Off-label use: Difference between revisions
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===United Kingdom=== |
===United Kingdom=== |
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Physicians in the United Kingdom can prescribe medications off-label. According to the British General Medical Council, off-label prescriptions must better serve patient needs than alternatives and must be supported by evidence or experience to demonstrate safety and efficacy.<ref>{{cite web|url=http://www.gmc-uk.org/guidance/current/library/prescriptions_faqs.asp#5d |title=GMC | Good practice in prescribing medicines - guidance for doctors |publisher=Gmc-uk.org |date=2007-02-16 |accessdate=2011-11-21}}</ref> |
Physicians in the United Kingdom can prescribe medications off-label. According to the British General Medical Council, off-label prescriptions must better serve patient needs than alternatives and must be supported by evidence or experience to demonstrate safety and efficacy.<ref>{{cite web|url=http://www.gmc-uk.org/guidance/current/library/prescriptions_faqs.asp#5d |title=GMC | Good practice in prescribing medicines - guidance for doctors |publisher=Gmc-uk.org |date=2007-02-16 |accessdate=2011-11-21 |deadurl=yes |archiveurl=https://web.archive.org/web/20081219225153/http://www.gmc-uk.org:80/guidance/current/library/prescriptions_faqs.asp |archivedate=2008-12-19 |df= }}</ref> |
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==Examples== |
==Examples== |
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== External links == |
== External links == |
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* [http://www.thedoctorwillseeyounow.com/articles/bioethics/offlabel_11/ Article about the Bioethics of off-label prescribing.] |
* [https://web.archive.org/web/20080521180039/http://www.thedoctorwillseeyounow.com:80/articles/bioethics/offlabel_11/ Article about the Bioethics of off-label prescribing.] |
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* [http://psychcentral.com/blog/archives/2008/02/17/fda-to-drug-companies-off-label-use-ok/ Recent FDA proposal to loosen off-label marketing restrictions.] |
* [http://psychcentral.com/blog/archives/2008/02/17/fda-to-drug-companies-off-label-use-ok/ Recent FDA proposal to loosen off-label marketing restrictions.] |
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Revision as of 14:01, 12 November 2016
Regulation of therapeutic goods in the United States |
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Prescription drugs Over-the-counter drugs |
Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration.[1] Both prescription drugs and over-the-counter drugs (OTCs) can be used in off-label ways, although most studies of off-label use focus on prescription drugs.
Off-label use is generally legal unless it violates ethical guidelines or safety regulations. The ability to prescribe drugs for uses beyond the officially approved indications is commonly used to good effect by healthcare providers. For example, methotrexate is commonly used off-label because its immunomodulatory effects relieve various disorders.[2] However, off-label use can entail health risks and differences in legal liability. Marketing of pharmaceuticals for off-label use is usually prohibited.
Indications and labeling laws
An indication is when a drug is medically appropriate for a given condition; an approved indication is when a government drug regulatory agency formally agrees that the drug is medically appropriate for the named condition. Indications may depend not only upon the medical condition that is being treated, but also upon other factors, such as dose, the patient's age, size and sex, whether the patient is pregnant or breastfeeding, and other medical conditions. For example, aspirin is generally indicated for a headache, but it is not indicated for headaches in people with an allergic reaction to it.
When the drug's manufacturer has received a marketing approval from the government agency, then it is allowed to promote the drug for the specific, agreed-upon approved indications in that country. All legally approved indications are listed on the drug package insert or "label". Drug manufacturers are not legally permitted to encourage the use of regulated drugs for any indications that have not been formally approved by the country's government, even if significant scientific evidence exists for that unapproved indication, or even if another country's drug agency has approved that indication.
However, healthcare providers are not required to limit prescriptions or recommendations to the indications approved by their country's drug regulatory agency. Prescribing a drug for a condition or use that has not been formally approved by the country's drug regulatory agency is called off-label use.
