Clemens van Blitterswijk

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Clemens van Blitterswijk
Clemens van Blitterswijk
Born1957
The Hague, Netherlands
Nationality Netherlands
Alma materUniversity of Leiden
AwardsJean Leray Award;

The Marie Parijs Award; The Klein Award;

George Winter Award; Huibregtsen Prize; Career Achievement Award;
Scientific career
FieldsBiomedical engineering, biomaterials, tissue engineering
InstitutionsUniversity of Maastricht

Clemens A. van Blitterswijk (1957, The Hague) is a Dutch scientist working in the field of tissue engineering, which aims to replace or regenerate diseased or damaged tissues through a combination of biology and engineering. In the past decades, he has contributed to several scientific discoveries, one of which is using synthetic biomaterials to heal bone injuries by triggering the body's cells to regenerate. Together with Hemant Unadkat and Jan de Boer, he also participated to the application of high-throughput techniques to deal with the complexity of designing biomaterials, termed "materiomics". Van Blitterswijk is an author on more than 430 peer-reviewed published papers (>18,000 citations, h-index 88; Web of Science).[1]

Career

van Blitterswijk graduated as cell biologist at Leiden University in 1982. He defended his PhD thesis in 1985 at the same university on artificial ceramic middle ear implants, for which he was awarded the Jean Leray young scientist award of the European Society for Biomaterials for outstanding research contribution.

In his research through the 1990s and 2000s, van Blitterswijk worked on novel biomaterials to heal bone injuries. He participated to developing a tissue engineering strategy termed osteoinduction that aims at designing biomaterials triggering stem cells in vivo to generate new bone tissue[2]. One example of this contribution is a paper published along with Joost de Bruijn and Huipin Yuan.[3] In 1997, he became professor at University of Twente, where he later participated to the foundation and directed the MIRA institute.[4] There, with Hemant Unadkat and Jan de Boer, he used more systematic and high-throughput approaches to discover micrometer-scale textures of biomaterial surfaces that aim at enhancing specific cellular functions, which resulted in the TopoChip[5][6] He was awarded an ERC Advanced grant in 2015 that aimed at developing micro-fabricated and microfluidic cell culture platforms to develop in vitro models of pancreatic islets, a pituitary gland, and an embryo model[7], and a NWO Gravitation[8] grant in 2017.[9]

Between 2014 and 2018, van Blitterswijk was the institute director, department chair and professor at the MERLN Institute for Technology-Inspired Regenerative Medicine[10] at Maastricht University (UM). He is currently one of the four distinguished professors at UM.[11]

Additionally, he founded and is leading an international consortium (Regenerative Medicine Crossing Borders; RegMed XB)[12] that aims to bring multiple cures for chronic diseases to market in the next ten years. He is a fellow of the International Union of Societies for Biomaterials Science and Engineering.[13] He has been a member of the Netherlands Academy of Technology and Innovation (AcTI)[14] 2003, the Royal Netherlands Academy of Arts and Sciences (KNAW) since 2012, and the Royal Holland Society of Sciences and Humanities (KHMW)[15] since 2016. He is on the editorial board of the Journal of Tissue Engineering and Regenerative Medicine.[16]

Valorization

Since the 1990s, van Blitterswijk has translated multiple technologies to commercial products. He is filled as an inventor on 34 patents[17], 15 clinical evaluations have been initiated and seven EC and/or FDA approvals awarded.

To date, van Blitterswijk has founded 10 companies and served as CEO (from 1996 to 2002) of IsoTis,[18] a publicly traded life sciences company. IsoTis subsequently suffered heavy financial losses in 2007 and was on the verge of bankruptcy before merging with Integra LifeSciences.[19][20]

He has been named the most entrepreneurial scientist in the Netherlands in 2012[21] and receiving the Huibregtsen award[22] for ground-breaking science with societal impact in 2015.

