Elastaza
U molekularnoj biologiji, elastaza je enzim iz klase proteaza (peptidaza) koje razlažu proteine.[1]
Postoji osam ljudskih gena za elastaze:
| Familija | Simbol gena | Ime proteina | EC broj | ||
|---|---|---|---|---|---|
| Odobreno | Prethodno | Odobreno | Prethodno | ||
| himotripsinu- slična |
CELA1 | ELA1 | himotripsinu-slična familija elastaza, član 1 | elastaza 1, pankreasna | EC 3.4.21.36 |
| CELA2A | ELA2A | himotripsinu-slična familija elastaza, član 2A | elastaza 2A, pankreasna | EC 3.4.21.71 | |
| CELA2B | ELA2B | himotripsinu-slična familija elastaza, član 2B | elastaza 2B, pankreasna | EC 3.4.21.71 | |
| CELA3A | ELA3A | himotripsinu-slična familija elastaza, član 3A | elastaza 3A, pankreasna | EC 3.4.21.70 | |
| CELA3B | ELA3B | himotripsinu-slična familija elastaza, član 3B | elastaza 3B, pankreasna | EC 3.4.21.70 | |
| himotripsin | CTRC | ELA4 | himotripsin C (kaldekrin) | elastaza 4 | EC 3.4.21.2 |
| neutrofil | ELANE | ELA2 | neutrofilna elastaza | elastaza 2 | EC 3.4.21.37 |
| makrofag | MMP12 | HME | makrofagna metaloelastaza | makrofagna elastaza | EC 3.4.24.65 |
Bakterijske forme: Organizmi poput P. aeruginosa takođe formiraju elastate, i one se smatraju faktorom virulencije.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Pankreasna elastaza, enzim
- Leukocitna elastaza, enzim