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{{Infobox_gene}} |
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'''Zinc finger protein 202''' is a [[transcription factor]] first associated with [[breast cancer]]. It is a [[protein]] that, in humans, is encoded by the ''ZNF202'' [[gene]].<ref name="pmid9790754">{{cite journal | vauthors = Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M | title = Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins | journal = Genomics | volume = 52 | issue = 3 | pages = 358–62 | date = Sep 1998 | pmid = 9790754 |
'''Zinc finger protein 202''' is a [[transcription factor]] first associated with [[breast cancer]]. It is a [[protein]] that, in humans, is encoded by the ''ZNF202'' [[gene]].<ref name="pmid9790754">{{cite journal | vauthors = Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M | title = Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins | journal = Genomics | volume = 52 | issue = 3 | pages = 358–62 | date = Sep 1998 | pmid = 9790754 | doi = 10.1006/geno.1998.5419 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZNF202 zinc finger protein 202| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7753}}</ref> |
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== Clinical significance == |
== Clinical significance == |
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* {{cite journal | vauthors = Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G | title = The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux | journal = The Journal of Biological Chemistry | volume = 276 | issue = 15 | pages = 12427–33 | date = Apr 2001 | pmid = 11279031 | doi = 10.1074/jbc.M100218200 | doi-access = free }} |
* {{cite journal | vauthors = Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G | title = The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux | journal = The Journal of Biological Chemistry | volume = 276 | issue = 15 | pages = 12427–33 | date = Apr 2001 | pmid = 11279031 | doi = 10.1074/jbc.M100218200 | doi-access = free }} |
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* {{cite journal | vauthors = Babb R, Bowen BR | title = SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain | journal = The Biochemical Journal | volume = 370 | issue = Pt 2 | pages = 719–27 | date = Mar 2003 | pmid = 12444922 | pmc = 1223195 | doi = 10.1042/BJ20021378 }} |
* {{cite journal | vauthors = Babb R, Bowen BR | title = SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain | journal = The Biochemical Journal | volume = 370 | issue = Pt 2 | pages = 719–27 | date = Mar 2003 | pmid = 12444922 | pmc = 1223195 | doi = 10.1042/BJ20021378 }} |
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* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network| |
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network|author-link30=Huda Zoghbi | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R| s2cid = 4427026}} |
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* {{cite journal | vauthors = Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A | title = Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study | journal = Atherosclerosis | volume = 188 | issue = 1 | pages = 43–50 | date = Sep 2006 | pmid = 16289551 | doi = 10.1016/j.atherosclerosis.2005.10.014 }} |
* {{cite journal | vauthors = Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A | title = Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study | journal = Atherosclerosis | volume = 188 | issue = 1 | pages = 43–50 | date = Sep 2006 | pmid = 16289551 | doi = 10.1016/j.atherosclerosis.2005.10.014 }} |
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* {{cite journal | vauthors = Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A | title = Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population | journal = Journal of Lipid Research | volume = 47 | issue = 5 | pages = 944–52 | date = May 2006 | pmid = 16467280 | doi = 10.1194/jlr.M500521-JLR200 | doi-access = free }} |
* {{cite journal | vauthors = Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A | title = Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population | journal = Journal of Lipid Research | volume = 47 | issue = 5 | pages = 944–52 | date = May 2006 | pmid = 16467280 | doi = 10.1194/jlr.M500521-JLR200 | doi-access = free }} |
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Revision as of 19:18, 1 December 2020
Zinc finger protein 202 is a transcription factor first associated with breast cancer. It is a protein that, in humans, is encoded by the ZNF202 gene.[5][6]
Clinical significance
Variants of this protein have been discovered to be strongly associated with coronary heart disease and atherosclerosis.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000166261 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025602 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M (Sep 1998). "Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins". Genomics. 52 (3): 358–62. doi:10.1006/geno.1998.5419. PMID 9790754.
- ^ "Entrez Gene: ZNF202 zinc finger protein 202".
Further reading
- Iuchi, Shiro; Kuldell, Natalie (2005). Zinc finger proteins: from atomic contact to cellular function. Molecular biology intelligence unit. シュプリンガー・ジャパン
株式会社 . p. 161. ISBN 0-306-48229-0. - Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry. 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.
- Wagner S, Hess MA, Ormonde-Hanson P, Malandro J, Hu H, Chen M, Kehrer R, Frodsham M, Schumacher C, Beluch M, Honer C, Skolnick M, Ballinger D, Bowen BR (May 2000). "A broad role for the zinc finger protein ZNF202 in human lipid metabolism". The Journal of Biological Chemistry. 275 (21): 15685–90. doi:10.1074/jbc.M910152199. PMID 10748193.
- Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W, Honer C, Schumacher C, Schmitz G (Apr 2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". The Journal of Biological Chemistry. 276 (15): 12427–33. doi:10.1074/jbc.M100218200. PMID 11279031.
- Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal. 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A (Sep 2006). "Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study". Atherosclerosis. 188 (1): 43–50. doi:10.1016/j.atherosclerosis.2005.10.014. PMID 16289551.
- Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A (May 2006). "Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population". Journal of Lipid Research. 47 (5): 944–52. doi:10.1194/jlr.M500521-JLR200. PMID 16467280.
External links
- ZNF202+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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