Frequency of off-label use
Off-label use is very common. Generic drugs generally have no sponsor as their indications and use expands, and incentives are limited to initiate new clinical trials to generate additional data for approval agencies to expand indications of proprietary drugs.[1] Up to one-fifth of all drugs are prescribed off-label and amongst psychiatric drugs, off-label use rises to 31%.[3]
Among use of antipsychotic medications in the United States, a shift occurred from typical agents in 1995 (84% of all antipsychotic visits) to atypical agents by 2008 (93%). Atypical use has grown far beyond substitution for the now infrequently used typical agents.[4]
A 2009 study found that 62% of U.S. pediatric office visits from 2001-2004 included off-label prescribing, with younger children having a higher chance of receiving off-label prescriptions. Specialist physicians also prescribed off-label more frequently than general pediatricians.[5] In 2003, passage of the Pediatric Research Equity Act gave the FDA power to require pharmaceutical companies to perform clinical trials in all age groups in which clinical use is reasonably foreseeable. By some estimates, the number of clinical trials performed in children from 2002 - 2012 exceeded that in the prior 50 years.[6]
In 2014, the American Academy of Pediatrics released a statement regarding off-label use of pharmaceuticals in children. The article recommends to pediatricians that "Off-label use is neither incorrect nor investigational if based on sound scientific evidence, expert medical judgment, or published literature" and that " Evidence, not label indication, remains the gold standard from which practitioners should draw when making therapeutic decisions for their patients." The statement further advocates additional support and additional incentives for clinical testing of drugs in children, and publication of all results irrespective of positive outcome.[7]
A study published in 2006 found that off-label use was the most common in anticonvulsants. This study also found that 73% of off-label use had little or no scientific support.[3]
By default use of non-approved drugs is common in obstetrics as, by 2010, during almost five decades of activity the Food and Drug Administration (FDA) had approved only two drugs for obstetrical indications, namely oxytocin and dinoprostone.[8] A small market and the high risk of medicolegal action, as exemplified by the Bendectin case, may explain the reluctance to develop drugs for approval.[8]
Some drugs are used more frequently off-label than for their original, approved indications. A 1991 study by the U.S. General Accounting Office found that one-third of all drug administrations to cancer patients were off-label, and more than half of cancer patients received at least one drug for an off-label indication. A 1997 survey of 200 cancer physicians by the American Enterprise Institute and the American Cancer Society found that 60% of them prescribed drugs off-label.[9][10] In some cases, patients may perceive the efficacy of treatments for off-label purposes to be higher than for their indicated purpose.[11] Frequently, the standard of care for a particular type or stage of cancer involves the off-label use of one or more drugs. An example is the use of tricyclic antidepressants to treat neuropathic pain. This old class of antidepressants is now rarely used for clinical depression due to side effects, but the tricyclics are often effective for treating pain (e.g. neuropathy),[12] as well as attention deficit/hyperactivity disorder(ADHD) particularly in adults.[13][14][15]
Regulations of off-label use in various countries
United States
In the United States, no law prohibits a physician or other healthcare practitioner from prescribing an approved medication for other uses than their specific FDA-approved indications.[citation needed] Pharmaceutical companies are not allowed to promote a drug for any other purpose without formal FDA approval. Marketing information for the drug will list one or more indications, that is, illnesses or medical conditions for which the drug has been shown to be both safe and effective.
However, once a drug has been approved for sale for one purpose, physicians are free to prescribe it for any other purpose that in their professional judgment is both safe and effective, and are not limited to official, FDA-approved indications. This off-label prescribing is most commonly done with older, generic medications that have found new uses but have not had the formal (and often costly) applications and studies required by the FDA to formally approve the drug for these new indications. However, there is often extensive medical literature to support the off-label use.
A leading example of how regulatory agencies approach off-label use is provided by the United States Food and Drug Administration (FDA)'s Center for Drug Evaluation and Research, which reviews a company's New Drug Application (NDA) for clinical trial data to see if the results support the drug for a specific use or indication.[16] If satisfied that the drug is safe and effective, the drug's manufacturer and the FDA agree on specific language describing dosage, route of administration, and other information to be included on the drug's label. More detail is included in the drug's package insert.
