Zofenopril
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(IUPAC) ime | |||
---|---|---|---|
(2S,4S)-1-((S)-3-(benzoiltio)-2-metilpropanoil)-4-(feniltio)pirolidin-2-karboksilna kiselina | |||
Klinički podaci | |||
AHFS/Drugs.com | Internacionalno ime leka | ||
Identifikatori | |||
CAS broj | 81872-10-8 | ||
ATC kod | C09AA15 | ||
PubChem[1][2] | 92400 | ||
ChemSpider[3] | 83422 | ||
UNII | 290ZY759PI ![]() | ||
KEGG[4] | D08688 ![]() | ||
ChEMBL[5] | CHEMBL331378 ![]() | ||
Hemijski podaci | |||
Formula | C22H23NO4S2 | ||
Mol. masa | 429,552 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | |||
Način primene | Oralno |
Zofenopril (Zofenoprilum) je inhbitor angiotenzin konvertujućeg enzima (ACE) sa kardioprotektivnim svojstvima, koji se koristi za tretman hipertenzije.[6]
U manjim kliničkim studijama je utvrđeno da je zofenopril znatno efektivniji od starijih antihipertenziva atenolola i enalaprila, i da uzrokuje manji broj nuspojava.[7][8]
Osobina | Vrednost |
---|---|
Broj akceptora vodonika | 6 |
Broj donora vodonika | 1 |
Broj rotacionih veza | 8 |
Particioni koeficijent[9] (ALogP) | 3,9 |
Rastvorljivost[10] (logS, log(mol/L)) | -5,8 |
Polarna površina[11] (PSA, Å2) | 125,3 |
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Ambrosioni E (2007). „Defining the role of zofenopril in the management of hypertension and ischemic heart disorders”. Am J Cardiovasc Drugs 7 (1): 17-24. DOI:10.2165/00129784-200707010-00002. PMID 17355163.
- ↑ Nilsson P (October 2007). „Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension”. Blood Press Suppl 2: 25-30. PMID 18046976.
- ↑ Mallion JM (October 2007). „An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension”. Blood Press Suppl 2: 13-8. PMID 18046974.
- ↑ Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o.
- ↑ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573.
- ↑ Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286.
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.