There is great interest in understanding the physics of magnetic ordering and electronic transport in materials of reduced dimensionality with strong spin-orbit coupling. This paper presents magnetotransport measurements of FeTaS single crystals, which are found to exhibit very large magnetoresistance (MR) for magnetic fields along the easy axis. The authors believe that such a large MR arises from spin disorder scattering and propose to use this mechanism as a design principle for materials with large MR. Further tests are needed to fully rule out contributions from a more conventional anisotropic MR mechanism.