FSCN1: Difference between revisions

FSCN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DFC, 4GP0, 4GP3, 3P53, 4GOY, 4GOV, 3LLP
Identifiers
Aliases	FSCN1, FAN1, HSN, SNL, p55, fascin actin-bundling protein 1
External IDs	OMIM: 602689; MGI: 1352745; HomoloGene: 48164; GeneCards: FSCN1; OMA:FSCN1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	5,606,655 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	142,958,940 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; middle frontal gyrus; ; frontal pole; ; Brodmann area 10; ; C1 segment; ; ventricular zone; ; right frontal lobe; ; putamen; ; amygdala;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; abdominal wall; ; Rostral migratory stream; ; endothelial cell of lymphatic vessel; ; condyle; ; primitive streak; ; endocardial cushion; ; fossa; ; mandibular prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; actin filament binding; protein binding; actin binding; RNA binding; cadherin binding;
Cellular component	cytoplasm; cell projection; cell-cell junction; filopodium; ruffle; myelin sheath; stress fiber; microvillus; cell junction; microspike; cell projection membrane; actin cytoskeleton; podosome; extracellular exosome; cytoskeleton; growth cone; lamellipodium; filamentous actin; cytosol;
Biological process	regulation of microvillus assembly; establishment of apical/basal cell polarity; regulation of actin cytoskeleton organization; actin filament organization; cell motility; positive regulation of podosome assembly; actin filament bundle assembly; positive regulation of extracellular matrix disassembly; cell-cell junction assembly; microspike assembly; cell population proliferation; positive regulation of lamellipodium assembly; cell migration; positive regulation of filopodium assembly; actin cytoskeleton organization; anatomical structure morphogenesis; establishment or maintenance of cell polarity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6624
	14086
	ENSG00000075618
	ENSMUSG00000029581
	Q16658
	Q61553
	NM_003088
	NM_007984
	NP_003079
	NP_032010
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 02:47, 1 January 2024

Fascin is a protein that in humans is encoded by the FSCN1 gene.^[5]^[6]^[7]

Interactions

FSCN1 has been shown to interact with Low affinity nerve growth factor receptor^[8] and PKC alpha.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000075618 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029581 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI (Sep 1994). "cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein". DNA Cell Biol. 13 (8): 821–7. doi:10.1089/dna.1994.13.821. PMID 8068206.
^ Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J (Jul 2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.
^ "Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)".
^ Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (Jun 2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270. S2CID 13116876.
^ Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (Oct 2003). "Interaction of fascin and protein kinase Cαあるふぁ: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.

Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Yamashiro-Matsumura S, Matsumura F (1985). "Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells". J. Biol. Chem. 260 (8): 5087–97. doi:10.1016/S0021-9258(18)89183-9. PMID 3886649.
Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L, Matsumura F, Kieff E, Birkenbach M (1994). "Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein". J. Virol. 68 (11): 7320–8. doi:10.1128/JVI.68.11.7320-7328.1994. PMC 237173. PMID 7933116.
Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E (1996). "Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein". Am. J. Pathol. 148 (2): 593–600. PMC 1861678. PMID 8579121.
Yamakita Y, Ono S, Matsumura F, Yamashiro S (1996). "Phosphorylation of human fascin inhibits its actin binding and bundling activities". J. Biol. Chem. 271 (21): 12632–8. doi:10.1074/jbc.271.21.12632. PMID 8647875.
Lin XH, Grako KA, Burg MA, Stallcup WB (1997). "NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration". Mol. Biol. Cell. 7 (12): 1977–93. doi:10.1091/mbc.7.12.1977. PMC 276044. PMID 8970159.
Ono S, Yamakita Y, Yamashiro S, Matsudaira PT, Gnarra JR, Obinata T, Matsumura F (1997). "Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin". J. Biol. Chem. 272 (4): 2527–33. doi:10.1074/jbc.272.4.2527. PMID 8999969.
Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, Said JW (1997). "Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?". Am. J. Pathol. 150 (2): 543–62. PMC 1858289. PMID 9033270.
Ross R, Ross XL, Schwing J, Längin T, Reske-Kunz AB (1998). "The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells". J. Immunol. 160 (8): 3776–82. doi:10.4049/jimmunol.160.8.3776. PMID 9558080.
Sonderbye L, Meehan S, Palsson R, Ahsan N, Ladefoged J, Langhoff E (1998). "Immunohistochemical study of actin binding protein (p55) in the human kidney". Transplantation. 65 (7): 1004–8. doi:10.1097/00007890-199804150-00025. PMID 9565110.
Kempf W, Levi E, Kamarashev J, Kutzner H, Pfeifer W, Petrogiannis-Haliotis T, Burg G, Kadin ME (2003). "Fascin expression in CD30-positive cutaneous lymphoproliferative disorders". J. Cutan. Pathol. 29 (5): 295–300. doi:10.1034/j.1600-0560.2002.290507.x. PMID 12100631. S2CID 31623792.
Goncharuk VN, Ross JS, Carlson JA (2003). "Actin-binding protein fascin expression in skin neoplasia". J. Cutan. Pathol. 29 (7): 430–8. doi:10.1034/j.1600-0560.2002.290708.x. PMID 12139639. S2CID 26565797.
Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, Sonzogni A, De Manzoni G, Terzi A, Durante E, Bresaola E, Pezzella F, Viale G (2003). "Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer". Br. J. Cancer. 88 (4): 537–47. doi:10.1038/sj.bjc.6600731. PMC 2377175. PMID 12592367.
Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270. S2CID 13116876.
Bros M, Ross XL, Pautz A, Reske-Kunz AB, Ross R (2003). "The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer". J. Immunol. 171 (4): 1825–34. doi:10.4049/jimmunol.171.4.1825. PMID 12902483.
Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (2004). "Interaction of fascin and protein kinase Cαあるふぁ: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.
Ishikawa R, Sakamoto T, Ando T, Higashi-Fujime S, Kohama K (2003). "Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro". J. Neurochem. 87 (3): 676–85. doi:10.1046/j.1471-4159.2003.02058.x. PMID 14535950. S2CID 927239.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000075618 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029581 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8068206-5] Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI (Sep 1994). "cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein". DNA Cell Biol. 13 (8): 821–7. doi:10.1089/dna.1994.13.821. PMID 8068206.

[pmid10783262-6] Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J (Jul 2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.

[entrez-7] "Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)".

[pmid12789270-8] Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (Jun 2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270. S2CID 13116876.

[pmid14532112-9] Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (Oct 2003). "Interaction of fascin and protein kinase Cαあるふぁ: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.

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[2]

[3]

[4]

[5]

[6]

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[9]

