SART3

SART3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DO4, 5JJW, 5JJX, 5CTT, 5CTR, 5JPZ, 5CTQ
Identifiers
Aliases	SART3, DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb), squamous cell carcinoma antigen recognized by T-cells 3, squamous cell carcinoma antigen recognized by T cells 3, spliceosome associated factor 3, U4/U6 recycling protein
External IDs	OMIM: 611684; MGI: 1858230; HomoloGene: 40977; GeneCards: SART3; OMA:SART3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q23.3 Start 108,522,214 bp End 108,561,400 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 113,880,507 bp End 113,910,571 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell secondary oocyte tendon of biceps brachii sural nerve Achilles tendon nipple internal globus pallidus cerebellar hemisphere cerebellar vermis epithelium of colon Top expressed in tail of embryo zygote neural layer of retina oocyte primary oocyte secondary oocyte genital tubercle epiblast ventricular zone lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function U6atac snRNA binding histone binding U4 snRNA binding protein binding nucleic acid binding ubiquitin-specific protease binding U6 snRNA binding RNA binding Cellular component cytoplasm Cajal body nuclear speck U4/U6 x U5 tri-snRNP complex nucleoplasm U4/U6 snRNP U6atac snRNP U4atac/U6atac snRNP nucleus ASAP complex Biological process mRNA splicing, via spliceosome nucleosome assembly RNA processing spliceosomal tri-snRNP complex assembly homeostasis of number of cells positive regulation of histone deubiquitination hematopoietic stem cell proliferation mRNA processing spliceosomal snRNP assembly cell morphogenesis RNA splicing regulation of gene expression regulation of alternative mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9733 53890 Ensembl ENSG00000075856 ENSMUSG00000018974 UniProt Q15020 Q9JLI8 RefSeq (mRNA) NM_014706 NM_016926 NM_001356621 NM_001356623 RefSeq (protein) NP_055521 NP_058622 NP_001343550 NP_001343552 Location (UCSC) Chr 12: 108.52 – 108.56 Mb Chr 5: 113.88 – 113.91 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.

Interactions

SART3 has been shown to interact with RNPS1 and Androgen receptor.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Yang D, Nakao M, Shichijo S, Sasatomi T, Takasu H, Matsumoto H, Mori K, Hayashi A, Yamana H, Shirouzu K, Itoh K (August 1999). "Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients". Cancer Research. 59 (16): 4056–63. PMID 10463607.
• Tanaka S, Tsuda N, Kawano K, Sakamoto M, Nishida T, Hashimoto T, Shichijo S, Kamura T, Itoh K (November 2000). "Expression of tumor-rejection antigens in gynecologic cancers". Japanese Journal of Cancer Research. 91 (11): 1177–84. doi:10.1111/j.1349-7006.2000.tb00902.x. PMC 5926290. PMID 11092984.
• Harada K, Yamada A, Yang D, Itoh K, Shichijo S (September 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". International Journal of Cancer. 93 (5): 623–8. doi:10.1002/ijc.1391. PMID 11477570. S2CID 24724555.
• Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (March 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer. 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522. S2CID 33045822.
• Liu Y, Li J, Kim BO, Pace BS, He JJ (June 2002). "HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110". The Journal of Biological Chemistry. 277 (26): 23854–63. doi:10.1074/jbc.M200773200. PMID 11959860.
• Bell M, Schreiner S, Damianov A, Reddy R, Bindereif A (June 2002). "p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor". The EMBO Journal. 21 (11): 2724–35. doi:10.1093/emboj/21.11.2724. PMC 126028. PMID 12032085.
• Nottrott S, Urlaub H, Lührmann R (October 2002). "Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins". The EMBO Journal. 21 (20): 5527–38. doi:10.1093/emboj/cdf544. PMC 129076. PMID 12374753.
• Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Stanĕk D, Rader SD, Klingauf M, Neugebauer KM (February 2003). "Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies". The Journal of Cell Biology. 160 (4): 505–16. doi:10.1083/jcb.200210087. PMC 2173746. PMID 12578909.
• Damianov A, Schreiner S, Bindereif A (February 2004). "Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP". Molecular and Cellular Biology. 24 (4): 1700–8. doi:10.1128/MCB.24.4.1700-1708.2004. PMC 344176. PMID 14749385.
• Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ (May 2004). "Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation". The Journal of Biological Chemistry. 279 (21): 21766–73. doi:10.1074/jbc.M314321200. PMID 15031286.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Medenbach J, Schreiner S, Liu S, Lührmann R, Bindereif A (September 2004). "Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling". Molecular and Cellular Biology. 24 (17): 7392–401. doi:10.1128/MCB.24.17.7392-7401.2004. PMC 506986. PMID 15314151.
• Stanĕk D, Neugebauer KM (September 2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer". The Journal of Cell Biology. 166 (7): 1015–25. doi:10.1083/jcb.200405160. PMC 2172029. PMID 15452143.