WNT9B

WNT9B
Identifiers
Aliases	WNT9B, WNT14B, WNT15, Wnt family member 9B
External IDs	OMIM: 602864; MGI: 1197020; HomoloGene: 2551; GeneCards: WNT9B; OMA:WNT9B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	46,886,730 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	103,640,647 bp
RNA expression pattern
	Top expressed in
	gonad; ; duodenum; ; human kidney; ; prefrontal cortex; ; placenta; ; apex of heart; ; superior frontal gyrus; ; primary visual cortex; ; right frontal lobe; ; right auricle;
	Top expressed in
	interventricular septum; ; medullary collecting duct; ; cortical collecting duct; ; surface ectoderm; ; labioscrotal swelling; ; semi-lunar valve; ; cloacal membrane; ; lateral geniculate nucleus; ; maxillary prominence; ; mandibular prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	frizzled binding; signaling receptor binding; co-receptor binding; receptor ligand activity;
Cellular component	extracellular region; extracellular space;
Biological process	kidney morphogenesis; cell-cell signaling; cellular response to starvation; mesonephric duct formation; multicellular organism development; male genitalia development; cornea development in camera-type eye; branching morphogenesis of an epithelial tube; kidney rudiment formation; collecting duct development; regulation of asymmetric cell division; embryonic cranial skeleton morphogenesis; kidney development; Wnt signaling pathway, planar cell polarity pathway; cellular response to retinoic acid; mesenchymal stem cell maintenance involved in nephron morphogenesis; establishment of planar polarity involved in nephron morphogenesis; nephron tubule morphogenesis; roof of mouth development; metanephric tubule development; in utero embryonic development; regulation of tube size; mesonephric tubule development; uterus morphogenesis; response to retinoic acid; regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; cell fate commitment; branching involved in ureteric bud morphogenesis; positive regulation of catalytic activity; metanephric tubule formation; regulation of protein phosphorylation; negative regulation of stem cell population maintenance; midbrain dopaminergic neuron differentiation; non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; Wnt signaling pathway; neuron differentiation; regulation of signaling receptor activity; canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7484
	22412
	ENSG00000158955; ENSG00000276799
	ENSMUSG00000018486
	O14905
	O35468
	NM_003396; NM_001320458
	NM_011719
	NP_001307387; NP_003387
	NP_035849
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Wnt-9b (formerly Wnt15^[5]) is a protein that in humans is encoded by the WNT9B gene.^[6]

The Wnt family of genes produce glycolipoproteins that are involved with signaling and developmental processes. Like other Wnt genes, Wnt-9b codes for the Wnt-9b protein which participates in the canonical Wnt/βべーた-catenin signaling pathway. Wnt-9b is a gene found on chromosome 17 in region 17q21. It can be traced to function in the establishment of the kidneys, because Wnt9 is critical for morphogenesis of the nephron.^[7] This gene can impact kidney function in more than one way. Improper expression of the gene can cause cyst development on the kidney tubules, and in mice, mutant Wnt9 genes that cause lower protein concentrations resulted in failure of the kidneys to thrive shortly after birth.^[8] Wnt-9b is a gene that often expressed in the epithelial cells of the Wolfian duct in early male and female embryos. In the embryos, Wnt11 is expressed at the branching points of the kidney tubules while Wnt-9b is expressed in a higher concentration at the stalk of the tubules.^[9] Wnt-9b has also been tied to the involvement of neural differentiation by induction of retinoic acid, according to the NCBI.^[10]

References

^ ^a ^b ^c ENSG00000276799 GRCh38: Ensembl release 89: ENSG00000158955, ENSG00000276799 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018486 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Garriock RJ, Warkman AS, Meadows SM, D'Agostino S, Krieg PA (2007). "Census of vertebrate Wnt genes: isolation and developmental expression of Xenopus Wnt2, Wnt3, Wnt9a, Wnt9b, Wnt10a, and Wnt16". Developmental Dynamics. 236 (5): 1249–58. doi:10.1002/dvdy.21156. PMID 17436276. S2CID 21016668.
^ "Entrez Gene: Wnt9b wingless-type MMTV integration site family, member 9B".
^ Karner C, Chirumamilla R, Aoki S, et al. (2009). "Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis". Nat Genet. 41 (7): 793–799. doi:10.1038/ng.400. PMC 2761080. PMID 19543268.
^ Karner C, Chirumamilla R, Aoki S, et al. (2009). "Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis". Nat Genet. 41 (7): 793–799. doi:10.1038/ng.400. PMC 2761080. PMID 19543268.
^ Carroll T, Park J, Hayashi S, Majumdar A, McMahon A, et al. (2005). "Wnt9b Plays a Central Role in the Regulation of Mesenchymal to Epithelial Transitions Underlying Organogenesis of the Mammalian Urogenital System". Developmental Cell. 9 (2): 283–292. doi:10.1016/j.devcel.2005.05.016. PMID 16054034.
^ "WNT9B Wnt family member 9B [Homo sapiens (human)]". NCBI Genes & Expression. 2021-04-06. Retrieved 2021-04-14.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000276799 GRCh38: Ensembl release 89: ENSG00000158955, ENSG00000276799 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018486 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Garriock RJ, Warkman AS, Meadows SM, D'Agostino S, Krieg PA (2007). "Census of vertebrate Wnt genes: isolation and developmental expression of Xenopus Wnt2, Wnt3, Wnt9a, Wnt9b, Wnt10a, and Wnt16". Developmental Dynamics. 236 (5): 1249–58. doi:10.1002/dvdy.21156. PMID 17436276. S2CID 21016668.

[entrez-6] "Entrez Gene: Wnt9b wingless-type MMTV integration site family, member 9B".

[7] Karner C, Chirumamilla R, Aoki S, et al. (2009). "Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis". Nat Genet. 41 (7): 793–799. doi:10.1038/ng.400. PMC 2761080. PMID 19543268.

[8] Karner C, Chirumamilla R, Aoki S, et al. (2009). "Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis". Nat Genet. 41 (7): 793–799. doi:10.1038/ng.400. PMC 2761080. PMID 19543268.

[9] Carroll T, Park J, Hayashi S, Majumdar A, McMahon A, et al. (2005). "Wnt9b Plays a Central Role in the Regulation of Mesenchymal to Epithelial Transitions Underlying Organogenesis of the Mammalian Urogenital System". Developmental Cell. 9 (2): 283–292. doi:10.1016/j.devcel.2005.05.016. PMID 16054034.

[10] "WNT9B Wnt family member 9B [Homo sapiens (human)]". NCBI Genes & Expression. 2021-04-06. Retrieved 2021-04-14.

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v t e Signaling pathway: Wnt signaling pathway
Ligand	WNT1 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B WNT10A WNT10B WNT11 WNT16
Receptor	Frizzled LRP5 LRP6
Second messenger	Dishevelled GSK-3 APC Beta-catenin