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Protein-coding gene in the species Homo sapiens
Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene .[ 5] [ 6]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes : ubiquitin-activating enzymes , or E1s, ubiquitin-conjugating enzymes , or E2s, and ubiquitin-protein ligases , or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000182179 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032596 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B (Aug 1993). "A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme" . Proc Natl Acad Sci U S A . 90 (13): 6071–5. Bibcode :1993PNAS...90.6071K . doi :10.1073/pnas.90.13.6071 PMC 46869 PMID 8327486 . ^ a b "Entrez Gene: UBE1L ubiquitin-activating enzyme E1-like" .
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