Levels of estradiol at steady-state over a period of 4 days with different dosages of Vivelle-type (Vivelle, Vivelle-Dot, Mylan generic) twice-weekly transdermal estradiol matrix patches applied to the abdomen and worn until day 4 in postmenopausal women.[1][2][3]
Levels of estradiol over a period of 7.5 days after a single application of different dosages of a Climara-type (Climara, Menostar, Mylan generic) once-weekly transdermal estradiol matrix patch to the abdomen and removed on day 7 in postmenopausal women.[4][5][6]
Levels of estradiol over a period of 8 days after a single application of a 50 or 100 μg/day Climara-type (Climara, Menostar, Mylan generic) once-weekly transdermal estradiol matrix patch to the abdomen and removed on day 7 in postmenopausal women.[7]
Levels of estradiol and estrone with application of a single 50 µg/day estradiol transdermal reservoir patch (Estraderm) in postmenopausal women.[8]
Estradiol level with a single 100 µg/day estradiol reservoir patch (Estraderm) with and without ethanol added in postmenopausal women.[9][10] This patch has a 3- to 4-day duration and is designed for twice-weekly application. In one group, ethanol was injected into the area between the patch and the skin on day 3.[9][10] This gave significantly higher and prolonged estradiol levels.[9][10]
Estradiol and testosterone levels with high-dosage transdermal estradiol in the form of two to six 100 µg/day estradiol patches (Progynova TS forte) in men with prostate cancer.[11][12][13]
Estradiol levels with 50 to 100 μg/day transdermal estradiol patches applied to the forearm and to the scrotum in a crossover study in 2 men with prostate cancer.[14] In 35 men treated continuously with one 100 μg/day estradiol patch scrotally, the mean estradiol level was ~500 pg/mL (range ~125–1,200 pg/mL).[14]
^ abcSmith RD, Robinson DE, Delignieres B, Albertson BD, Tomai TP, Zinaman MJ, Simon JA (December 1991). "Effects of vehicle supplementation on total estradiol absorption from a transdermal estradiol delivery system". Fertil. Steril. 56 (6): 1029–33. doi:10.1016/S0015-0282(16)54712-8. PMID1743317.
^Ockrim JL, Lalani EN, Laniado ME, Carter SS, Abel PD (May 2003). "Transdermal estradiol therapy for advanced prostate cancer--forward to the past?". J. Urol. 169 (5): 1735–7. doi:10.1097/01.ju.0000061024.75334.40. PMID12686820.
^Ockrim J, Lalani EN, Abel P (October 2006). "Therapy Insight: parenteral estrogen treatment for prostate cancer--a new dawn for an old therapy". Nat Clin Pract Oncol. 3 (10): 552–63. doi:10.1038/ncponc0602. PMID17019433. S2CID6847203.
![Levels of estradiol at steady-state over a period of 4 days with different dosages of Vivelle-type (Vivelle, Vivelle-Dot, Mylan generic) twice-weekly transdermal estradiol matrix patches applied to the abdomen and worn until day 4 in postmenopausal women.[1][2][3]](https://upload.wikimedia.org/wikipedia/commons/thumb/d/d9/Estradiol_levels_with_different_dosages_of_transdermal_estradiol_patches_%28Vivelle-type%29_in_postmenopausal_women.png/300px-Estradiol_levels_with_different_dosages_of_transdermal_estradiol_patches_%28Vivelle-type%29_in_postmenopausal_women.png)
![Levels of estradiol over a period of 7.5 days after a single application of different dosages of a Climara-type (Climara, Menostar, Mylan generic) once-weekly transdermal estradiol matrix patch to the abdomen and removed on day 7 in postmenopausal women.[4][5][6]](https://upload.wikimedia.org/wikipedia/commons/thumb/4/43/Estradiol_levels_with_different_dosages_of_transdermal_estradiol_patches_%28Climara-type%29_in_postmenopausal_women.png/300px-Estradiol_levels_with_different_dosages_of_transdermal_estradiol_patches_%28Climara-type%29_in_postmenopausal_women.png)
![Levels of estradiol over a period of 8 days after a single application of a 50 or 100 μg/day Climara-type (Climara, Menostar, Mylan generic) once-weekly transdermal estradiol matrix patch to the abdomen and removed on day 7 in postmenopausal women.[7]](https://upload.wikimedia.org/wikipedia/commons/thumb/c/c1/Estradiol_levels_with_a_50_or_100_%CE%BCg_per_day_transdermal_estradiol_patch_%28Climara-type%29_in_women.png/271px-Estradiol_levels_with_a_50_or_100_%CE%BCg_per_day_transdermal_estradiol_patch_%28Climara-type%29_in_women.png)
Levels of estradiol over a period of 8 days after a single application of a 50 or 100![Levels of estradiol and estrone with application of a single 50 µg/day estradiol transdermal reservoir patch (Estraderm) in postmenopausal women.[8]](https://upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Estrogen_levels_with_a_50_%C2%B5g_per_day_estradiol_transdermal_patch_in_postmenopausal_women.png/300px-Estrogen_levels_with_a_50_%C2%B5g_per_day_estradiol_transdermal_patch_in_postmenopausal_women.png)