@@ Line 1: / Line 1: @@
+{{cs1 config|name-list-style=vanc}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Fascin''' is a [[protein]] that in humans is encoded by the ''FSCN1'' [[gene]].<ref name="pmid8068206">{{cite journal | vauthors = Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI | title = cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein | journal = DNA Cell Biol | volume = 13 | issue = 8 | pages = 821–7 | date = Sep 1994 | pmid = 8068206 | doi = 10.1089/dna.1994.13.821 | url = https://zenodo.org/record/1235261 }}</ref><ref name="pmid10783262">{{cite journal | vauthors = Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J | title = Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes | journal = Genomics | volume = 65 | issue = 2 | pages = 146–56 | date = Jul 2000 | pmid = 10783262 | doi = 10.1006/geno.2000.6156 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6624}}</ref>
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
+== Interactions ==
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_FSCN1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dfc.
- | PDB = {{PDB2|1dfc}}
- | Name = Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
- | HGNCid = 11148
- | Symbol = FSCN1
- | AltSymbols =; p55; FLJ38511; SNL
- | OMIM = 602689
- | ECnumber =
- | Homologene = 48164
- | MGIid = 1352745
- | GeneAtlas_image1 = PBB_GE_FSCN1_201564_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_FSCN1_210933_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}} {{GNF_GO|id=GO:0051015 |text = actin filament binding}}
- | Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
- | Process = {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0051017 |text = actin filament bundle formation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6624
-    | Hs_Ensembl = ENSG00000075618
-    | Hs_RefseqProtein = NP_003079
-    | Hs_RefseqmRNA = NM_003088
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 7
-    | Hs_GenLoc_start = 5598980
-    | Hs_GenLoc_end = 5612805
-    | Hs_Uniprot = Q16658
-    | Mm_EntrezGene = 14086
-    | Mm_Ensembl = ENSMUSG00000029581
-    | Mm_RefseqmRNA = NM_007984
-    | Mm_RefseqProtein = NP_032010
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 143225496
-    | Mm_GenLoc_end = 143238322
-    | Mm_Uniprot = Q05DK3
-  }}
-}}
-'''Fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)''', also known as '''FSCN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6624| accessdate = }}</ref>
+FSCN1 has been shown to [[Protein-protein interaction|interact]] with [[Low affinity nerve growth factor receptor]]<ref name=pmid12789270>{{cite journal | vauthors = Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B | title = Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin | journal = Oncogene | volume = 22 | issue = 23 | pages = 3616–23 | date = Jun 2003 | pmid = 12789270 | doi = 10.1038/sj.onc.1206561 | s2cid = 13116876 | doi-access =  }}</ref> and [[PKC alpha]].<ref name=pmid14532112>{{cite journal | vauthors = Anilkumar N, Parsons M, Monk R, Ng T, Adams JC | title = Interaction of fascin and protein kinase Cαあるふぁ: a novel intersection in cell adhesion and motility | journal = EMBO J. | volume = 22 | issue = 20 | pages = 5390–402 | date = Oct 2003 | pmid = 14532112 | pmc = 213775 | doi = 10.1093/emboj/cdg521 }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+== References ==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
+* {{cite journal | vauthors = Dawson SJ, White LA | title = Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin | journal = J. Infect. | volume = 24 | issue = 3 | pages = 317–20 | year = 1992 | pmid = 1602151 | doi = 10.1016/S0163-4453(05)80037-4 }}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Yamashiro-Matsumura S, Matsumura F | title = Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells | journal = J. Biol. Chem. | volume = 260 | issue = 8 | pages = 5087–97 | year = 1985 | doi = 10.1016/S0021-9258(18)89183-9 | pmid = 3886649 | doi-access = free }}
-| citations =
-*{{cite journal  | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317-20 |year= 1992 |pmid= 1602151 |doi=  }}
+* {{cite journal | vauthors = Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L, Matsumura F, Kieff E, Birkenbach M | title = Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein | journal = J. Virol. | volume = 68 | issue = 11 | pages = 7320–8 | year = 1994 | pmid = 7933116 | pmc = 237173 | doi =  10.1128/JVI.68.11.7320-7328.1994}}
