Integrin beta 7
Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene.[5][6] It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor
Structure
[edit]Like all integrin subunits,
Interactions
[edit]ITGB7 has been shown to interact with EED.[10]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000139626 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001281 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Erle DJ, Rüegg C, Sheppard D, Pytela R (Jun 1991). "Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes". The Journal of Biological Chemistry. 266 (17): 11009–16. doi:10.1016/S0021-9258(18)99120-9. PMID 2040616.
- ^ "Entrez Gene: ITGB7 integrin, beta 7".
- ^ Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ (Nov 2009). "Anti-integrin monoclonal antibodies". Journal of Cell Science. 122 (Pt 22): 4009–11. doi:10.1242/jcs.056770. PMC 3329622. PMID 19910492.
- ^ Carman CV, Springer TA (Oct 2003). "Integrin avidity regulation: are changes in affinity and conformation underemphasized?". Current Opinion in Cell Biology. 15 (5): 547–56. doi:10.1016/j.ceb.2003.08.003. PMID 14519389.
- ^ Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA (Jan 2012). "Structural specializations of
α (4)β (7), an integrin that mediates rolling adhesion". The Journal of Cell Biology. 196 (1): 131–46. doi:10.1083/jcb.201110023. PMC 3255974. PMID 22232704. - ^ Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (Oct 1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". The Journal of Biological Chemistry. 273 (42): 27459–66. doi:10.1074/jbc.273.42.27459. PMID 9765275.
Further reading
[edit]- Rüegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ (Apr 1992). "Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering". The Journal of Cell Biology. 117 (1): 179–89. doi:10.1083/jcb.117.1.179. PMC 2289398. PMID 1372909.
- Chan BM, Elices MJ, Murphy E, Hemler ME (Apr 1992). "Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY". The Journal of Biological Chemistry. 267 (12): 8366–70. doi:10.1016/S0021-9258(18)42453-2. PMID 1373725.
- Jiang WM, Jenkins D, Yuan Q, Leung E, Choo KH, Watson JD, Krissansen GW (Sep 1992). "The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1". International Immunology. 4 (9): 1031–40. doi:10.1093/intimm/4.9.1031. PMID 1382574.
- Baker E, Sutherland GR, Jiang WM, Yuan Q, Leung E, Watson JD, Krissansen GW (1992). "Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13 by non-isotopic in situ hybridization". Mammalian Genome. 2 (4): 272–3. doi:10.1007/BF00355438. PMID 1543919. S2CID 30346801.
- Yuan QA, Jiang WM, Krissansen GW, Watson JD (Dec 1991). "Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains". International Immunology. 3 (12): 1373–4. doi:10.1093/intimm/3.12.1373. PMID 1777426.
- Yuan QA, Jiang WM, Krissansen GW, Watson JD (1991). "Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains". International Immunology. 2 (11): 1097–108. doi:10.1093/intimm/2.11.1097. PMID 2083230.
- Erle DJ, Brown T, Christian D, Aris R (Mar 1994). "Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression". American Journal of Respiratory Cell and Molecular Biology. 10 (3): 237–44. doi:10.1165/ajrcmb.10.3.7509610. PMID 7509610.
- Postigo AA, Sánchez-Mateos P, Lazarovits AI, Sánchez-Madrid F, de Landázuri MO (Sep 1993). "Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes". Journal of Immunology. 151 (5): 2471–83. doi:10.4049/jimmunol.151.5.2471. PMID 7689608.
- Shaw SK, Cepek KL, Murphy EA, Russell GJ, Brenner MB, Parker CM (Feb 1994). "Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution". The Journal of Biological Chemistry. 269 (8): 6016–25. doi:10.1016/S0021-9258(17)37563-4. PMID 8119947.
- Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ (Aug 1997). "Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1". Journal of Immunology. 159 (3): 1497–505. doi:10.4049/jimmunol.159.3.1497. PMID 9233649.
- Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH (Jun 1998). "The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition". Structure. 6 (6): 793–801. doi:10.1016/S0969-2126(98)00080-X. PMID 9655832.
- Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (Oct 1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". The Journal of Biological Chemistry. 273 (42): 27459–66. doi:10.1074/jbc.273.42.27459. PMID 9765275.
- Taraszka KS, Higgins JM, Tan K, Mandelbrot DA, Wang JH, Brenner MB (May 2000). "Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin". The Journal of Experimental Medicine. 191 (9): 1555–67. doi:10.1084/jem.191.9.1555. PMC 2213439. PMID 10790430.
- Higgins JM, Cernadas M, Tan K, Irie A, Wang J, Takada Y, Brenner MB (Aug 2000). "The role of alpha and beta chains in ligand recognition by beta 7 integrins". The Journal of Biological Chemistry. 275 (33): 25652–64. doi:10.1074/jbc.M001228200. PMID 10837471.
- Puig-Kröger A, Sanz-Rodríguez F, Longo N, Sánchez-Mateos P, Botella L, Teixidó J, Bernabéu C, Corbí AL (Oct 2000). "Maturation-dependent expression and function of the CD49d integrin on monocyte-derived human dendritic cells". Journal of Immunology. 165 (8): 4338–45. doi:10.4049/jimmunol.165.8.4338. PMID 11035069.
- Guilliano MJ, Foxx-Orenstein AE, Lebman DA (Feb 2001). "The microenvironment of human Peyer's patches inhibits the increase in CD38 expression associated with the germinal center reaction". Journal of Immunology. 166 (4): 2179–85. doi:10.4049/jimmunol.166.4.2179. PMID 11160270. S2CID 36075610.
- Calderwood DA, Huttenlocher A, Kiosses WB, Rose DM, Woodside DG, Schwartz MA, Ginsberg MH (Dec 2001). "Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration". Nature Cell Biology. 3 (12): 1060–8. doi:10.1038/ncb1201-1060. PMID 11781567. S2CID 6459957.
- Calderwood DA, Fujioka Y, de Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg MH (Mar 2003). "Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2272–7. Bibcode:2003PNAS..100.2272C. doi:10.1073/pnas.262791999. PMC 151330. PMID 12606711.
External links
[edit]- ITGB7 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine