KIAA1958
| KIAA1958 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | KIAA1958 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 617390; MGI: 2442164; HomoloGene: 136743; GeneCards: KIAA1958; OMA:KIAA1958 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Protein KIAA1958 is a protein that in humans is encoded by the KIAA1958 gene.[5] Orthologs of KIAA1958 go as far back in evolution to chordates, although, it is closer in homology to primates than any other orthologs. KIAA1958 has no known paralogs.
Gene
[edit]KIAA1958 is located on the long arm of chromosome 9 (9.q32) in humans on the plus strand from 115249248 to 115427597.[6] Its mRNA has 2683 bp.[5] The gene has these neighbors on chromosome 9:
HSDL2: Hydroxysteroid dehydrogenase-like protein 2 plays a role in nucleotide binding, oxidoreductase activity, and sterol binding.[7]
C9orf147: Chromosome 9 open reading frame 147 has an unknown function.[8]
C9orf80: Chromosome 9 open reading frame 80 is a component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell cycle checkpoint activation, recombinational repair and maintenance of genomic stability.[9]
SNX30: Sorting nexin-30 may be linked to phosphatidylinositol binding.[10]
Expression
[edit]KIAA1958 is expressed in the highest quantities in the larynx as proposed by EST.[11] The highest expression in developmental stage is the blastocyst and for health state, it is most found in uterine tumors.[11] Data from NCBI GEO Profile[12] shows that KIAA1958 expression includes many of the tissue types in the human body. Using EMBL-EBI, KIAA1958 was found to be overexpressed in pseudopod RNA during the migration of the metastatic cancer cells.[13] KIAA1958 was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth and viability of prostate cancer cells[13] and both the embryonic stem cell and the pluripotent stem cell.[13]
Protein
[edit]
KIAA1958 is composed of 716 amino acids and weighs 79212 Da with an iso-electric point of 6.375.[14] Although not much is known about the KIAA1958 protein, scientific predictions have been made using supercomputers for predictions of KIAA1958's structure and function. KIAA1958 undergoes post-translational modifications. The most interesting modification is phosphorylation. In comparison to other proteins, KIAA1958 has a substantially significant amount of serines phosphorylated during post-translational modification. 36 serines are predicted to be phosphorylated.
Structure
[edit]PELE on SDSC Biology WorkBench is supercomputer that is able to predict secondary structure of the KIAA1958 protein.[15] According to this tool, the protein's secondary structure is a combination of alpha helices and beta sheets, in almost equal amount and spread out almost evenly throughout the protein.
Interactions
[edit]There is no known proof that KIAA1958 interacts with any other proteins at this time.[16]
Homology
[edit]| Genus and Species | Common Name | Accession Number | Seq. Length | Seq. Identity | Seq. Similarity |
| Pan troglodytes | Chimpanzee | XM_528391 | 7945 bp | 99% | 99% |
| Mus musculus | Mouse | BAC38268 | 719 a | 97% | 98% |
| Callithrix jacchus | Common marmoset | XM_002743204 | 2346bp | 97% | 82% |
| Pongo abelii | Sumatran Orangutan | XM_002820112 | 1120bp | 96% | 4% |
| Sus scrofa | Wild boar | XM_003122070 | 2502 bp | 93% | 81% |
| Ailuropoda melanoleuca | Giant Panda | XM_002925938 | 2151 bp | 85% | 91% |
| Nomascus leucogenys | White cheeked gibbon | XM_003263945 | 950 bp | 93% | 5% |
| Oryctolagus cuniculus | European rabbit | XM_002707990 | 2223 bp | 93% | 43% |
| Loxodonta africana | African bush elephant | XM_003407521 | 2388 bp | 93% | 80% |
| Cricetulus griseus | Chinese hamster | XM_003505508 | 2534 bp | 92% | 42% |
| Equus caballus | Horse | XM_001916302 | 2536 bp | 91% | 93% |
| Bos taurus | Cow | XM_876102.5 | 2480 bp | 91% | 81% |
| Rattus norvegicus | Rat | XM_002726532 | 1364 bp | 91% | 36% |
| Cavia porcellus | Guinea pig | XM_003463791 | 2217 bp | 91% | 43% |
| Monodelphis domestica | Opossum | XM_001375976 | 2217 bp | 78% | 41% |
| Branchiostoma floridae | Lancelet | XP_002611438 | 719 a | 29% | 48% |
| Amphimedon queenslandica | Sponge | XP_003390994 | 388 a | 25% | 48% |
| Acyrthosiphon pisum | Pea aphid | XP_001943720 | 1197 aa | 24% | 43% |
| Oikopleura dioica | Chordate | CBY34656 | 629 a | 22% | 43% |
| Ciona intestinalis | Vase tunicate | XP_002125964 | 1004 aa | 23% | 43% |
| Xenopus (silurana) tropicalis | Western Clawed frog | AAI61073 | 679 a | 23% | 43% |
| Halocynthia roretzi | Sea pineapple | BAB40645 | 980 a | 23% | 45% |
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000165185 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045071 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Homo sapiens KIAA1958 (KIAA1958), mRNA". NCBI. Retrieved 20 April 2012.
- ^ "Homo sapiens gene KIAA1958, encoding KIAA1958". AceView. Retrieved 19 April 2012.
- ^ "Q6YN16 (HSDL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot". UniProt. Retrieved 1 May 2012.
- ^ "Homo sapiens gene C9orf147, encoding chromosome 9 open reading frame 147". AceView. Retrieved 1 May 2012.
- ^ "Q9NRY2 (SOSSC_HUMAN) Reviewed, UniProtKB/Swiss-Prot". Retrieved 1 May 2012.
- ^ "Q5VWJ9 (SNX30_HUMAN) Reviewed, UniProtKB/Swiss-Prot". Retrieved 1 May 2012.
- ^ a b "Unigene EST profile". Unigene. Retrieved 8 May 2012.
- ^ "Geo Profiles". NCBI. Retrieved 28 April 2012.
- ^ a b c "Gene Expression Profiles". Embl-Ebi. Retrieved 8 May 2012.
- ^ "Biology WorkBench". SDSC. Retrieved 3 May 2012.
- ^ "Biology Workbench". SDSC Biology WorkBench. Retrieved 28 April 2012.
- ^ "Protein Interactions". String. Retrieved 7 May 2012.
Further reading
[edit]- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.