Integrin beta 5

ITGB5
Identifiers
Aliases	ITGB5, Integrin, beta 5, integrin subunit beta 5
External IDs	OMIM: 147561; MGI: 96614; HomoloGene: 20511; GeneCards: ITGB5; OMA:ITGB5 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	124,901,418 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	33,769,708 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right coronary artery; ; ascending aorta; ; Descending thoracic aorta; ; pancreatic ductal cell; ; tendon of biceps brachii; ; cartilage tissue; ; left coronary artery; ; metanephric glomerulus; ; popliteal artery;
	Top expressed in
	tunica media of zone of aorta; ; epithelium of lens; ; decidua; ; calvaria; ; ciliary body; ; molar; ; external carotid artery; ; gastrula; ; stria vascularis; ; stroma of bone marrow;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; protein binding; integrin binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; focal adhesion; receptor complex; plasma membrane; cell surface; integrin complex; phagocytic vesicle; integrin alphav-beta5 complex; extracellular exosome;
Biological process	muscle contraction; endodermal cell differentiation; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; extracellular matrix organization; epithelial cell-cell adhesion; stress fiber assembly; cell adhesion; integrin-mediated signaling pathway; viral entry into host cell; cell-matrix adhesion; viral process; transforming growth factor beta receptor signaling pathway; cell migration; cell adhesion mediated by integrin;
	Sources:Amigo / QuickGO
Orthologs
	3693
	16419
	ENSG00000082781
	ENSMUSG00000022817
	P18084
	O70309
	NM_002213; NM_001354764; NM_001354765; NM_001354766
	NM_001145884; NM_010580
	NP_002204; NP_001341693; NP_001341694; NP_001341695
	NP_001139356; NP_034710; NP_001391992
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.^[5]^[6]

Interactions

Integrin, beta 5 has been shown to interact with PTK2,^[7] Annexin A5^[8] and PAK4.^[9]

Functions

ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.^[10]

Clinical significance

Research

Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000082781 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022817 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. doi:10.1016/S0021-9258(17)44878-2. PMID 2211615.
^ "Entrez Gene: ITGB5 integrin, beta 5".
^ Eliceiri BP, Puente Xose S, Hood John D, Stupack Dwayne G, Schlaepfer David D, Huang Xiaozhu Z, Sheppard Dean, Cheresh David A (Apr 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263. PMID 11927607.
^ Cardó-Vila M, Arap Wadih, Pasqualini Renata (May 2003). "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell. 11 (5): 1151–62. doi:10.1016/S1097-2765(03)00138-2. ISSN 1097-2765. PMID 12769841.
^ Zhang H, Li Zhilun, Viklund Eva-Karin, Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN 0021-9525. PMC 2173231. PMID 12356872.
^ Zhang Ly, Guo Q, Guan Gf, Cheng W, Cheng P, Wu Ah (2019). "Integrin Beta 5 Is a Prognostic Biomarker and Potential Therapeutic Target in Glioblastoma". Frontiers in Oncology. 9: 904. doi:10.3389/fonc.2019.00904. ISSN 2234-943X. PMC 6764112. PMID 31616629.
^ Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology" (PDF). Lab. Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069. S2CID 5097233.

Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays. 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216. S2CID 23712246.
Smith JW, Vestal DJ, Irwin SV, et al. (1990). "Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin". J. Biol. Chem. 265 (19): 11008–13. doi:10.1016/S0021-9258(19)38549-7. PMID 1694173.
Adams JC, Watt FM (1991). "Expression of beta 1, beta 3, beta 4, and beta 5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes". J. Cell Biol. 115 (3): 829–41. doi:10.1083/jcb.115.3.829. PMC 2289188. PMID 1918165.
Ramaswamy H, Hemler ME (1990). "Cloning, primary structure and properties of a novel human integrin beta subunit". EMBO J. 9 (5): 1561–8. doi:10.1002/j.1460-2075.1990.tb08275.x. PMC 551850. PMID 2328726.
Suzuki S, Huang ZS, Tanihara H (1990). "Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit". Proc. Natl. Acad. Sci. U.S.A. 87 (14): 5354–8. Bibcode:1990PNAS...87.5354S. doi:10.1073/pnas.87.14.5354. PMC 54322. PMID 2371275.
Hu DD, Lin EC, Kovach NL, et al. (1995). "A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5". J. Biol. Chem. 270 (44): 26232–8. doi:10.1074/jbc.270.44.26232. PMID 7592829.
Vogel BE, Lee SJ, Hildebrand A, et al. (1993). "A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin". J. Cell Biol. 121 (2): 461–8. doi:10.1083/jcb.121.2.461. PMC 2200091. PMID 7682219.
Pasqualini R, Bodorova J, Ye S, Hemler ME (1993). "A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies". J. Cell Sci. 105 (1): 101–11. doi:10.1242/jcs.105.1.101. PMID 7689573.
Lafrenie RM, Wahl LM, Epstein JS, et al. (1996). "HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes". Journal of Immunology. 157 (3): 974–7. doi:10.4049/jimmunol.157.3.974. PMID 8757599.
Rabb H, Barroso-Vicens E, Adams R, et al. (1997). "Alpha-V/beta-3 and alpha-V/beta-5 integrin distribution in neoplastic kidney". Am. J. Nephrol. 16 (5): 402–8. doi:10.1159/000169032. PMID 8886177.
Liliental J, Chang DD (1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. PMID 9442085.
Memmo LM, McKeown-Longo P (1998). "The alphavbeta5 integrin functions as an endocytic receptor for vitronectin". J. Cell Sci. 111 (4): 425–33. doi:10.1242/jcs.111.4.425. PMID 9443892.
Zhang H, Tan SM, Lu J (1998). "cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing". Biochem. J. 331 (2): 631–7. doi:10.1042/bj3310631. PMC 1219398. PMID 9531507.
Barillari G, Sgadari C, Palladino C, et al. (1999). "Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin". Journal of Immunology. 163 (4): 1929–35. doi:10.4049/jimmunol.163.4.1929. PMID 10438928.
Carriero MV, Del Vecchio S, Capozzoli M, et al. (1999). "Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer". Cancer Res. 59 (20): 5307–14. PMID 10537314.
Tang S, Gao Y, Ware JA (1999). "Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent protein". J. Cell Biol. 147 (5): 1073–84. doi:10.1083/jcb.147.5.1073. PMC 2169340. PMID 10579726.
Cirulli V, Beattie GM, Klier G, et al. (2000). "Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells". J. Cell Biol. 150 (6): 1445–60. doi:10.1083/jcb.150.6.1445. PMC 2150716. PMID 10995448.
Albert ML, Kim JI, Birge RB (2001). "alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells". Nat. Cell Biol. 2 (12): 899–905. doi:10.1038/35046549. PMID 11146654. S2CID 7535200.
Zhou M, Graham R, Russell G, Croucher PI (2001). "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc.2000.4155. PMID 11162558.
Niu JK, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion". Eur J Cancer Prev. 16 (6): 517–27. doi:10.1097/CEJ.0b013e3280145c00. PMID 18090124. S2CID 1825380.

External links

ITGB5 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000082781 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022817 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2211615-5] McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. doi:10.1016/S0021-9258(17)44878-2. PMID 2211615.

[entrez-6] "Entrez Gene: ITGB5 integrin, beta 5".

[pmid11927607-7] Eliceiri BP, Puente Xose S, Hood John D, Stupack Dwayne G, Schlaepfer David D, Huang Xiaozhu Z, Sheppard Dean, Cheresh David A (Apr 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263. PMID 11927607.

[pmid12769841-8] Cardó-Vila M, Arap Wadih, Pasqualini Renata (May 2003). "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell. 11 (5): 1151–62. doi:10.1016/S1097-2765(03)00138-2. ISSN 1097-2765. PMID 12769841.

[pmid12356872-9] Zhang H, Li Zhilun, Viklund Eva-Karin, Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN 0021-9525. PMC 2173231. PMID 12356872.

[10] Zhang Ly, Guo Q, Guan Gf, Cheng W, Cheng P, Wu Ah (2019). "Integrin Beta 5 Is a Prognostic Biomarker and Potential Therapeutic Target in Glioblastoma". Frontiers in Oncology. 9: 904. doi:10.3389/fonc.2019.00904. ISSN 2234-943X. PMC 6764112. PMID 31616629.

[pmid_=_24336069-11] Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology" (PDF). Lab. Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069. S2CID 5097233.

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