The FDA approves a drug for prescription use, and continues to regulate the pharmaceutical industry's promotional practices for that drug through the work of the Office of Prescription Drug Promotion (OPDP, formerly the Division for Drug Marketing, Advertisement and Communication (DDMAC).[17] The FDA does not have the legal authority to regulate the practice of the medicine, and the physician may prescribe a drug off-label. Contrary to popular notion, it is legal in the United States and in many other countries to use drugs off-label, including controlled substances such as opiates. Actiq, for example, is commonly prescribed off-label even though it is a Schedule II controlled substance. While it would be legal for a physician to independently decide to prescribe a drug such as Actiq off-label, it is illegal for the company to promote off-label uses to prescribers. In fact, Cephalon, the maker of Actiq, was fined for illegal promotion of the drug in September 2008.[18] Under the Food, Drug, and Cosmetic Act (FDCA) at U.S.C. 21 §§301-97, manufacturers are prohibited from directly marketing a drug for a use other than the FDA-approved indication. However, in December 2012, the United States Second Circuit Court found that promotion of off-label uses by a company sales representative was considered to be protected speech per the First Amendment.[19] In addition, The Food and Drug Administration Modernization Act of 1997 created an exception to the prohibition of off-label marketing, allowing manufacturers to provide medical practitioners with publications on off-label uses of a drug, in response to an unsolicited request.[20] In 2004, the federal government and whistleblower David Franklin reached a $430 million settlement in Franklin v. Parke-Davis to resolve claims that Warner-Lambert engaged in off-label promotion of Neurontin in violation of the FDCA and the False Claims Act. At the time, the settlement was one of the largest recoveries against a pharmaceutical company in U.S. history, and the first off-label promotion settlement in U.S. history.[21]
United Kingdom
Physicians in the United Kingdom can prescribe medications off-label. According to the British General Medical Council, off-label prescriptions must better serve patient needs than alternatives and must be supported by evidence or experience to demonstrate safety and efficacy.[22]
Examples
- Actiq (oral transmucosal fentanyl citrate), a controlled substance, is used off-label to treat moderate to severe chronic, non-malignant pain even though it is approved in the United States solely for breakthrough pain in cancer patients.[23]
- Bevacizumab (Avastin) has been used against wet age-related macular degeneration, as well as macular edema from diseases such as diabetic retinopathy and central retinal vein occlusion.[24]
- Buprenorphine has been shown experimentally (1982–1995) to be effective against severe, refractory depression.[25][26]
- Bupropion, when sold under the brand name Wellbutrin is indicated for depression. It is also sold as a smoking cessation drug, under the name Zyban. In Ontario, Canada, smoking cessation drugs are not covered by provincial drug plans. Thus, a physician can write a prescription for Wellbutrin to assist with giving up the habit of smoking. Sometimes it is also prescribed as second-line treatment of ADHD, often in combination with the stimulant being used, but it was also shown to work on its own as a norepinephrine–dopamine reuptake inhibitor.[27] It is also given to counter SSRIs' negative effects on the libido, anorgasmia and anhedonia.
- Carbamazepine, or Tegretol, has been used as a mood stabilizer and is accepted treatment for bipolar disorder.[28]
- Dexamethasone and Betamethasone in premature labor, to enhance pulmonary maturation of the fetus.[8]
- Doxepin has been used to treat Angiodema and severe allergic reactions due to its strong antihistamine properties.[29]
- Gabapentin, approved for treatment of seizures and postherpetic neuralgia in adults, is used off-label for a variety of conditions including bipolar disorder, essential tremor, hot flashes, migraine prophylaxis, neuropathic pain syndromes, phantom limb syndrome, and restless leg syndrome.[30]
- Magnesium sulfate is used in obstetrics for premature labor and preeclampsia.[8]
- Methotrexate (MTX), approved for the treatment of choriocarcinoma, is frequently used for the medical treatment of an unruptured ectopic pregnancy.[31] There is no FDA-approved drug for this purpose and there is little incentive to sponsor an unpatented drug such as MTX for FDA-approval.
- Misoprostol is approved for medical abortion regimens when administered at the office, but clinicians often give abortion patients the drug to be taken at home.[32]
- Retigabine (INN) is an anticonvulsant used as an adjunctive treatment for partial epilepsies in treatment-experienced adult patients. Currently, it is being tested in the treatment of Tinnitus.
- The SSRI medication sertraline (Zoloft) is approved as an anti-depressant but is also commonly prescribed off-label to help men suffering from premature ejaculation.[33]
- Low-dose naltrexone is cheap without side effects and used to cancer and autoimmune diseases like Focal segmental glomerulosclerosis.