He is a founding partner of the Health Economics Funds (HEF) of the European health care investment group Life Sciences Partners[23] (LSP), a healthcare investment firms in Europe. The two HEF funds[24] have raised close to €400 million for technologies that aim at improving the quality of health care while lowering the cost of it, focused specifically on medical devices, diagnostics, and digital health. HEF2, at €280 million, is currently one of the largest fund in Europe dedicated to medical technology.

Teaching

Over his 30-year career, van Blitterswijk has been the official supervisor of over 70 PhD candidates through to their dissertation, and has participated to the edition of four textbooks, including the first dedicated to tissue engineering.[25]

Awards

Van Blitterswijk has won the following awards:

  • George Winter senior scientist award[26]
  • Career Achievement award of the EU Chapter of the Tissue Engineering and Regenerative Medicine International Society[27]
  • Federa award[28] for a major contribution in medical research
  • Huibregtsen award[22] for ground-breaking science with societal impact

Ten Major Publications

  • Levenberg S, Rouwkema J, Macdonald M, Garfein ES, Kohane DS, Darland DC, Marini R, van Blitterswijk CA, Mulligan RC, D'Amore PA, Langer R (July 2005). "Engineering vascularized skeletal muscle tissue". Nature Biotechnology. 23 (7): 879–84. doi:10.1038/nbt1109. PMID 15965465.
  • Moroni L, de Wijn JR, van Blitterswijk CA (March 2006). "3D fiber-deposited scaffolds for tissue engineering: influence of pores geometry and architecture on dynamic mechanical properties". Biomaterials. 27 (7): 974–85. doi:10.1016/j.biomaterials.2005.07.023. PMID 16055183.
  • Rouwkema J, de Boer J, Van Blitterswijk CA (September 2006). "Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct". Tissue Engineering. 12 (9): 2685–93. doi:10.1089/ten.2006.12.2685. PMID 16995802.
  • Meijer GJ, de Bruijn JD, Koole R, van Blitterswijk CA (February 2007). "Cell-based bone tissue engineering". PLOS Medicine. 4 (2): e9. doi:10.1371/journal.pmed.0040009. PMC 1800310. PMID 17311467.{{cite journal}}: CS1 maint: unflagged free DOI (link)</ref>
  • Jukes JM, Both SK, Leusink A, Sterk LM, van Blitterswijk CA, de Boer J (May 2008). "Endochondral bone tissue engineering using embryonic stem cells". Proceedings of the National Academy of Sciences of the United States of America. 105 (19): 6840–5. doi:10.1073/pnas.0711662105. PMC 2374550. PMID 18467492.
  • Siddappa R, Martens A, Doorn J, Leusink A, Olivo C, Licht R, van Rijn L, Gaspar C, Fodde R, Janssen F, van Blitterswijk C, de Boer J (May 2008). "cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo". Proceedings of the National Academy of Sciences of the United States of America. 105 (20): 7281–6. doi:10.1073/pnas.0711190105. PMC 2387183. PMID 18490653.
  • Yuan H, Fernandes H, Habibovic P, de Boer J, Barradas AM, de Ruiter A, Walsh WR, van Blitterswijk CA, de Bruijn JD (August 2010). "Osteoinductive ceramics as a synthetic alternative to autologous bone grafting". Proceedings of the National Academy of Sciences of the United States of America. 107 (31): 13614–9. doi:10.1073/pnas.1003600107. PMC 2922269. PMID 20643969.
  • Unadkat HV, Hulsman M, Cornelissen K, Papenburg BJ, Truckenmüller RK, Carpenter AE, Wessling M, Post GF, Uetz M, Reinders MJ, Stamatialis D, van Blitterswijk CA, de Boer J (October 2011). "An algorithm-based topographical biomaterials library to instruct cell fate". Proceedings of the National Academy of Sciences of the United States of America. 108 (40): 16565–70. doi:10.1073/pnas.1109861108. PMC 3189082. PMID 21949368.
  • Rivron NC, Vrij EJ, Rouwkema J, Le Gac S, van den Berg A, Truckenmüller RK, van Blitterswijk CA (May 2012). "Tissue deformation spatially modulates VEGF signaling and angiogenesis". Proceedings of the National Academy of Sciences of the United States of America. 109 (18): 6886–91. doi:10.1073/pnas.1201626109. PMC 3344996. PMID 22511716.
  • Danoux C, Sun L, Koçer G, Birgani ZT, Barata D, Barralet J, van Blitterswijk C, Truckenmüller R, Habibovic P (March 2016). "Development of Highly Functional Biomaterials by Decoupling and Recombining Material Properties". Advanced Materials. 28 (9): 1803–8. doi:10.1002/adma.201504589. PMID 26689847.

