Brian Kent Kobilka
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Brian Kent Kobilka (* 30. Mai 1955 in Little Falls, Minnesota) is en US-amerikaansch Biochemiker. De Perfesser vun de Stanford University School of Medicine kreeg 2012 gemeensam mit Robert Joseph Lefkowitz den Nobelpries för Chemie „för hör Studien to G-Protein-koppelt Rezeptoren“.
Leven un wetenschaplich Wark
[ännern | Bornkood ännern]De Vader un Grootvader vun Kobilka weern Backer vun Berop. Kobilka studeer Biologie un Chemie an de University of Minnesota Duluth un hett nah sien Bachelor de School of Medicine vun de Yale University besöcht. Nah en internistisch Wiederbillen an dat Barnes Hospital vun de Washington University in St. Louis forsch he as Postdoc bi Robert Lefkowitz an de Duke University. Sien besünner oogenamrk gull sietdem den
Sien Ehefru Tong Sun Thian hett he an de Universität vun Minnesota kennen lehrt. Se hebbt twee Kinner.[8]
Publikatschoonen (Utwahl)
[ännern | Bornkood ännern]- Brian K. Kobilka et al.: An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. In: Nature, Band 329, Nr. 6134, 1987, S. 75–79, doi:10.1038/329075a0.
- Daniel K. Rohrer, Brian K. Kobilka: G protein-coupled receptors: functional and mechanistic insights through altered gene expression. In: Physiological Reviews, Band 78, Nr. 1, 1998, S. 35–52, PMID 9457168.
- Brian K. Kobilka: G protein coupled receptor structure and activation. In: Biochimica et Biophysica Acta, Band 1768, Nr. 4, 2007, S. 794–807, doi:10.1016/j.bbamem.2006.10.021.
- Jan Steyaert, Brian K. Kobilka: Nanobody stabilization of G protein-coupled receptor conformational states. In: Current Opinion in Structural Biology, Band 21, Nr. 4, 2011, S. 567–572, doi:10.1016/j.sbi.2011.06.011.
Literatur
[ännern | Bornkood ännern]Weblenken
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- [* Kobilka up de Siet vun den Nobelspries (engelsch)
- stanford.edu Websteed vun de Arbeitsgrupp Kobilka
Enkeld Nahwiesen
[ännern | Bornkood ännern]- ↑ Richard A. F. Dixon, Brian K. Kobilka et al.: Cloning of the gene and cDNA for mammalian
β -adrenergic receptor and homology with rhodopsin. In: Nature, Band 321, Nr. 6065, 1986, S. 75–79, doi:10.1038/321075a0, PMID 3010132. - ↑ Wadim Tscheresow, Daniel M. Rosenbaum et al.: High-Resolution Crystal Structure of an Engineered Human
β 2-Adrenergic G Protein–Coupled Receptor. In: Science, Band 318, Nr. 5854, 2007, S. 1258–1265, doi:10.1126/science.1150577, PMID 17962520. - ↑ Daniel M. Rosenbaum, Wadim Tscheresow et al.: GPCR Engineering Yields High-Resolution Structural Insights into
β -Adrenergic Receptor Function. In: Science Band 318, Nr. 5854, 2007, S. 1266–1273, doi:10.1126/science.1150609, PMID 17962519. - ↑ Søren G. F. Rasmussen, Choi Hee-jung et al.: Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. In: Nature, Band 450, Nr. 7168, 2007, S. 383–387, doi:10.1038/nature06325, PMID 17952055.
- ↑ Michael P. Bokoch, Zou Yaozhong et al.: Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. In: Nature, Band 463, Nr. 7277, 2010, S. 108–112, doi:10.1038/nature08650, PMID 20054398.
- ↑ Chung Ka Young, Søren G. F. Rasmussen et al.: Conformational changes in the G protein Gs induced by the
β 2 adrenergic receptor. In: Nature, Band 477, Nr. 7366, 2011, S. 611–615, doi:10.1038/nature10488, PMID 21956331. - ↑ Websteed vun de American Society for Pharmacology and Experimental Therapeutics (Stand: 10. Oktober 2012)
- ↑ Lizzie Buchen: Cell signalling: It’s all about the structure. In: Nature, Band 476, Nr. 7361, 2011, S. 387–390, doi:10.1038/476387a.