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{{PBB|geneid=7753}}
{{PBB|geneid=7753}}
'''Zinc finger protein 202''' is a [[transcription factor]] first associated with [[breast cancer]]. It is a [[protein]] that, in humans, is encoded by the ''ZNF202'' [[gene]].<ref name="pmid9790754">{{vcite2 journal | vauthors = Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M | title = Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins | journal = Genomics | volume = 52 | issue = 3 | pages = 358–62 | date = Sep 1998 | pmid = 9790754 | pmc = | doi = 10.1006/geno.1998.5419 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZNF202 zinc finger protein 202| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7753| accessdate = }}</ref>
'''Zinc finger protein 202''' is a [[transcription factor]] first associated with [[breast cancer]]. It is a [[protein]] that, in humans, is encoded by the ''ZNF202'' [[gene]].<ref name="pmid9790754">{{cite journal | vauthors = Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M | title = Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins | journal = Genomics | volume = 52 | issue = 3 | pages = 358–62 | date = Sep 1998 | pmid = 9790754 | pmc = | doi = 10.1006/geno.1998.5419 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZNF202 zinc finger protein 202| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7753| accessdate = }}</ref>


== Clinical significance ==
== Clinical significance ==
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{{refbegin | 2}}
{{refbegin | 2}}
* {{cite book | title=Zinc finger proteins: from atomic contact to cellular function | series=Molecular biology intelligence unit | first1=Shiro | last1=Iuchi | first2=Natalie | last2=Kuldell | publisher=シュプリンガー・ジャパン株式会社かぶしきがいしゃ | year=2005 | isbn=0-306-48229-0 | page=161 }}
* {{cite book | title=Zinc finger proteins: from atomic contact to cellular function | series=Molecular biology intelligence unit | first1=Shiro | last1=Iuchi | first2=Natalie | last2=Kuldell | publisher=シュプリンガー・ジャパン株式会社かぶしきがいしゃ | year=2005 | isbn=0-306-48229-0 | page=161 }}
* {{vcite2 journal | vauthors = Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ | title = Antigens recognized by autologous antibody in patients with renal-cell carcinoma | journal = International Journal of Cancer. Journal International Du Cancer | volume = 83 | issue = 4 | pages = 456–64 | date = Nov 1999 | pmid = 10508479 | doi = 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 }}
* {{cite journal | vauthors = Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ | title = Antigens recognized by autologous antibody in patients with renal-cell carcinoma | journal = International Journal of Cancer. Journal International Du Cancer | volume = 83 | issue = 4 | pages = 456–64 | date = Nov 1999 | pmid = 10508479 | doi = 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 }}
* {{vcite2 journal | vauthors = Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S | title = The SCAN domain mediates selective oligomerization | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 17173–9 | date = Jun 2000 | pmid = 10747874 | doi = 10.1074/jbc.M000119200 }}
* {{cite journal | vauthors = Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S | title = The SCAN domain mediates selective oligomerization | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 17173–9 | date = Jun 2000 | pmid = 10747874 | doi = 10.1074/jbc.M000119200 }}
* {{vcite2 journal | vauthors = Wagner S, Hess MA, Ormonde-Hanson P, Malandro J, Hu H, Chen M, Kehrer R, Frodsham M, Schumacher C, Beluch M, Honer C, Skolnick M, Ballinger D, Bowen BR | title = A broad role for the zinc finger protein ZNF202 in human lipid metabolism | journal = The Journal of Biological Chemistry | volume = 275 | issue = 21 | pages = 15685–90 | date = May 2000 | pmid = 10748193 | doi = 10.1074/jbc.M910152199 }}
* {{cite journal | vauthors = Wagner S, Hess MA, Ormonde-Hanson P, Malandro J, Hu H, Chen M, Kehrer R, Frodsham M, Schumacher C, Beluch M, Honer C, Skolnick M, Ballinger D, Bowen BR | title = A broad role for the zinc finger protein ZNF202 in human lipid metabolism | journal = The Journal of Biological Chemistry | volume = 275 | issue = 21 | pages = 15685–90 | date = May 2000 | pmid = 10748193 | doi = 10.1074/jbc.M910152199 }}
* {{vcite2 journal | vauthors = Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G | title = The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux | journal = The Journal of Biological Chemistry | volume = 276 | issue = 15 | pages = 12427–33 | date = Apr 2001 | pmid = 11279031 | doi = 10.1074/jbc.M100218200 }}
* {{cite journal | vauthors = Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G | title = The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux | journal = The Journal of Biological Chemistry | volume = 276 | issue = 15 | pages = 12427–33 | date = Apr 2001 | pmid = 11279031 | doi = 10.1074/jbc.M100218200 }}
* {{vcite2 journal | vauthors = Babb R, Bowen BR | title = SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain | journal = The Biochemical Journal | volume = 370 | issue = Pt 2 | pages = 719–27 | date = Mar 2003 | pmid = 12444922 | pmc = 1223195 | doi = 10.1042/BJ20021378 }}
* {{cite journal | vauthors = Babb R, Bowen BR | title = SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain | journal = The Biochemical Journal | volume = 370 | issue = Pt 2 | pages = 719–27 | date = Mar 2003 | pmid = 12444922 | pmc = 1223195 | doi = 10.1042/BJ20021378 }}
* {{vcite2 journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{vcite2 journal | vauthors = Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A | title = Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study | journal = Atherosclerosis | volume = 188 | issue = 1 | pages = 43–50 | date = Sep 2006 | pmid = 16289551 | doi = 10.1016/j.atherosclerosis.2005.10.014 }}
* {{cite journal | vauthors = Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A | title = Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study | journal = Atherosclerosis | volume = 188 | issue = 1 | pages = 43–50 | date = Sep 2006 | pmid = 16289551 | doi = 10.1016/j.atherosclerosis.2005.10.014 }}
* {{vcite2 journal | vauthors = Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A | title = Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population | journal = Journal of Lipid Research | volume = 47 | issue = 5 | pages = 944–52 | date = May 2006 | pmid = 16467280 | doi = 10.1194/jlr.M500521-JLR200 }}
* {{cite journal | vauthors = Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A | title = Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population | journal = Journal of Lipid Research | volume = 47 | issue = 5 | pages = 944–52 | date = May 2006 | pmid = 16467280 | doi = 10.1194/jlr.M500521-JLR200 }}
{{refend}}
{{refend}}


