Death receptor 6
Death receptor 6 (DR6), also known as tumor necrosis factor receptor superfamily member 21 (TNFRSF21), is a cell surface receptor of the tumor necrosis factor receptor superfamily which activates the JNK and NF-
Function
[edit]The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-
Clinical significance
[edit]The free serum levels of this DR6 are heightened with anti-cell death factors in patients that have later stage ovarian cancer.[10]
DR6 is also thought to be involved in neurodegeneration in the brain that causes Alzheimer's disease as well as signal transduction in stress response and cellular survival.[11] DR6 induces apoptosis when it is over expressed, however the manner in which the death signal is intracellularly transduced is currently unknown. It has been determined that Bax translocation is necessary for the apoptosis triggered by DR6, but through an unknown pathway instead of the traditional pathways of intrinsic versus extrinsic.[citation needed] APP (amyloid precursor protein) is the natural ligand of DR6 and is first cleaved into A
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000146072 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023915 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM (July 1998). "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor" (PDF). FEBS Letters. 431 (3): 351–6. doi:10.1016/S0014-5793(98)00791-1. hdl:2027.42/116991. PMID 9714541. S2CID 11151198.
- ^ a b "Entrez Gene: TNFRSF21 tumor necrosis factor receptor superfamily, member 21".
- ^ Salido GM, Rosado JA (2009). Apoptosis: Involvement of Oxidative Stress and Intracellular Ca2+ Homeostasis. Heidelberg, Germany: Springer. p. 37. ISBN 9781402098734.
- ^ Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, et al. (October 2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
- ^ Daniel PT, Wieder T, Sturm I, Schulze-Osthoff K (2001). "The kiss of death: promises and failures of death receptors and ligands in cancer therapy". Leukemia. 15 (7): 1022–32. doi:10.1038/sj.leu.2402169. PMID 11455969. S2CID 24538645.
- ^ Sasaroli D, Gimotty PA, Pathak HB, Hammond R, Kougioumtzidou E, Katsaros D, Buckanovich R, Devarajan K, Sandaltzopoulos R, Godwin AK, Scholler N, Coukos G (2011). "Novel surface targets and serum biomarkers from the ovarian cancer vasculature". Cancer Biology & Therapy. 12 (3): 169–80. doi:10.4161/cbt.12.3.16260. PMC 3230481. PMID 21617380.
- ^ Kuester M, Kemmerzehl S, Dahms SO, Roeser D, Than ME (June 2011). "The crystal structure of death receptor 6 (DR6): a potential receptor of the amyloid precursor protein (APP)". Journal of Molecular Biology. 409 (2): 189–201. doi:10.1016/j.jmb.2011.03.048. PMID 21463639.
- ^ Osherovich L (2009). "Genentech's new parADigm". Science-Business EXchange. 2 (8): 1–5. doi:10.1038/scibx.2009.300.
Further reading
[edit]- Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM (July 1998). "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor" (PDF). FEBS Letters. 431 (3): 351–6. doi:10.1016/S0014-5793(98)00791-1. hdl:2027.42/116991. PMID 9714541. S2CID 11151198.
- Liu J, Na S, Glasebrook A, Fox N, Solenberg PJ, Zhang Q, Song HY, Yang DD (July 2001). "Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice". Immunity. 15 (1): 23–34. doi:10.1016/S1074-7613(01)00162-5. PMID 11485735.
- Zhao H, Yan M, Wang H, Erickson S, Grewal IS, Dixit VM (November 2001). "Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice". The Journal of Experimental Medicine. 194 (10): 1441–8. doi:10.1084/jem.194.10.1441. PMC 2193683. PMID 11714751.
- Kasof GM, Lu JJ, Liu D, Speer B, Mongan KN, Gomes BC, Lorenzi MV (November 2001). "Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB". Oncogene. 20 (55): 7965–75. doi:10.1038/sj.onc.1204985. PMID 11753679. S2CID 25063448.
- Mai T, Wang X, Zhang Z, Xin D, Na Y, Guo Y (October 2004). "Androgen receptor coregulator ARA267-alpha interacts with death receptor-6 revealed by the yeast two-hybrid". Science in China Series C: Life Sciences. 47 (5): 442–8. doi:10.1360/03yc0214. PMID 15623156.
- Klíma M, Zájedová J, Doubravská L, Andera L (October 2009). "Functional analysis of the posttranslational modifications of the death receptor 6". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1793 (10): 1579–87. doi:10.1016/j.bbamcr.2009.07.008. PMID 19654028.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.