References

  1. ^ "Web of Science". Retrieved 1 February 2018.
  2. ^ Miron, R.J.; Zhang, Y.F. (2012-08). "Osteoinduction: A Review of Old Concepts with New Standards". Journal of Dental Research. 91 (8): 736–744. doi:10.1177/0022034511435260. ISSN 0022-0345. {{cite journal}}: Check date values in: |date= (help)
  3. ^ Yuan H, Fernandes H, Habibovic P, de Boer J, Barradas AM, de Ruiter A, Walsh WR, van Blitterswijk CA, de Bruijn JD (August 2010). "Osteoinductive ceramics as a synthetic alternative to autologous bone grafting". Proceedings of the National Academy of Sciences of the United States of America. 107 (31): 13614–9. doi:10.1073/pnas.1003600107. PMC 2922269. PMID 20643969.
  4. ^ "Technical Medical Centre". Universiteit Twente.
  5. ^ Unadkat HV, Hulsman M, Cornelissen K, Papenburg BJ, Truckenmüller RK, Carpenter AE, Wessling M, Post GF, Uetz M, Reinders MJ, Stamatialis D, van Blitterswijk CA, de Boer J (October 2011). "An algorithm-based topographical biomaterials library to instruct cell fate". Proceedings of the National Academy of Sciences of the United States of America. 108 (40): 16565–70. doi:10.1073/pnas.1109861108. PMC 3189082. PMID 21949368.
  6. ^ Baker M (November 2011). "Trying out topographies". Nature Methods. 8 (11): 900. doi:10.1038/nmeth.1760. PMID 22167818.
  7. ^ "Press release Maastricht University". Maastricht University. 8 April 2016.{{cite web}}: CS1 maint: url-status (link)
  8. ^ "Gravitation". nwo.nl.
  9. ^ Karolien. "More than 100 million euros for Dutch top science". nwo.nl. Retrieved 1 February 2018.
  10. ^ "Institute for Technology-Inspired Regenerative Medicine – Research – Maastricht University". maastrichtuniversity.nl.
  11. ^ "Distinguished university professors – Research – Maastricht University". maastrichtuniversity.nl. Retrieved 1 February 2018.
  12. ^ "Home – RegMed XB – Regenerative medicine crossing borders". regmedxb.com.
  13. ^ nnadilim. "HOME".
  14. ^ https://www.acti-nl.org/en/homepage?set_language=en since
  15. ^ https://khmw.nl/
  16. ^ "Journal of Tissue Engineering and Regenerative Medicine – Wiley Online Library". Journal of Tissue Engineering and Regenerative Medicine. doi:10.1002/(issn)1932-7005.
  17. ^ "Google Patents". patents.google.com. Retrieved 24 May 2020.
  18. ^ "IsoTis Orthobiologics Archives". SeaSpine.
  19. ^ "IsoTis – Integra Merger". Retrieved 30 September 2018.
  20. ^ "UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934". Retrieved 30 September 2018.
  21. ^ "News_van Blitterswijk most entrepreneurial scientist in 2012". Retrieved 1 February 2018.
  22. ^ a b "Over de prijs". avondwenm.nl.
  23. ^ "HOME". lspvc.com.
  24. ^ "FUNDS >> Private Franchise". lspvc.com.
  25. ^ https://www.amazon.com/dp/0123708699
  26. ^ "ESB European Society for Biomaterials". esbiomaterials.eu.
  27. ^ https://www.termis.org/chapters_eu.php
  28. ^ "Federaprijs-winnaars – Federa". federa.org.

External links

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