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* {{MeshName|ZNF202+protein,+human}}
* {{MeshName|ZNF202+protein,+human}}


⚫
{{gene-11-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors|g2}}
{{Transcription factors|g2}}

[[Category:Transcription factors]]
[[Category:Transcription factors]]
[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Proteins]]
[[Category:Proteins]]


⚫
{{gene-11-stub}}

Revision as of 10:13, 2 August 2015

Template:PBB Zinc finger protein 202 is a transcription factor first associated with breast cancer. It is a protein that, in humans, is encoded by the ZNF202 gene.[1][2]

Clinical significance

Variants of this protein have been discovered to be strongly associated with coronary heart disease and atherosclerosis.

References

  1. ^ Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M (Sep 1998). "Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins". Genomics. 52 (3): 358–62. doi:10.1006/geno.1998.5419. PMID 9790754.
  2. ^ "Entrez Gene: ZNF202 zinc finger protein 202".

Further reading

  • Iuchi, Shiro; Kuldell, Natalie (2005). Zinc finger proteins: from atomic contact to cellular function. Molecular biology intelligence unit. シュプリンガー・ジャパン株式会社かぶしきがいしゃ. p. 161. ISBN 0-306-48229-0.
  • Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. Journal International Du Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
  • Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry. 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Wagner S, Hess MA, Ormonde-Hanson P, Malandro J, Hu H, Chen M, Kehrer R, Frodsham M, Schumacher C, Beluch M, Honer C, Skolnick M, Ballinger D, Bowen BR (May 2000). "A broad role for the zinc finger protein ZNF202 in human lipid metabolism". The Journal of Biological Chemistry. 275 (21): 15685–90. doi:10.1074/jbc.M910152199. PMID 10748193.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G (Apr 2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". The Journal of Biological Chemistry. 276 (15): 12427–33. doi:10.1074/jbc.M100218200. PMID 11279031.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  • Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal. 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A (Sep 2006). "Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study". Atherosclerosis. 188 (1): 43–50. doi:10.1016/j.atherosclerosis.2005.10.014. PMID 16289551.
  • Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A (May 2006). "Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population". Journal of Lipid Research. 47 (5): 944–52. doi:10.1194/jlr.M500521-JLR200. PMID 16467280.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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