Orizin
| Orizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.63 | ||||||||
| CAS broj | 2620433 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Orizin (EC 3.4.21.63, Aspergillus alkaline proteinaza, aspergilopeptidaza B, API 21, aspergilopepsin B, aspergilopepsin F, Aspergillus candidus alkalna proteinaza, Aspergillus flavus alkalna proteinaza, Aspergillus melleus semialkalna proteinaza, Aspergillus oryzae alkalna proteinaza, Aspergillus parasiticus alkalna proteinaza, Aspergillus serin proteinaza, Aspergillus sydowi alkalna proteinaza, Aspergillus soya alkalna proteinaza, Aspergillus melleus alkalna proteinaza, Aspergillus sulphureus alkalna proteinaza, prozim, P 5380, kiorinaza, seaproza S, semi-alkalna proteaza, sumizim MP, prozim 10, onoproza, onoproza SA, proteaza P, promelaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina sa širokom specifičnošću, pri čemu je Bz-Arg-OEt > Ac-Tyr-Oet. Ne dolazi do hidrolize peptidnih amida
Ova peptidaza ne sadrži cistein.
- ↑ Nakagawa, Y. (1970). „Alkaline proteinases from Aspergillus”. Methods Enzymol. 19: 581-591.
- ↑ Hayashi, K. and Terada, M. (1972). „Some characteristics of hydrolysis of synthetic substrates and proteins by the alkaline proteases from Aspergillus sojae”. Agric. Biol. Chem. 36: 1755-1765.
- ↑ Turková, J., Mikes, O., Hayashi, K., Danno, G. and Polgár, L. (1972). „Alkaline proteinases of the genus Aspergillus”. Biochim. Biophys. Acta 257: 257-263. PMID 4623338.
- ↑ Morihara, K., Oka, T. and Tsuzuki, H. (1974). „Comparative study of various serine alkaline proteinases from microorganisms. Esterase activity against N-acylated peptide ester substrates”. Arch. Biochem. Biophys. 165: 72-79. PMID 4441086.
- ↑ Spadari, S., Subramanian, A.R. and Kalnitsky, G. (1974). „Highly restricted specificity of the serine proteinase aspergillopeptidase B”. Biochim. Biophys. Acta 359: 267-272. PMID 4859351.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.