Hefutoxin
Hefutoxin family | |||||||||
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Identifiers | |||||||||
Symbol | Toxin_25 | ||||||||
Pfam | PF08095 | ||||||||
InterPro | IPR012630 | ||||||||
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Kappa- Hefutoxin 1 and 2 are toxins from the venom of the Asian forest black scorpion Heterometrus fulvipes with a unique structure. It blocks the potassium channels Kv1.2 and Kv1.3 and slows the activation of Kv1.3.
Source
[edit]The kappa- Hefutoxin 1 and 2 (
Chemistry
[edit]The structure of the toxin is unique because it is made up of two anti-parallel helices linked by two disulfide bridges without
Target and mode of action
[edit]The toxin blocks the voltage-gated potassium channel Kv1.2 and not only blocks the Kv1.3 channels but also slows down their activation kinetics. The blocking effect is most effective when the K+ ions flow inward thus at a negative potential.<[1] [2]
References
[edit]- ^ a b c d Srinivasan KN, Sivaraja V, Huys I, Sasaki T, Cheng B, Kumar TK, et al. (August 2002). "kappa-Hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity". The Journal of Biological Chemistry. 277 (33): 30040–30047. doi:10.1074/jbc.M111258200. PMID 12034709.
- ^ Zarrabi M, Naderi-Manesh H (2007). "Computational simulations of interactions of the
κ -hefutoxin1 with the voltage-gated potassium ion channels". BMC Systems Biology. 1 (Suppl 1): P36. doi:10.1186/1752-0509-1-S1-P36.