 7 | pages = 1004–8 | year = 1998 | pmid = 9565110 | doi = 10.1097/00007890-199804150-00025 | doi-access = free }} |
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*{{cite journal |
* {{cite journal | vauthors = Kempf W, Levi E, Kamarashev J, Kutzner H, Pfeifer W, Petrogiannis-Haliotis T, Burg G, Kadin ME | title = Fascin expression in CD30-positive cutaneous lymphoproliferative disorders | journal = J. Cutan. Pathol. | volume = 29 | issue = 5 | pages = 295–300 | year = 2003 | pmid = 12100631 | doi = 10.1034/j.1600-0560.2002.290507.x | s2cid = 31623792 }} |
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*{{cite journal |
* {{cite journal | vauthors = Goncharuk VN, Ross JS, Carlson JA | title = Actin-binding protein fascin expression in skin neoplasia | journal = J. Cutan. Pathol. | volume = 29 | issue = 7 | pages = 430–8 | year = 2003 | pmid = 12139639 | doi = 10.1034/j.1600-0560.2002.290708.x | s2cid = 26565797 }} |
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*{{cite journal |
* {{cite journal | vauthors = Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, Sonzogni A, De Manzoni G, Terzi A, Durante E, Bresaola E, Pezzella F, Viale G | title = Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer | journal = Br. J. Cancer | volume = 88 | issue = 4 | pages = 537–47 | year = 2003 | pmid = 12592367 | pmc = 2377175 | doi = 10.1038/sj.bjc.6600731 }} |
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*{{cite journal |
* {{cite journal | vauthors = Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B | title = Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin | journal = Oncogene | volume = 22 | issue = 23 | pages = 3616–23 | year = 2003 | pmid = 12789270 | doi = 10.1038/sj.onc.1206561 | s2cid = 13116876 | doi-access = }} |
||
*{{cite journal |
* {{cite journal | vauthors = Bros M, Ross XL, Pautz A, Reske-Kunz AB, Ross R | title = The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer | journal = J. Immunol. | volume = 171 | issue = 4 | pages = 1825–34 | year = 2003 | pmid = 12902483 | doi = 10.4049/jimmunol.171.4.1825 | doi-access = free }} |
||
*{{cite journal |
* {{cite journal | vauthors = Anilkumar N, Parsons M, Monk R, Ng T, Adams JC | title = Interaction of fascin and protein kinase C |
||
*{{cite journal |
* {{cite journal | vauthors = Ishikawa R, Sakamoto T, Ando T, Higashi-Fujime S, Kohama K | title = Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro | journal = J. Neurochem. | volume = 87 | issue = 3 | pages = 676–85 | year = 2003 | pmid = 14535950 | doi = 10.1046/j.1471-4159.2003.02058.x | s2cid = 927239 | doi-access = }} |
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*{{cite journal | author=Pelosi G, Pastorino U, Pasini F, ''et al.'' |title=Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer. |journal=Br. J. Cancer |volume=88 |issue= 4 |pages= 537-47 |year= 2003 |pmid= 12592367 |doi= 10.1038/sj.bjc.6600731 }} |
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*{{cite journal | author=Shonukan O, Bagayogo I, McCrea P, ''et al.'' |title=Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin. |journal=Oncogene |volume=22 |issue= 23 |pages= 3616-23 |year= 2003 |pmid= 12789270 |doi= 10.1038/sj.onc.1206561 }} |
|||
*{{cite journal | author=Bros M, Ross XL, Pautz A, ''et al.'' |title=The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer. |journal=J. Immunol. |volume=171 |issue= 4 |pages= 1825-34 |year= 2003 |pmid= 12902483 |doi= }} |
|||
*{{cite journal | author=Anilkumar N, Parsons M, Monk R, ''et al.'' |title=Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility. |journal=EMBO J. |volume=22 |issue= 20 |pages= 5390-402 |year= 2004 |pmid= 14532112 |doi= 10.1093/emboj/cdg521 }} |
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*{{cite journal | author=Ishikawa R, Sakamoto T, Ando T, ''et al.'' |title=Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro. |journal=J. Neurochem. |volume=87 |issue= 3 |pages= 676-85 |year= 2003 |pmid= 14535950 |doi= }} |
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}} |
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{{refend}} |
{{refend}} |
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{{PDB Gallery|geneid=6624}} |
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{{gene-7-stub}} |
{{gene-7-stub}} |
Latest revision as of 02:47, 1 January 2024
Fascin is a protein that in humans is encoded by the FSCN1 gene.[5][6][7]
Interactions
[edit]FSCN1 has been shown to interact with Low affinity nerve growth factor receptor[8] and PKC alpha.[9]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000075618 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029581 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI (Sep 1994). "cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein". DNA Cell Biol. 13 (8): 821–7. doi:10.1089/dna.1994.13.821. PMID 8068206.