-*{{cite journal  | author=Yamashiro-Matsumura S, Matsumura F |title=Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells. |journal=J. Biol. Chem. |volume=260 |issue= 8 |pages= 5087-97 |year= 1985 |pmid= 3886649 |doi=  }}
+* {{cite journal|author5-link=Geraldine Pinkus | vauthors = Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E | title = Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein | journal = Am. J. Pathol. | volume = 148 | issue = 2 | pages = 593–600 | year = 1996 | pmid = 8579121 | pmc = 1861678 }}
-*{{cite journal  | author=Mosialos G, Yamashiro S, Baughman RW, ''et al.'' |title=Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein. |journal=J. Virol. |volume=68 |issue= 11 |pages= 7320-8 |year= 1994 |pmid= 7933116 |doi=  }}
+* {{cite journal | vauthors = Yamakita Y, Ono S, Matsumura F, Yamashiro S | title = Phosphorylation of human fascin inhibits its actin binding and bundling activities | journal = J. Biol. Chem. | volume = 271 | issue = 21 | pages = 12632–8 | year = 1996 | pmid = 8647875 | doi = 10.1074/jbc.271.21.12632 | doi-access = free }}
-*{{cite journal  | author=Duh FM, Latif F, Weng Y, ''et al.'' |title=cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein. |journal=DNA Cell Biol. |volume=13 |issue= 8 |pages= 821-7 |year= 1994 |pmid= 8068206 |doi=  }}
+* {{cite journal | vauthors = Lin XH, Grako KA, Burg MA, Stallcup WB | title = NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration | journal = Mol. Biol. Cell | volume = 7 | issue = 12 | pages = 1977–93 | year = 1997 | pmid = 8970159 | pmc = 276044 | doi = 10.1091/mbc.7.12.1977 }}
-*{{cite journal  | author=Mosialos G, Birkenbach M, Ayehunie S, ''et al.'' |title=Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein. |journal=Am. J. Pathol. |volume=148 |issue= 2 |pages= 593-600 |year= 1996 |pmid= 8579121 |doi=  }}
+* {{cite journal | vauthors = Ono S, Yamakita Y, Yamashiro S, Matsudaira PT, Gnarra JR, Obinata T, Matsumura F | title = Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin | journal = J. Biol. Chem. | volume = 272 | issue = 4 | pages = 2527–33 | year = 1997 | pmid = 8999969 | doi = 10.1074/jbc.272.4.2527 | doi-access =free  }}
-*{{cite journal  | author=Yamakita Y, Ono S, Matsumura F, Yamashiro S |title=Phosphorylation of human fascin inhibits its actin binding and bundling activities. |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12632-8 |year= 1996 |pmid= 8647875 |doi=  }}
+* {{cite journal | vauthors = Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, Said JW | title = Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation? | journal = Am. J. Pathol. | volume = 150 | issue = 2 | pages = 543–62 | year = 1997 | pmid = 9033270 | pmc = 1858289 }}
-*{{cite journal  | author=Lin XH, Grako KA, Burg MA, Stallcup WB |title=NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration. |journal=Mol. Biol. Cell |volume=7 |issue= 12 |pages= 1977-93 |year= 1997 |pmid= 8970159 |doi=  }}
+* {{cite journal | vauthors = Ross R, Ross XL, Schwing J, Längin T, Reske-Kunz AB | title = The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells | journal = J. Immunol. | volume = 160 | issue = 8 | pages = 3776–82 | year = 1998 | doi = 10.4049/jimmunol.160.8.3776 | pmid = 9558080 | doi-access = free }}
-*{{cite journal  | author=Ono S, Yamakita Y, Yamashiro S, ''et al.'' |title=Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2527-33 |year= 1997 |pmid= 8999969 |doi=  }}
+* {{cite journal | vauthors = Sonderbye L, Meehan S, Palsson R, Ahsan N, Ladefoged J, Langhoff E | title = Immunohistochemical study of actin binding protein (p55) in the human kidney | journal = Transplantation | volume = 65 | issue = 7 | pages = 1004–8 | year = 1998 | pmid = 9565110 | doi = 10.1097/00007890-199804150-00025 | doi-access = free }}
-*{{cite journal  | author=Pinkus GS, Pinkus JL, Langhoff E, ''et al.'' |title=Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation? |journal=Am. J. Pathol. |volume=150 |issue= 2 |pages= 543-62 |year= 1997 |pmid= 9033270 |doi=  }}
+* {{cite journal | vauthors = Kempf W, Levi E, Kamarashev J, Kutzner H, Pfeifer W, Petrogiannis-Haliotis T, Burg G, Kadin ME | title = Fascin expression in CD30-positive cutaneous lymphoproliferative disorders | journal = J. Cutan. Pathol. | volume = 29 | issue = 5 | pages = 295–300 | year = 2003 | pmid = 12100631 | doi = 10.1034/j.1600-0560.2002.290507.x | s2cid = 31623792 }}
