eEF2K
eEF2K（eukaryotic elongation factor 2 kinase）は、ヒトではEEF2K
機能
[eEF2Kはカルモジュリンを
活性 化
[eEF2Kの
eEF2KはSer500の
臨床 的 意義
[eEF2Kの
eEF2Kは、
がん
[eEF2Kの
出典
[- ^ a b c GRCh38: Ensembl release 89: ENSG00000103319、ENSG00000284161 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035064 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ a b c “Entrez Gene: EEF2K eukaryotic elongation factor-2 kinase”. 2022
年 1月 15日 閲覧 。 - ^ “Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase”. Proceedings of the National Academy of Sciences of the United States of America 94 (10): 4884–9. (May 1997). Bibcode: 1997PNAS...94.4884R. doi:10.1073/pnas.94.10.4884. PMC 24600. PMID 9144159.
- ^ “EEF2K Gene (Protein Coding)”. GeneCards. Weizmann Institute of Science. 4 November 2015
閲覧 。 - ^ “Phosphorylation of elongation factor 2: a key mechanism regulating gene expression in vertebrates”. The New Biologist 2 (10): 843–50. (Oct 1990). PMID 1964087.
- ^ a b “Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence”. Biochemistry 51 (11): 2232–45. (Mar 2012). doi:10.1021/bi201788e. PMC 3401519. PMID 22329831.
- ^ a b “The molecular mechanism of eukaryotic elongation factor 2 kinase activation”. The Journal of Biological Chemistry 289 (34): 23901–16. (Aug 2014). doi:10.1074/jbc.m114.577148. PMC 4156036. PMID 25012662.
- ^ “The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation”. Cell 153 (5): 1064–79. (May 2013). doi:10.1016/j.cell.2013.04.055. PMC 4395874. PMID 23706743.
- ^ “The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine”. Biological Psychiatry 73 (12): 1199–203. (Jun 2013). doi:10.1016/j.biopsych.2012.09.006. PMC 3574622. PMID 23062356.
- ^ “Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer.”. PLOS ONE 7 (7): e41171. (Mar 20, 2012). Bibcode: 2012PLoSO...741171T. doi:10.1371/journal.pone.0041171. PMC 3401164. PMID 22911754.
- ^ “Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells.”. Apoptosis 19 (1): 241–58. (Jan 22, 2014). doi:10.1007/s10495-013-0927-2. PMID 24193916.
関連 文献
[- “Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2”. The Journal of Biological Chemistry 262 (36): 17299–303. (Dec 1987). doi:10.1016/S0021-9258(18)45377-X. PMID 3693353.
- “Regulation of elongation factor-2 by multisite phosphorylation”. European Journal of Biochemistry 213 (2): 689–99. (Apr 1993). doi:10.1111/j.1432-1033.1993.tb17809.x. PMID 8386634.
- “Mapping the functional domains of elongation factor-2 kinase”. Biochemistry 39 (40): 12216–24. (Oct 2000). doi:10.1021/bi0007270. PMID 11015200.
- “Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity”. The Biochemical Journal 353 (Pt 3): 621–6. (Feb 2001). doi:10.1042/0264-6021:3530621. PMC 1221608. PMID 11171059.
- “A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta”. The EMBO Journal 20 (16): 4360–9. (Aug 2001). doi:10.1093/emboj/20.16.4360. PMC 125581. PMID 11500363.
- “Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase”. The EMBO Journal 20 (16): 4370–9. (Aug 2001). doi:10.1093/emboj/20.16.4370. PMC 125559. PMID 11500364.
- “Detection of anti-elongation factor 2 kinase (calmodulin-dependent protein kinase III) antibodies in patients with systemic lupus erythematosus”. Biochemical and Biophysical Research Communications 293 (3): 1073–6. (May 2002). doi:10.1016/S0006-291X(02)00324-8. PMID 12051769.
- “Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants”. Molecular Vision 8: 205–20. (Jun 2002). PMID 12107410.
- “Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways”. The Biochemical Journal 367 (Pt 2): 525–32. (Oct 2002). doi:10.1042/BJ20020916. PMC 1222910. PMID 12171600.
- “Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398”. The Journal of Biological Chemistry 279 (13): 12220–31. (Mar 2004). doi:10.1074/jbc.M309773200. PMID 14709557.
- “A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin”. Molecular and Cellular Biology 24 (7): 2986–97. (Apr 2004). doi:10.1128/MCB.24.7.2986-2997.2004. PMC 371112. PMID 15024086.
- “Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry”. Analytical Chemistry 76 (10): 2763–72. (May 2004). doi:10.1021/ac035352d. PMID 15144186.
- “Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain”. The FEBS Journal 272 (16): 4211–20. (Aug 2005). doi:10.1111/j.1742-4658.2005.04833.x. PMID 16098202.
- “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Research 16 (1): 55–65. (Jan 2006). doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- “Elongation factor-2 kinase: its role in protein synthesis and autophagy”. Autophagy 2 (4): 294–6. (2007). doi:10.4161/auto.2857. PMID 16921268.
- “A probability-based approach for high-throughput protein phosphorylation analysis and site localization”. Nature Biotechnology 24 (10): 1285–92. (Oct 2006). doi:10.1038/nbt1240. PMID 16964243.
- “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell 127 (3): 635–48. (Nov 2006). doi:10.1016/j.cell.2006.09.026. PMID 17081983.