Levels of estradiol and estrone with application of a single 50 µg/day estradiol transdermal reservoir patch (Estraderm) in postmenopausal women.[8]![Estradiol level with a single 100 µg/day estradiol reservoir patch (Estraderm) with and without ethanol added in postmenopausal women.[9][10] This patch has a 3- to 4-day duration and is designed for twice-weekly application. In one group, ethanol was injected into the area between the patch and the skin on day 3.[9][10] This gave significantly higher and prolonged estradiol levels.[9][10]](https://upload.wikimedia.org/wikipedia/commons/thumb/e/e1/Estradiol_levels_with_a_single_application_of_a_100_%C2%B5g_per_day_estradiol_reservoir_patch_%28Estraderm%29_with_and_without_an_ethanol_injection_in_postmenopausal_women.png/299px-thumbnail.png)
Estradiol level with a single 100 µg/day estradiol reservoir patch (Estraderm) with and without ethanol added in postmenopausal women.[9][10] This patch has a 3- to 4-day duration and is designed for twice-weekly application. In one group, ethanol was injected into the area between the patch and the skin on day 3.[9][10] This gave significantly higher and prolonged estradiol levels.[9][10]![Estradiol and testosterone levels with high-dosage transdermal estradiol in the form of two to six 100 µg/day estradiol patches (Progynova TS forte) in men with prostate cancer.[11][12][13]](https://upload.wikimedia.org/wikipedia/commons/thumb/a/ab/Estradiol_and_testosterone_levels_with_high-dose_estradiol_patches_in_men.png/300px-Estradiol_and_testosterone_levels_with_high-dose_estradiol_patches_in_men.png)
![Estradiol levels with 50 to 100 μg/day transdermal estradiol patches applied to the forearm and to the scrotum in a crossover study in 2 men with prostate cancer.[14] In 35 men treated continuously with one 100 μg/day estradiol patch scrotally, the mean estradiol level was ~500 pg/mL (range ~125–1,200 pg/mL).[14]](https://upload.wikimedia.org/wikipedia/commons/thumb/e/e9/Estradiol_levels_with_transdermal_estradiol_patches_applied_to_the_forearm_or_scrotum_in_men.png/300px-Estradiol_levels_with_transdermal_estradiol_patches_applied_to_the_forearm_or_scrotum_in_men.png)
Estradiol levels with 50 to 100![Levels of estradiol at steady-state over a period of 4 days with different dosages of Vivelle-type (Vivelle, Vivelle-Dot, Mylan generic) twice-weekly transdermal estradiol matrix patches applied to the abdomen and worn until day 4 in postmenopausal women.[1][2][3]](https://trans.hiragana.jp/ruby/https://en.wikipedia.org/wiki/File:Estradiol_levels_with_different_dosages_of_transdermal_estradiol_patches_(Vivelle-type)_in_postmenopausal_women.png)
![Levels of estradiol over a period of 7.5 days after a single application of different dosages of a Climara-type (Climara, Menostar, Mylan generic) once-weekly transdermal estradiol matrix patch to the abdomen and removed on day 7 in postmenopausal women.[4][5][6]](https://trans.hiragana.jp/ruby/https://en.wikipedia.org/wiki/File:Estradiol_levels_with_different_dosages_of_transdermal_estradiol_patches_(Climara-type)_in_postmenopausal_women.png)
![Levels of estradiol over a period of 8 days after a single application of a 50 or 100 μg/day Climara-type (Climara, Menostar, Mylan generic) once-weekly transdermal estradiol matrix patch to the abdomen and removed on day 7 in postmenopausal women.[7]](https://trans.hiragana.jp/ruby/https://en.wikipedia.org/wiki/File:Estradiol_levels_with_a_50_or_100_%CE%BCg_per_day_transdermal_estradiol_patch_(Climara-type)_in_women.png)
![Levels of estradiol and estrone with application of a single 50 µg/day estradiol transdermal reservoir patch (Estraderm) in postmenopausal women.[8]](https://trans.hiragana.jp/ruby/https://en.wikipedia.org/wiki/File:Estrogen_levels_with_a_50_%C2%B5g_per_day_estradiol_transdermal_patch_in_postmenopausal_women.png)
![Estradiol level with a single 100 µg/day estradiol reservoir patch (Estraderm) with and without ethanol added in postmenopausal women.[9][10] This patch has a 3- to 4-day duration and is designed for twice-weekly application. In one group, ethanol was injected into the area between the patch and the skin on day 3.[9][10] This gave significantly higher and prolonged estradiol levels.[9][10]](https://trans.hiragana.jp/ruby/https://en.wikipedia.org/wiki/File:Estradiol_levels_with_a_single_application_of_a_100_%C2%B5g_per_day_estradiol_reservoir_patch_(Estraderm)_with_and_without_an_ethanol_injection_in_postmenopausal_women.png)
![Estradiol and testosterone levels with high-dosage transdermal estradiol in the form of two to six 100 µg/day estradiol patches (Progynova TS forte) in men with prostate cancer.[11][12][13]](https://trans.hiragana.jp/ruby/https://en.wikipedia.org/wiki/File:Estradiol_and_testosterone_levels_with_high-dose_estradiol_patches_in_men.png)
![Estradiol levels with 50 to 100 μg/day transdermal estradiol patches applied to the forearm and to the scrotum in a crossover study in 2 men with prostate cancer.[14] In 35 men treated continuously with one 100 μg/day estradiol patch scrotally, the mean estradiol level was ~500 pg/mL (range ~125–1,200 pg/mL).[14]](https://trans.hiragana.jp/ruby/https://en.wikipedia.org/wiki/File:Estradiol_levels_with_transdermal_estradiol_patches_applied_to_the_forearm_or_scrotum_in_men.png)
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