-*{{cite journal  | author=Ross R, Ross XL, Schwing J, ''et al.'' |title=The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells. |journal=J. Immunol. |volume=160 |issue= 8 |pages= 3776-82 |year= 1998 |pmid= 9558080 |doi=  }}
+* {{cite journal | vauthors = Goncharuk VN, Ross JS, Carlson JA | title = Actin-binding protein fascin expression in skin neoplasia | journal = J. Cutan. Pathol. | volume = 29 | issue = 7 | pages = 430–8 | year = 2003 | pmid = 12139639 | doi = 10.1034/j.1600-0560.2002.290708.x | s2cid = 26565797 }}
-*{{cite journal  | author=Sonderbye L, Meehan S, Palsson R, ''et al.'' |title=Immunohistochemical study of actin binding protein (p55) in the human kidney. |journal=Transplantation |volume=65 |issue= 7 |pages= 1004-8 |year= 1998 |pmid= 9565110 |doi=  }}
+* {{cite journal | vauthors = Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, Sonzogni A, De Manzoni G, Terzi A, Durante E, Bresaola E, Pezzella F, Viale G | title = Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer | journal = Br. J. Cancer | volume = 88 | issue = 4 | pages = 537–47 | year = 2003 | pmid = 12592367 | pmc = 2377175 | doi = 10.1038/sj.bjc.6600731 }}
-*{{cite journal  | author=Tubb BE, Bardien-Kruger S, Kashork CD, ''et al.'' |title=Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes. |journal=Genomics |volume=65 |issue= 2 |pages= 146-56 |year= 2000 |pmid= 10783262 |doi= 10.1006/geno.2000.6156 }}
+* {{cite journal | vauthors = Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B | title = Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin | journal = Oncogene | volume = 22 | issue = 23 | pages = 3616–23 | year = 2003 | pmid = 12789270 | doi = 10.1038/sj.onc.1206561 | s2cid = 13116876 | doi-access =  }}
-*{{cite journal  | author=Kempf W, Levi E, Kamarashev J, ''et al.'' |title=Fascin expression in CD30-positive cutaneous lymphoproliferative disorders. |journal=J. Cutan. Pathol. |volume=29 |issue= 5 |pages= 295-300 |year= 2003 |pmid= 12100631 |doi=  }}
+* {{cite journal | vauthors = Bros M, Ross XL, Pautz A, Reske-Kunz AB, Ross R | title = The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer | journal = J. Immunol. | volume = 171 | issue = 4 | pages = 1825–34 | year = 2003 | pmid = 12902483 | doi = 10.4049/jimmunol.171.4.1825 | doi-access = free }}
-*{{cite journal  | author=Goncharuk VN, Ross JS, Carlson JA |title=Actin-binding protein fascin expression in skin neoplasia. |journal=J. Cutan. Pathol. |volume=29 |issue= 7 |pages= 430-8 |year= 2003 |pmid= 12139639 |doi=  }}
+* {{cite journal | vauthors = Anilkumar N, Parsons M, Monk R, Ng T, Adams JC | title = Interaction of fascin and protein kinase Cαあるふぁ: a novel intersection in cell adhesion and motility | journal = EMBO J. | volume = 22 | issue = 20 | pages = 5390–402 | year = 2004 | pmid = 14532112 | pmc = 213775 | doi = 10.1093/emboj/cdg521 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Ishikawa R, Sakamoto T, Ando T, Higashi-Fujime S, Kohama K | title = Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro | journal = J. Neurochem. | volume = 87 | issue = 3 | pages = 676–85 | year = 2003 | pmid = 14535950 | doi = 10.1046/j.1471-4159.2003.02058.x | s2cid = 927239 | doi-access =  }}
-*{{cite journal  | author=Pelosi G, Pastorino U, Pasini F, ''et al.'' |title=Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer. |journal=Br. J. Cancer |volume=88 |issue= 4 |pages= 537-47 |year= 2003 |pmid= 12592367 |doi= 10.1038/sj.bjc.6600731 }}
-*{{cite journal  | author=Shonukan O, Bagayogo I, McCrea P, ''et al.'' |title=Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin. |journal=Oncogene |volume=22 |issue= 23 |pages= 3616-23 |year= 2003 |pmid= 12789270 |doi= 10.1038/sj.onc.1206561 }}
-*{{cite journal  | author=Bros M, Ross XL, Pautz A, ''et al.'' |title=The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer. |journal=J. Immunol. |volume=171 |issue= 4 |pages= 1825-34 |year= 2003 |pmid= 12902483 |doi=  }}
-*{{cite journal  | author=Anilkumar N, Parsons M, Monk R, ''et al.'' |title=Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility. |journal=EMBO J. |volume=22 |issue= 20 |pages= 5390-402 |year= 2004 |pmid= 14532112 |doi= 10.1093/emboj/cdg521 }}
-*{{cite journal  | author=Ishikawa R, Sakamoto T, Ando T, ''et al.'' |title=Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro. |journal=J. Neurochem. |volume=87 |issue= 3 |pages= 676-85 |year= 2003 |pmid= 14535950 |doi=  }}
-}}
 {{refend}}
+{{PDB Gallery|geneid=6624}}
 {{gene-7-stub}}