Nabilon

Nabilon
(IUPAC) ime
	(6aR,10aR)-rel-1-hidroksi-6,6-dimetil-3-(2-metiloktan-2-il)-
Klinički podaci
AHFS/Drugs.com	Monografija
MedlinePlus	a607048
Identifikatori
CAS broj	51022-71-0
ATC kod	A04AD11
PubChem	5284592
DrugBank	DB00486
ChemSpider	4447641
UNII	2N4O9L084N
KEGG	D05099
ChEMBL	CHEMBL947
Hemijski podaci
Formula	C24H36O3
Mol. masa	372,541 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C24H36O3/c1-6-7-8-9-12-23(2,3)16-13-20(26)22-18-15-17(25)10-11-19(18)24(4,5)27-21(22)14-16/h13-14,18-19,26H,6-12,15H2,1-5H3/t18-,19-/m1/s1 ; Key: GECBBEABIDMGGL-RTBURBONSA-N
Farmakokinetički podaci
Bioraspoloživost	20% nakon prvog prolaza
Vezivanje za proteine plazme	slično sa THC (+/-97%)
Poluvreme eliminacije	2 sata, sa metabolitima oko 35 sati.
Farmakoinformacioni podaci
Trudnoća	C(US)
Pravni status	Droga (S8) (AUえーゆー) Schedule II (SAD)
Način primene	Oralna forma (PO) - kapsule

Nabilon je sintetički kanabinoid sa terapeutskom upotrebom kao antiemetik i kao pomoćni analgetik za neuropatski bol.^[6]^[7] On oponaša glavnu hemijsku komponentu kanabisa (THC), aktivni ingredijent prirodne Cannabis sativa L.^[8]

U Kanadi, SAD, UK i Meksiku, nabilon je u prodaji kao Cesamet. FDA je odobrila ovaj lek 1985. za tretman hemoterapijom uzrokovane mučnine i povraćanja na koje konvencionalni antiemetici nemaju dejstva. Mada je odobren 1985, lek je dospeo na američko tržište tek 2006. Ovaj lek je takođe odobren za lečenje anoreksije i gubitka telesne težine kod AIDS pacijenata.

Nabilon je racemska smeša koja se sastoji od (S,S) i (R,R) izomera ("trans").

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Skrabek RQ, Galimova L, Ethans K, Perry D (2008). „Nabilone for the treatment of pain in fibromyalgia”. J Pain 9 (2): 164–73. DOI:10.1016/j.jpain.2007.09.002. PMID 17974490.
↑ Wissel J, et al. (2006). „Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : a double-blind placebo-controlled cross-over trial”. J Neurol. 253 (10): 1337–41. DOI:10.1007/s00415-006-0218-8. PMID 16988792.
↑ „How to use Cesamet”. Artek LLC. 2008. Arhivirano iz originala na datum 2014-07-29. Pristupljeno 2014-04-05.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Šablon:Kanabinoidi

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[6] Skrabek RQ, Galimova L, Ethans K, Perry D (2008). „Nabilone for the treatment of pain in fibromyalgia”. J Pain 9 (2): 164–73. DOI:10.1016/j.jpain.2007.09.002. PMID 17974490.

[7] Wissel J, et al. (2006). „Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : a double-blind placebo-controlled cross-over trial”. J Neurol. 253 (10): 1337–41. DOI:10.1007/s00415-006-0218-8. PMID 16988792.

[How_to_use_Cesamet-8] „How to use Cesamet”. Artek LLC. 2008. Arhivirano iz originala na datum 2014-07-29. Pristupljeno 2014-04-05.

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