- ^ Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J (Jul 2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.
- ^ "Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)".
- ^ Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (Jun 2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270. S2CID 13116876.
- ^ Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (Oct 2003). "Interaction of fascin and protein kinase C
α : a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.
Further reading
[edit]- Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
- Yamashiro-Matsumura S, Matsumura F (1985). "Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells". J. Biol. Chem. 260 (8): 5087–97. doi:10.1016/S0021-9258(18)89183-9. PMID 3886649.
- Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L, Matsumura F, Kieff E, Birkenbach M (1994). "Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein". J. Virol. 68 (11): 7320–8. doi:10.1128/JVI.68.11.7320-7328.1994. PMC 237173. PMID 7933116.
- Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E (1996). "Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein". Am. J. Pathol. 148 (2): 593–600. PMC 1861678. PMID 8579121.
- Yamakita Y, Ono S, Matsumura F, Yamashiro S (1996). "Phosphorylation of human fascin inhibits its actin binding and bundling activities". J. Biol. Chem. 271 (21): 12632–8. doi:10.1074/jbc.271.21.12632. PMID 8647875.
- Lin XH, Grako KA, Burg MA, Stallcup WB (1997). "NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration". Mol. Biol. Cell. 7 (12): 1977–93. doi:10.1091/mbc.7.12.1977. PMC 276044. PMID 8970159.
- Ono S, Yamakita Y, Yamashiro S, Matsudaira PT, Gnarra JR, Obinata T, Matsumura F (1997). "Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin". J. Biol. Chem. 272 (4): 2527–33. doi:10.1074/jbc.272.4.2527. PMID 8999969.
- Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, Said JW (1997). "Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?". Am. J. Pathol. 150 (2): 543–62. PMC 1858289. PMID 9033270.
- Ross R, Ross XL, Schwing J, Längin T, Reske-Kunz AB (1998). "The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells". J. Immunol. 160 (8): 3776–82. doi:10.4049/jimmunol.160.8.3776. PMID 9558080.
- Sonderbye L, Meehan S, Palsson R, Ahsan N, Ladefoged J, Langhoff E (1998). "Immunohistochemical study of actin binding protein (p55) in the human kidney". Transplantation. 65 (7): 1004–8. doi:10.1097/00007890-199804150-00025. PMID 9565110.
- Kempf W, Levi E, Kamarashev J, Kutzner H, Pfeifer W, Petrogiannis-Haliotis T, Burg G, Kadin ME (2003). "Fascin expression in CD30-positive cutaneous lymphoproliferative disorders". J. Cutan. Pathol. 29 (5): 295–300. doi:10.1034/j.1600-0560.2002.290507.x. PMID 12100631. S2CID 31623792.
- Goncharuk VN, Ross JS, Carlson JA (2003). "Actin-binding protein fascin expression in skin neoplasia". J. Cutan. Pathol. 29 (7): 430–8. doi:10.1034/j.1600-0560.2002.290708.x. PMID 12139639. S2CID 26565797.
- Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, Sonzogni A, De Manzoni G, Terzi A, Durante E, Bresaola E, Pezzella F, Viale G (2003). "Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer". Br. J. Cancer. 88 (4): 537–47. doi:10.1038/sj.bjc.6600731. PMC 2377175. PMID 12592367.
- Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270. S2CID 13116876.
- Bros M, Ross XL, Pautz A, Reske-Kunz AB, Ross R (2003). "The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer". J. Immunol. 171 (4): 1825–34. doi:10.4049/jimmunol.171.4.1825. PMID 12902483.
- Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (2004). "Interaction of fascin and protein kinase C
α : a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112. - Ishikawa R, Sakamoto T, Ando T, Higashi-Fujime S, Kohama K (2003). "Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro". J. Neurochem. 87 (3): 676–85. doi:10.1046/j.1471-4159.2003.02058.x. PMID 14535950. S2CID 927239.