- Tramadol, an opioid painkiller, is used to treat ejaculatio praecox,[34][35] and may also be applied against restless legs syndrome.[citation needed]
Veterinary medicines
The veterinarian has a much smaller pharmacopeia available than does the human practitioner. Therefore, drugs are more likely to be used "off-label" – typically, this involves the use of a human medication in an animal, where there is no corresponding medication licensed for that species. This problem is compounded in "exotic" species (such as reptiles and rodents) where there are very few, if any licensed medications. In addition, especially in Europe, equine veterinarians are forced to use many drugs off-label, as the horse is classified as a "food-producing animal" and many veterinary drugs are labeled specifically not for use in animals intended for human consumption.
This practice is permitted by the Animal Medicinal Drug Use Clarification Act of 1994 (P.L. 103-396). FDA specifically prohibits extralabel use of a number of antibiotics, anti-inflammatory drugs and hormones in food producing animals. FDA also tightly controls the use of certain veterinary-prescribed drugs when administered in the feed of food-producing animals.[36]
Research relating to off-label use
According to a national random mail survey of 599 primary care physicians and 600 psychiatrists in the United States, there is a strong indication between a physician’s belief that a use is approved and the known evidence supporting that use, although almost half of physicians believed one off-label use that had little or no supporting evidence. This shows that there is a need for informing physicians about the evidence supporting off-label prescriptions, although the FDA only regulates drug marketing not drug prescribing.[37]
- Alexander GC. Clinical prescribing (and off-label use) in a second-best world. Medical care. 2010;48:285-287. (Invited editorial) [38]
- Tabarrok A. Assessing the FDA via the anomaly of off-label drug prescribing. Independent Review. 2000. V;1:25-53.
- Walton SM, Schumock GT, Lee KV, Alexander GC, Melzter DO, Stafford RS (2008). "Prioritizing medications for policy and research initiatives examining off-label prescribing". Pharmocotherapy. 28: 1443–1452.
- Harold J. DeMonaco; Ayfer Ali; Eric Von Hippel (2006). "The Major Role of Clinicians in the Discovery of Off-Label Drug Therapies" (PDF). Pharmacotherapy. 26 (3): 323–332. doi:10.1592/phco.26.3.323.
- Chen DT, Wynia MK, Moloney RM, Alexander GC (2009). "Physician knowledge of the FDA-approved indications of commonly prescribed drugs: results of a national survey". Pharmacoepidemiology and Drug Safety. 18 (11): 1–7. doi:10.1002/pds.1825. PMID 19697444.
Controversies
Marketing of off-label use
In 1993, the FDA approved gabapentin, marketed by Pfizer under the name "Neurontin", only for treatment of seizures. Pfizer subsidiary Warner-Lambert illegally used scientific activities, including continuing medical education and research, to commercially promote gabapentin, so that within five years the drug was being widely used for the off-label treatment of pain and psychiatric conditions—conditions that had not been approved by FDA. In 2004, Warner-Lambert admitted to charges that it violated FDA regulations by promoting the drug for these off-label uses: pain, psychiatric conditions, migraine, and other unapproved uses.[39] The company paid $430 million to the federal government to settle the case.[40]
Access to pharmaceutical industry documents has revealed marketing strategies used to promote drugs for off-label use.[41] The United States federal government is aggressively pursuing criminal and civil cases against pharmaceutical companies and their employees for promoting off-label uses of prescription drugs.[42] Between 2003 and 2008, U.S. federal prosecutors and state attorneys general brought more than a dozen cases against drug manufacturers for off-label marketing and won more than $6 billion in criminal and civil settlements.[43] In September 2009, Pfizer paid $1.3 billion, the largest criminal fine ever imposed in the United States, for the off-label marketing of Bextra and three other drugs. Pfizer paid an additional $1 billion in civil penalties resulting from the same illegal activities.[44]
First Amendment issues
The FDA takes the position that a drug manufacturer may not promote its drug for an unapproved use, and that any such promotion is false and misleading simply because it is not FDA-approved. However, many off-label uses are in fact effective and safe, as is evidenced by subsequent FDA approval of such uses for numerous drug products. The Supreme Court has in recent years begun to address the boundaries between government regulation of pharmaceuticals and the First Amendment free speech guarantee. Some legal observers have suggested that the trend in the Court's decisions may ultimately reduce the ability of FDA to prevent broader dissemination of off-label information about approved drug products.[45]
A three-judge panel of the United States Court of Appeals for the Second Circuit in Manhattan ruled on December 5, 2012 that a drug sales representative who was criminally prosecuted for making off-label promotional statements about Xyrem had suffered a violation of his First Amendment right to freedom of speech.[46]
See also
References
- ^ a b Randall S. Stafford. "Regulating Off-Label Drug Use — Rethinking the Role of the FDA". N Engl J Med. 358 (14): 1427–1429. doi:10.1056/NEJMp0802107.
