34β E12
Appearance
34
It is sometimes, less precisely, referred to as high-molecular weight keratin (HMWK) and high-molecular weight cytokeratin (HMWCK).
Utility
[edit]It is used to stain basal cells in prostatic glands; loss of basal cells is seen in prostate adenocarcinoma (the most common form of prostate cancer).
It can be used to differentiate in situ cancers of the breast; lobular carcinoma in situ (LCIS) exhibits perinuclear staining with 34
See also
[edit]References
[edit]- ^ Aishima S, Asayama Y, Taguchi K, et al. (November 2002). "The utility of keratin 903 as a new prognostic marker in mass-forming-type intrahepatic cholangiocarcinoma". Mod. Pathol. 15 (11): 1181–90. doi:10.1097/01.MP.0000032537.82380.69. PMID 12429797. S2CID 13065115.
- ^ a b Yeh IT, Mies C (March 2008). "Application of immunohistochemistry to breast lesions". Arch. Pathol. Lab. Med. 132 (3): 349–358. doi:10.5858/2008-132-349-AOITBL. PMID 18318578.