Cyprodenate: Difference between revisions

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{{Short description|Chemical compound}}
{{drugbox
{{Drugbox
| Verifiedfields = changed
| UNII_Ref = {{fdacite|changed|FDA}}
| Watchedfields = changed
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| verifiedrevid = 444141768
⚫
| UNII = I44VIC13P8
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| verifiedrevid = 404002130
| IUPAC_name = 2-dimethylaminoethyl 3-cyclohexylpropanoate
| IUPAC_name = 2-dimethylaminoethyl 3-cyclohexylpropanoate
| image=Cyprodenate.svg
| image = Cyprodenate.svg
| width= 200
| width = 200

<!--Clinical data-->
| tradename =
| Drugs.com = {{drugs.com|international|cyprodenate}}
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| routes_of_administration =

<!--Identifiers-->
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| CAS_number_Ref = {{cascite|correct|??}}
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| CAS_number = 15585-86-1
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| ATC_prefix = N06BX04
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| PubChem = 71875
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 64892
| ChemSpiderID = 64892
| ChEMBL = 2106590
| InChI = 1/C13H25NO2/c1-14(2)10-11-16-13(15)9-8-12-6-4-3-5-7-12/h12H,3-11H2,1-2H3
| UNII_Ref = {{fdacite|correct|FDA}}
⚫
| smiles = O=C(OCCN(C)C)CCC1CCCCC1
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| UNII = I44VIC13P8
| InChIKey = MPOYJPINNSIHAK-UHFFFAOYAN
| KEGG_Ref = {{keggcite|correct|kegg}}
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| KEGG = D07764

<!--Chemical data-->
⚫
| C=13 | H=25 | N=1 | O=2
⚫
| smiles = CN(C)CCOC(=O)CCC1CCCCC1
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C13H25NO2/c1-14(2)10-11-16-13(15)9-8-12-6-4-3-5-7-12/h12H,3-11H2,1-2H3
| StdInChI = 1S/C13H25NO2/c1-14(2)10-11-16-13(15)9-8-12-6-4-3-5-7-12/h12H,3-11H2,1-2H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = MPOYJPINNSIHAK-UHFFFAOYSA-N
| StdInChIKey = MPOYJPINNSIHAK-UHFFFAOYSA-N
⚫
| CAS_number= 15585-86-1
⚫
| ATC_prefix= none
| ATC_suffix=
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| PubChem= 71875
| DrugBank=
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| KEGG_Ref = {{keggcite|correct|kegg}}
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| KEGG = D07764
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| C=13 | H=25 | N=1 | O=2
| molecular_weight = 227.34
| bioavailability=
| metabolism =
| elimination_half-life=
| excretion =
| pregnancy_category =
| legal_status =
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| routes_of_administration=
}}
}}


'''Cyprodenate''' ('''Actebral''') is a [[stimulant]] drug.<ref>Dormard Y, Levron JC, Le Fur JM. Pharmacokinetic study of maleate acid of 2-(N,N-dimethylaminoethanol-14C1)-cyclohexylpropionate (cyprodenate) and of N,N-dimethylaminoethanol-14C1 in animals. ''Arzneimittelforschung''. 1975 Feb;25(2):201-7.</ref> It was used for counteracting the effects of [[benzodiazepine]] tranquillizer drugs before the development of newer [[antidotes]] such as [[flumazenil]].<ref>Bobkov IuG, Morozov IS. Correction of psychodepressive effects of benzodiazepine tranquilizers by administration of psychostimulants. (Russian). ''Biulleten Eksperimental'noi Biologii i Meditsiny''. 1982 Oct;94(10):48-51.</ref> It produces [[dimethylethanolamine]] as a [[metabolite]], and so might be expected to produce [[nootropic]] effects.
'''Cyprodenate''' ('''Actebral''') is a [[stimulant]] drug.<ref>{{cite journal | vauthors = Dormard Y, Levron JC, Le Fur JM | title = Pharmacokinetic study of maleate acid of 2-(N,N-dimethylaminoethanol-14C1)-cyclohexylpropionate (cyprodenate) and of N,N-dimethylaminoethanol-14C1 in animals | journal = Arzneimittel-Forschung | volume = 25 | issue = 2 | pages = 201–7 | date = February 1975 | pmid = 1173033 }}</ref> It was used for counteracting the effects of [[benzodiazepine]] tranquillizer drugs before the development of newer [[antidotes]] such as [[flumazenil]].<ref>{{cite journal | vauthors = Bobkov I, Morozov IS | title = [Correction of psychodepressive effects of benzodiazepine tranquilizers by administration of psychostimulants] | language = English | journal = Biulleten' Eksperimental'noi Biologii I Meditsiny | volume = 94 | issue = 10 | pages = 48–51 | date = October 1982 | pmid = 6129008 | doi = 10.1007/BF00827201 | s2cid = 19153614 }}</ref> It produces [[dimethylethanolamine]] as a [[metabolite]].{{citation needed|date=September 2018}}


== See also ==
== See also ==
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== References ==
== References ==
{{Reflist}}
{{Reflist}}



{{Stimulants}}
{{Stimulants}}
{{Nootropics}}
{{Psychostimulants, agents used for ADHD and nootropics}}
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{{Cholinergics}}


{{Acetylcholine receptor modulators}}
{{Monoamine releasing agents}}

⚫
[[Category:Cholinergics]]
[[Category:Nootropics]]
[[Category:Nootropics]]
[[Category:Stimulants]]
[[Category:Stimulants]]
[[Category:Propionates]]
[[Category:Propionate esters]]
[[Category:Amines]]
[[Category:Dimethylamino compounds]]
[[Category:Prodrugs]]
[[Category:Prodrugs]]
[[Category:Cyclohexyl compounds]]




Latest revision as of 07:57, 25 March 2024

Cyprodenate
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 2-dimethylaminoethyl 3-cyclohexylpropanoate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.036.025 Edit this at Wikidata
Chemical and physical data
FormulaC13H25NO2
Molar mass227.348 g·mol−1
3D model (JSmol)
  • CN(C)CCOC(=O)CCC1CCCCC1
  • InChI=1S/C13H25NO2/c1-14(2)10-11-16-13(15)9-8-12-6-4-3-5-7-12/h12H,3-11H2,1-2H3 checkY
  • Key:MPOYJPINNSIHAK-UHFFFAOYSA-N checkY
  (verify)

Cyprodenate (Actebral) is a stimulant drug.[1] It was used for counteracting the effects of benzodiazepine tranquillizer drugs before the development of newer antidotes such as flumazenil.[2] It produces dimethylethanolamine as a metabolite.[citation needed]

See also[edit]

References[edit]

  1. ^ Dormard Y, Levron JC, Le Fur JM (February 1975). "Pharmacokinetic study of maleate acid of 2-(N,N-dimethylaminoethanol-14C1)-cyclohexylpropionate (cyprodenate) and of N,N-dimethylaminoethanol-14C1 in animals". Arzneimittel-Forschung. 25 (2): 201–7. PMID 1173033.
  2. ^ Bobkov I, Morozov IS (October 1982). "[Correction of psychodepressive effects of benzodiazepine tranquilizers by administration of psychostimulants]". Biulleten' Eksperimental'noi Biologii I Meditsiny. 94 (10): 48–51. doi:10.1007/BF00827201. PMID 6129008. S2CID 19153614.


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