- ^ Briem, S; et al. (2011), "[Current "off label use" of methotrexate for chronic inflammatory rheumatic diseases]", Z Rheumatol, 70 (2): 123–128, doi:10.1007/s00393-010-0685-2, PMID 21267732.
- ^ a b David C. Radley; Stan N. Finkelstein; Randall S. Stafford (2006). "Off-label Prescribing Among Office-Based Physicians". Archives of Internal Medicine. 166 (9): 1021–1026. doi:10.1001/archinte.166.9.1021. PMID 16682577.
- ^ Alexander GC; Gallagher SA; Mascola A (2011). "Increasing off-label use of antipsychotic medications". Pharmacoepidemiology and Drug Safety. 20 (2): 177–184. doi:10.1002/pds.2082. PMC 3069498. PMID 21254289.
- ^ Alicia Bazzano MD MPH; Rita Mangione-Smith MD; Matthias Schonlau; Marika Suttorp MS; Robert Brook MD ScD (2009). "Off-label prescribing to children in the United States outpatient setting". Ambulatory Pediatrics. 9 (2): 81–8. doi:10.1016/j.acap.2008.11.010. PMID 19329098.
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: CS1 maint: multiple names: authors list (link) - ^ Christensen ML (2012). "Best pharmaceuticals for children act and pediatric research equity act: time for permanent status". J Pediatr Pharmacol Ther. 17 (2): 140–1. doi:10.5863/1551-6776-17.2.140. PMC 3470432. PMID 23185144.
- ^ Frattarelli DA, Galinkin JL, Green TP, Johnson TD, Neville KA, Paul IM, Van Den Anker JN (2014). "Off-label use of drugs in children". Pediatrics. 133 (3): 563–7. doi:10.1542/peds.2013-4060. PMID 24567009.
- ^ a b c d Wing DA, Powers B, Hickok D (April 2010). "U.S. Food and Drug Administration Drug Approval: Slow Advances in Obstetric Care in the United States". Obstetrics & Gynecology. 115 (4): 825–33. doi:10.1097/AOG.0b013e3181d53843. PMID 20308845.
{{cite journal}}
: CS1 maint: year (link) - ^ Day to Day (2008-10-22). "Prozac Isn't The Same In A Kid's Body". NPR. Retrieved 2011-11-21.
- ^ "Why is off-label use of drugs so common in cancer treatment?". National Cancer Institute. Retrieved 2009-07-12.
- ^ Jeana Frost; Sally Okun; Timothy Vaughan; James Heywood; Paul Wicks (2011). "Patient-reported Outcomes as a Source of Evidence in Off-Label Prescribing: Analysis of Data From PatientsLikeMe". Journal of Medical Internet Research. 13 (1): e6. doi:10.2196/jmir.1643. PMC 3221356. PMID 21252034.
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: CS1 maint: unflagged free DOI (link) - ^ Sindrup SH; et al. "Antidepressants in the treatment of neuropathic pain". nih.gov.
- ^ "Medscape: Medscape Access". medscape.com.
- ^ "Treatment Options for ADHD / ADD in Children and Teens". WebMD.
- ^ "Nonstimulant Therapy (Strattera) and Other ADHD Drugs - MedicineNet". MedicineNet.
- ^ "Development & Approval Process (Drugs)". Fda.gov. 2009-10-27. Retrieved 2011-11-21.
- ^ "The Office of Prescription Drug Promotion (OPDP)". Fda.gov. 2008-03-25. Retrieved 2011-11-21.
- ^ [1][dead link]
- ^ "Off-Label Use Promotion is Protected Free Speech". blogs.findlaw.com. 2012-12-04. Retrieved 2014-06-26.
- ^ 21 U.S.C. §360aaa-6
- ^ "#322: 05-13-04 WARNER-LAMBERT TO PAY $430 MILLION TO RESOLVE CRIMINAL & CIVIL HEALTH CARE LIABILITY RELATING TO OFF-LABEL PROMOTION". Justice.gov. 2004-05-13. Retrieved 2013-04-30.
