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Page 1
Molecular aspects of fructose metabolism and metabolic disease.
Herman MA, Birnbaum MJ. Herman MA, et al. Cell Metab. 2021 Dec 7;33(12):2329-2354. doi: 10.1016/j.cmet.2021.09.010. Epub 2021 Oct 6. Cell Metab. 2021. PMID: 34619074 Free PMC article. Review.
The unique aspects of fructose metabolism and properties of fructose-derived metabolites allow for fructose to serve as a physiological signal of normal dietary sugar consumption. ...Here, we review the biochemistry, genetics, and physiology of fructose …
The unique aspects of fructose metabolism and properties of fructose-derived metabolites allow for fructose to serve as …
Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.
Jensen T, Abdelmalek MF, Sullivan S, Nadeau KJ, Green M, Roncal C, Nakagawa T, Kuwabara M, Sato Y, Kang DH, Tolan DR, Sanchez-Lozada LG, Rosen HR, Lanaspa MA, Diehl AM, Johnson RJ. Jensen T, et al. J Hepatol. 2018 May;68(5):1063-1075. doi: 10.1016/j.jhep.2018.01.019. Epub 2018 Feb 2. J Hepatol. 2018. PMID: 29408694 Free PMC article. Review.
Herein, we review the experimental and clinical evidence that fructose precipitates fat accumulation in the liver, due to both increased lipogenesis and impaired fat oxidation. Recent evidence suggests that the predisposition to fatty liver is linked to the metabolism of …
Herein, we review the experimental and clinical evidence that fructose precipitates fat accumulation in the liver, due to both increa …
Fructose and the Liver.
Muriel P, López-Sánchez P, Ramos-Tovar E. Muriel P, et al. Int J Mol Sci. 2021 Jun 28;22(13):6969. doi: 10.3390/ijms22136969. Int J Mol Sci. 2021. PMID: 34203484 Free PMC article. Review.
Metabolic syndrome is a constellation of disturbances affecting several organs, and it has been proposed to be a liver-centered condition. Fructose overconsumption may result in insulin resistance, oxidative stress, inflammation, elevated uric acid levels, increased …
Metabolic syndrome is a constellation of disturbances affecting several organs, and it has been proposed to be a liver-centered condition. …
Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?
Johnson RJ, Tolan DR, Bredesen D, Nagel M, Sánchez-Lozada LG, Fini M, Burtis S, Lanaspa MA, Perlmutter D. Johnson RJ, et al. Am J Clin Nutr. 2023 Mar;117(3):455-466. doi: 10.1016/j.ajcnut.2023.01.002. Epub 2023 Jan 11. Am J Clin Nutr. 2023. PMID: 36774227 Free PMC article. Review.
Here, we describe a recently discovered response that favors survival in times of scarcity, and it is initiated by either ingestion or production of fructose. Unlike glucose, which is a source for immediate energy needs, fructose metabolism results in an orchestrate …
Here, we describe a recently discovered response that favors survival in times of scarcity, and it is initiated by either ingestion or produ …
Fructose and uric acid in diabetic nephropathy.
Bjornstad P, Lanaspa MA, Ishimoto T, Kosugi T, Kume S, Jalal D, Maahs DM, Snell-Bergeon JK, Johnson RJ, Nakagawa T. Bjornstad P, et al. Diabetologia. 2015 Sep;58(9):1993-2002. doi: 10.1007/s00125-015-3650-4. Epub 2015 Jun 7. Diabetologia. 2015. PMID: 26049401 Free PMC article. Review.
For this reason, uric acid derived from endogenous fructose could cause tubulointerstitial injury in diabetes. ...In this review we discuss the relationship between uric acid and fructose as a novel mechanism for the development of diabetic tubular inj …
For this reason, uric acid derived from endogenous fructose could cause tubulointerstitial injury in diabetes. ...In this revi …
Sugar, uric acid, and the etiology of diabetes and obesity.
