RCC2

RCC2
Identifiers
Aliases	RCC2, TD-60, regulator of chromosome condensation 2
External IDs	OMIM: 609587; MGI: 1919784; HomoloGene: 10282; GeneCards: RCC2; OMA:RCC2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	17,439,677 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	140,450,531 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; lymph node; ; monocyte; ; skin of abdomen; ; stromal cell of endometrium; ; ventricular zone; ; skin of leg; ; appendix; ; granulocyte; ; gonad;
	Top expressed in
	ventricular zone; ; primitive streak; ; somite; ; epiblast; ; thymus; ; abdominal wall; ; fetal liver hematopoietic progenitor cell; ; ganglionic eminence; ; medial ganglionic eminence; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein domain specific binding; microtubule binding; small GTPase binding; protein binding; protein kinase binding; RNA binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; early endosome membrane; membrane; plasma membrane; spindle; chromosome, centromeric core domain; chromosome; mitotic spindle midzone; midbody; nucleolus; microtubule; chromosome, centromeric region; cytoskeleton; nucleus;
Biological process	regulation of cell migration; activation of GTPase activity; establishment of protein localization; cell division; chromosome passenger complex localization to kinetochore; positive regulation of attachment of spindle microtubules to kinetochore; focal adhesion assembly; negative regulation of GTPase activity; regulation of ruffle assembly; integrin-mediated signaling pathway; positive regulation of G2/M transition of mitotic cell cycle; cell cycle; negative regulation of substrate adhesion-dependent cell spreading; regulation of fibroblast migration; negative regulation of focal adhesion assembly; sister chromatid cohesion;
	Sources:Amigo / QuickGO
Orthologs
	55920
	108911
	ENSG00000281540; ENSG00000179051
	ENSMUSG00000040945
	Q9P258
	Q8BK67
	NM_018715; NM_001136204
	NM_173867
	NP_001129676; NP_061185; NP_001129676.1; NP_061185.1
	NP_776292
	Wikidata
View/Edit Human	View/Edit Mouse

Protein RCC2 also known as telophase disk protein of 60 kDa (TD-60) or RCC1-like protein TD-60 is a protein that in humans is encoded by the RCC2 gene.^[5]^[6]^[7]

Function

RCC2 has structural similarity to RCC1, and has been shown to have weak guanine nucleotide exchange factor (GEF) activity on the small GTPase Rac.^[6] TD-60 has also been shown to interact with the Chromosomal Passenger Complex (CPC), and to activate the catalytic component of the CPC, Aurora B, in the presence of microtubules.^[8]^[9]

References

^ ^a ^b ^c ENSG00000179051 GRCh38: Ensembl release 89: ENSG00000281540, ENSG00000179051 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040945 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
^ ^a ^b Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman JP, Margolis RL (Aug 2003). "The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression". Dev Cell. 5 (2): 295–307. doi:10.1016/S1534-5807(03)00205-3. PMID 12919680.
^ "Entrez Gene: RCC2 regulator of chromosome condensation 2".
^ Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (July 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.
^ Rosasco-Nitcher SE, Lan W, Khorasanizadeh S, Stukenberg PT (January 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science. 319 (5862): 469–72. Bibcode:2008Sci...319..469R. doi:10.1126/science.1148980. PMID 18218899. S2CID 10374348.

External links

Overview of all the structural information available in the PDB for UniProt: Q9P258 (Protein RCC2) at the PDBe-KB.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000179051 GRCh38: Ensembl release 89: ENSG00000281540, ENSG00000179051 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040945 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10819331-5] Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

[pmid12919680-6] Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman JP, Margolis RL (Aug 2003). "The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression". Dev Cell. 5 (2): 295–307. doi:10.1016/S1534-5807(03)00205-3. PMID 12919680.

[entrez-7] "Entrez Gene: RCC2 regulator of chromosome condensation 2".

[pmid15249581-8] Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (July 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.

[pmid18218899-9] Rosasco-Nitcher SE, Lan W, Khorasanizadeh S, Stukenberg PT (January 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science. 319 (5862): 469–72. Bibcode:2008Sci...319..469R. doi:10.1126/science.1148980. PMID 18218899. S2CID 10374348.

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[2]

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[5]

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[8]

[9]

Function

References

Further reading

External links