- ^ "GMC | Good practice in prescribing medicines - guidance for doctors". Gmc-uk.org. 2007-02-16. Archived from the original on 2008-12-19. Retrieved 2011-11-21.
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- ^ Bodkin JA, et al. (1995). "Buprenorphine Treatment of Refractory Depression". Journal of Clinical Psychopharmacology. 15 (1): 49–57. doi:10.1097/00004714-199502000-00008. PMID 7714228.
- ^ Maneeton, Narong; Maneeton, Benchalak; Srisurapanont, Manit; Martin, Stephen D. (2011-12-01). "Bupropion for adults with attention-deficit hyperactivity disorder: meta-analysis of randomized, placebo-controlled trials". Psychiatry and Clinical Neurosciences. 65 (7): 611–617. doi:10.1111/j.1440-1819.2011.02264.x. ISSN 1440-1819. PMID 22176279.
- ^ "Mood Stabilizers for Bipolar Disorder (Manic Depressive)". Leeheymd.com. 2003-08-01. Retrieved 2011-11-21.
- ^ "PsychiatryOnline | American Journal of Psychiatry | Doxepin as a potent H2 and H2 antihistamine for epigastric distress". Ajp.psychiatryonline.org. Retrieved 2011-11-21.
- ^ http://idahodur.isu.edu/leaflets/2004/GABAPENTIN%20EDU%20LEAFLET%202004.pdf
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- ^ "Medscape: Medscape Access". Emedicine.com. Retrieved 2011-11-21.
- ^ Safarinejad, Mohammad Reza MD; Hosseini, Seyyed Yoosof MD: Safety and Efficacy of Tramadol in the Treatment of Premature Ejaculation: A Double-blind, Placebo-Controlled, Fixed-Dose, Randomized Study. In: Journal of Clinical Psychopharmacology, 2006, 26:27–31.
- ^ Salem, E. A., Wilson, S. K., Bissada, N. K., Delk, J. R., Hellstrom, W. J. and Cleves, M. A. (2008), Tramadol HCL has Promise in On-Demand Use to Treat Premature Ejaculation. In: The Journal of Sexual Medicine, 5: 188–193, doi:10.1111/j.1743-6109.2006.00424.x.
- ^ CRS Report for Congress: Agriculture: A Glossary of Terms, Programs, and Laws, 2005 Edition - Order Code 97-905
- ^ Chen DT, Wynia MK, Moloney RM, Alexander GC. U.S. Physician knowledge of the FDA-approved indications of commonly prescribed drugs: results of a national survey. Pharmacoepidemiology and Drug Safety. 2009;18:1-7 [3]
- ^ "Clinical Prescribing (and Off-Label Use) in a Second-Best Wo... : Medical Care". Journals.lww.com. doi:10.1097/MLR.0b013e3181d60408. Retrieved 2011-11-21.
- ^ Jane E. Henney, MD (15 August 2006). "Editorial: safeguarding patient welfare: who's in charge?". Annals of Internal Medicine. 145 (4): 305–307. doi:10.7326/0003-4819-145-4-200608150-00013. PMID 16908923. Retrieved 2006-08-14.
- ^ US Department of Justice Press Release: Warner-Lambert to Pay $430 Million to Resolve Criminal & Civil Health Care Liability Relating to Off-Label Promotion, retrieved 14 August 2006
- ^ Michael A. Steinman, MD; Lisa A. Bero; Mary-Margaret Chren, MD; C. Seth Landefeld, MD (15 August 2006). "Narrative review: the promotion of gabapentin: an analysis of internal industry documents" (abstract). Annals of Internal Medicine. 145 (4): 284–293. doi:10.7326/0003-4819-145-4-200608150-00008. PMID 16908919. Retrieved 2006-08-14.
{{cite journal}}
: Unknown parameter|last-author-amp=
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- ^ Chris Adams (February 1, 2009). "Late move on drugs by Bush FDA could be dangerous". McClatchy Newspapers.
- ^ [4] Template:Wayback
- ^ "Government Regulation of Commercial Speech After Sorrell v. IMS Health, Inc" (PDF). www.wileyrein.com. Retrieved 2012-12-12.
- ^ "Off-Label Drug Marketing Is 'Free Speech,' Court Rules". ABC News. Retrieved 10 December 2012.