Ceramidase: Difference between revisions
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'''Ceramidase''' ({{EC number|3.5.1.23}}, ''acylsphingosine deacylase'', ''glycosphingolipid ceramide deacylase'') is an enzyme which cleaves fatty acids from [[ceramide]], producing [[sphingosine]] (SPH) which in turn is [[phosphorylated]] by a [[sphingosine kinase]] to form [[sphingosine-1-phosphate]] (S1P).<ref name="pmid18619555">{{cite journal | author = Mao C, Obeid LM | title = Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate | journal = Biochim. Biophys. Acta | volume = 1781 | issue = 9 | pages = 424–34 |date=September 2008 | pmid = 18619555 | doi = 10.1016/j.bbalip.2008.06.002 | url = | pmc = 2614331 }}</ref> |
'''Ceramidase''' ({{EC number|3.5.1.23}}, ''acylsphingosine deacylase'', i love bae ''glycosphingolipid ceramide deacylase'') is an enzyme which cleaves fatty acids from [[ceramide]], producing [[sphingosine]] (SPH) which in turn is [[phosphorylated]] by a [[sphingosine kinase]] to form [[sphingosine-1-phosphate]] (S1P).<ref name="pmid18619555">{{cite journal | author = Mao C, Obeid LM | title = Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate | journal = Biochim. Biophys. Acta | volume = 1781 | issue = 9 | pages = 424–34 |date=September 2008 | pmid = 18619555 | doi = 10.1016/j.bbalip.2008.06.002 | url = | pmc = 2614331 }}</ref> |
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== Function == |
== Function == |
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Revision as of 03:47, 5 December 2014
Ceramidase (EC 3.5.1.23, acylsphingosine deacylase, i love bae glycosphingolipid ceramide deacylase) is an enzyme which cleaves fatty acids from ceramide, producing sphingosine (SPH) which in turn is phosphorylated by a sphingosine kinase to form sphingosine-1-phosphate (S1P).[1]
Function
Ceramide, SPH, and S1P are bioactive lipids that mediate cell proliferation, differentiation, apoptosis, adhesion, and migration. Presently, 7 human ceramidases encoded by 7 distinct genes have been cloned:[1]
- acid ceramidase (ASAH1) – cell survival
- neutral ceramidase (ASAH2, ASAH2B, ASAH2C) – protective against inflammatory cytokines
- alkaline ceramidase 1 (ACER1) – mediating cell differentiation by controlling the generation of SPH and S1P
- alkaline ceramidase 2 (ACER2) – important for cell proliferation and survival
- alkaline ceramidase 3 (ACER3)
Clinical significance
A deficiency in ASAH1 is associated with Farber disease.
References
- ^ a b Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555.
External links
- Ceramidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.5.1.23
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