Itrakonazola
Penampilan
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Data klinikal | |
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Nama dagang | Sporanox, Sporaz, Orungal, lain-lain |
Nama lain | ITZ |
AHFS/Drugs.com | Monograph |
MedlinePlus | a692049 |
Data lesen |
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Kategori kehamilan |
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Kaedah pemberian | Mulut (kapsul, larutan), setempat (faraj), intravena (IV) |
Kod ATC | |
Status perundangan | |
Status perundangan | |
Data farmakokinetik | |
Bioketersediaan | ~55%, maksimum jika dengan makan |
Pengikatan protein | 99.8% |
Metabolisme | Meluas di hati (CYP3A4) |
Metabolit | Hidroksiitrakonazola, ketoitrakonazola, N-desalkilitrakonazola[3] |
Penyingkiran separuh hayat | 21 jam |
Perkumuhan | Air kencing (35%), tahi (54%)[4] |
Pengecam | |
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Nombor CAS | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.123.596 |
Data kimia dan fizikal | |
Formula | C35H38Cl2N8O4 |
Jisim molar | 705.64 |
Model 3D (JSmol) | |
Kekiralan | Campuran rasem |
Takat lebur | 165[5] °C (329 °F) |
Keterlarutan dalam air | 7.8 ± 0.4 × 10−6 mol/L (pH 1.6)[5] mg/mL (20 °C) |
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Itrakonazol (R51211), dicipta pada 1984, ialah agen antikulat triazola dipreskripsi kepada pesakit dengan jangkitan kulat. Ubat ini boleh diberikan melalui mulut atau melalui intravena.
Lihat juga
[sunting | sunting sumber]Rujukan
[sunting | sunting sumber]- ^ a b "Itraconazole Use During Pregnancy". Drugs.com. 20 March 2019. Dicapai pada 15 May 2020.
- ^ "Sporanox 10 mg/mL Oral Solution - Summary of Product Characteristics (SmPC)". (emc). 1 February 2018. Dicapai pada 15 May 2020.
- ^ Isoherranen N, Kunze KL, Allen KE, Nelson WL, Thummel KE (October 2004). "Role of itraconazole metabolites in CYP3A4 inhibition". Drug Metabolism and Disposition. 32 (10): 1121–1131. doi:10.1124/dmd.104.000315. PMID 15242978. S2CID 6941636.
- ^ "Sporanox (itraconazole) Capsules. Full Prescribing Information" (PDF). Janssen Pharmaceuticals, Inc. Diarkibkan daripada yang asal (PDF) pada 17 May 2018. Dicapai pada 28 August 2016.
- ^ a b Vasilev NA, Surov AO, Voronin AP, Drozd KV, Perlovich GL (April 2021). "Novel cocrystals of itraconazole: Insights from phase diagrams, formation thermodynamics and solubility". International Journal of Pharmaceutics. 599: 120441. doi:10.1016/j.ijpharm.2021.120441. PMID 33675927. S2CID 232135660.
Pautan luar
[sunting | sunting sumber]- Maklumat farmokologi umum tentang itrakonazol, Institut Kesihatan Negara
- Laluan Mulut Itrakonazol, Mayo Clinic
Kategori:
- Template:drugs.com link with non-standard subpage
- Drugs with non-standard legal status
- ECHA InfoCard ID from Wikidata
- Drugboxes which contain changes to watched fields
- Antikulat triazola
- Triazola
- Piperazina
- Kloroarena
- Dioksolana
- Laktam
- Janssen Pharmaceutica
- Reka cipta Belgium
- Jenama Johnson & Johnson
- Eter feniletanolamina
- Perencat CYP3A4
- Para-Metoksifenilpiperazina