Johnson RJ, Nakagawa T, Sanchez-Lozada LG, Shafiu M, Sundaram S, Le M, Ishimoto T, Sautin YY, Lanaspa MA. Johnson RJ, et al. Diabetes. 2013 Oct;62(10):3307-15. doi: 10.2337/db12-1814. Diabetes. 2013. PMID: 24065788 Free PMC article. Review.
Fructose is a major component of added sugars and is distinct from other sugars in its ability to cause intracellular ATP depletion, nucleotide turnover, and the generation of uric acid. ...Recent studies show that fructose-induced uric acid generation …
Fructose is a major component of added sugars and is distinct from other sugars in its ability to cause intracellular ATP depletion, …
The fructose survival hypothesis for obesity.
Johnson RJ, Lanaspa MA, Sanchez-Lozada LG, Tolan D, Nakagawa T, Ishimoto T, Andres-Hernando A, Rodriguez-Iturbe B, Stenvinkel P. Johnson RJ, et al. Philos Trans R Soc Lond B Biol Sci. 2023 Sep 11;378(1885):20220230. doi: 10.1098/rstb.2022.0230. Epub 2023 Jul 24. Philos Trans R Soc Lond B Biol Sci. 2023. PMID: 37482773 Free PMC article. Review.
The response is characterized by hunger, thirst, foraging, weight gain, fat accumulation, insulin resistance, systemic inflammation and increased blood pressure. The process is initiated by the ingestion of fructose or by stimulating endogenous fructose production v …
The response is characterized by hunger, thirst, foraging, weight gain, fat accumulation, insulin resistance, systemic inflammation and incr …
Fructose Intake, Serum Uric Acid, and Cardiometabolic Disorders: A Critical Review.
Caliceti C, Calabria D, Roda A, Cicero AFG. Caliceti C, et al. Nutrients. 2017 Apr 18;9(4):395. doi: 10.3390/nu9040395. Nutrients. 2017. PMID: 28420204 Free PMC article. Review.
There is a direct relationship between fructose intake and serum levels of uric acid (UA), which is the final product of purine metabolism. ...Other dietary and pathophysiological factors are also related to UA production. However, the role of fructose-derive …
There is a direct relationship between fructose intake and serum levels of uric acid (UA), which is the final product of purin …
Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age.
Russo E, Leoncini G, Esposito P, Garibotto G, Pontremoli R, Viazzi F. Russo E, et al. Int J Mol Sci. 2020 Jun 24;21(12):4479. doi: 10.3390/ijms21124479. Int J Mol Sci. 2020. PMID: 32599713 Free PMC article. Review.
Recently, there has been a growing interest in epidemiological and clinical studies supporting a pathogenetic role of fructose in cardio-metabolic diseases, especially in children and adolescents. In the present review, we summarize experimental data on the potential biolo …
Recently, there has been a growing interest in epidemiological and clinical studies supporting a pathogenetic role of fructose in car …
Sirtuin deficiency and the adverse effects of fructose and uric acid synthesis.
Rodriguez-Iturbe B, Johnson RJ, Lanaspa MA, Nakagawa T, Garcia-Arroyo FE, Sánchez-Lozada LG. Rodriguez-Iturbe B, et al. Am J Physiol Regul Integr Comp Physiol. 2022 May 1;322(5):R347-R359. doi: 10.1152/ajpregu.00238.2021. Epub 2022 Mar 10. Am J Physiol Regul Integr Comp Physiol. 2022. PMID: 35271385 Free PMC article. Review.
Deficiency of sirtuin deacetylations is a consequence of reduced bioavailability of its cofactor nicotinamide adenine dinucleotide (NAD(+)). Uric acid-induced inflammation and oxidative stress consume NAD(+) and activation of the polyol pathway of fructose and ur …
Deficiency of sirtuin deacetylations is a consequence of reduced bioavailability of its cofactor nicotinamide adenine dinucleotide (NAD(+)). …
908 results