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Protein-coding gene in the species Homo sapiens
Glucosamine-6-phosphate deaminase 2 also known as GNPDA2 is an enzyme that in humans is encoded by the GNPDA2 gene .[ 5]
Clinical significance
Variants of the GNPDA2 gene may be associated with obesity .[ 6] [ 7] [ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000163281 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029209 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Arreola R, Valderrama B, Morante ML, Horjales E (September 2003). "Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study" . FEBS Lett . 551 (1–3): 63–70. doi :10.1016/S0014-5793(03)00896-2 PMID 12965206 . S2CID 45050024 . ^ Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI" . Obesity (Silver Spring) . 17 (12): 2254–7. doi :10.1038/oby.2009.159 . PMC 2860782 PMID 19478790 . ^ Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, Barroso I, Nordström P, Franks PW (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden" . Hum. Mol. Genet . 18 (8): 1489–96. doi :10.1093/hmg/ddp041 . PMC 2664142 PMID 19164386 . ^ Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation" . Nat. Genet . 41 (1): 25–34. doi :10.1038/ng.287 . PMC 2695662 PMID 19079261 .
Further reading
Bauer F, Elbers CC, Adan RA, et al. (2009). "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference" . Am. J. Clin. Nutr . 90 (4): 951–9. doi :10.3945/ajcn.2009.27781 PMID 19692490 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Haupt A, Thamer C, Heni M, et al. (2009). "Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study" . Obesity (Silver Spring) . 18 (6): 1212–7. doi :10.1038/oby.2009.413 PMID 19910938 . S2CID 9601431 . Li S, Zhao JH, Luan J, et al. (2010). "Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies" . Am. J. Clin. Nutr . 91 (1): 184–90. doi :10.3945/ajcn.2009.28403 PMID 19812171 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Brandys MK, van Elburg AA, Loos RJ, et al. (2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". Am. J. Med. Genet. B Neuropsychiatr. Genet . 153B (2): 695–9. doi :10.1002/ajmg.b.31026 . PMID 19746409 . S2CID 45793585 . Renström F, Payne F, Nordström A, et al. (2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden" . Hum. Mol. Genet . 18 (8): 1489–96. doi :10.1093/hmg/ddp041 . PMC 2664142 PMID 19164386 . He M, Cornelis MC, Franks PW, et al. (2010). "Obesity Genotype Score and Cardiovascular Risk in Women with Type 2 Diabetes" . Arterioscler. Thromb. Vasc. Biol . 30 (2): 327–32. doi :10.1161/ATVBAHA.109.196196 . PMC 3061473 PMID 19910641 . Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome" . Mol. Cell. Proteomics . 7 (3): 499–508. doi :10.1074/mcp.M700325-MCP200 PMID 18029348 . Hotta K, Nakamura M, Nakamura T, et al. (2009). "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population" . J. Hum. Genet . 54 (12): 727–31. doi :10.1038/jhg.2009.106 PMID 19851340 .
