Извор странице 5-HT1B receptor

{{DISPLAYTITLE:5-HT<sub>1B</sub> receptor}}
{{PBB|geneid=3351}}
'''-{5-HT<sub>1B</sub>}- receptor''' (''5-hidroksitriptaminski receptor 1B'') je [[protein]] koji je kod ljudi kodiran {{Gene|HTR1B}} [[gen]]om.<ref name="pmid1348246">{{cite journal |vauthors=Jin H, Oksenberg D, Ashkenazi A, Peroutka SJ, Duncan AM, Rozmahel R, Yang Y, Mengod G, Palacios JM, O'Dowd BF | title = Characterization of the human 5-hydroxytryptamine1B receptor | journal = J. Biol. Chem. | volume = 267 | issue = 9 | pages = 5735–8 | year = 1992 | pmid = 1348246 | doi = | url = | issn = }}</ref><ref name="pmid11247661">{{cite journal |vauthors=Sanders AR, Cao Q, Taylor J, Levin TE, Badner JA, Cravchik A, Comeron JM, Naruya S, Del Rosario A, Salvi DA, Walczyk KA, Mowry BJ, Levinson DF, Crowe RR, Silverman JM, Gejman PV | title = Genetic diversity of the human serotonin receptor 1B (HTR1B) gene | journal = Genomics | volume = 72 | issue = 1 | pages = 1–14 | year = 2001 | pmid = 11247661 | doi = 10.1006/geno.2000.6411 | url = | issn = }}</ref> -{5-HT<sub>1B</sub>}- receptor je tip [[5-HT receptor]]a.<ref name="entrez">{{cite web | title = Entrez Gene: HTR1B 5-hydroxytryptamine (serotonin) receptor 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3351| accessdate = }}</ref>

== Distribucija u tkivu i funkcija ==
-{5-HT<sub>1B</sub>}- receptor deluje na [[centralni nervni sistem|CNS]], gde indukuje [[sinapsa|presinaptičku inhibiciju]] i utiče na ponašanje. On takođe ima vaskularne efekte, kao što je pulmonarna [[vazokonstrikcija]].

Blokiranje -{5-HT<sub>1B</sub>}- receptora povećava broj [[osteoblast]]a, koštanu masu, i brzinu formiranja kostiju.<ref name="pmid19041748">{{cite journal |vauthors=Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, Glorieux FH, Chiang CY, Zajac JD, Insogna KL, Mann JJ, Hen R, Ducy P, Karsenty G | title = Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum | journal = Cell | volume = 135 | issue = 5 | pages = 825–37 | year = 2008 | pmid = 19041748 | pmc = 2614332 | doi = 10.1016/j.cell.2008.09.059 | url = | issn = | laysummary = http://www.medpagetoday.com/Endocrinology/Osteoporosis/11923 | laysource = medpagetoday.com }}</ref>

== Ligandi ==
{{columns-list|2|
=== Agonisti ===
* [[ergotamin]] ([[Vazokonstrikcija|vazokonstriktor]] kod migrene)
* [[sumatriptan]] (vazokonstriktorkod migrene)
* [[zolmitriptan]]
* [[5-Karboksamidotriptamin]]
* -{[[CGS-12066A]]}-
* -{CP-93,129}- (periferno delujući)
* -{[[CP-94,253]]}-
* -{CP-135,807}- (mešoviti -{5-HT<sub>1B/1D</sub>}- agonist)
* -{RU-24969}- (mešoviti -{5-HT<sub>1A/1B</sub>}- agonist)

=== Antagonisti i inverzni agonisti ===
* [[metiotepin]] ([[antipsihotik]])
* [[johimbin]] ([[afrodizijak]])
* [[metergolin]]
* [[izamoltan]]
* -{[[AR-A000002]]}-<ref>{{cite journal | last1 = Hudzik | first1 = TJ | last2 = Yanek | first2 = M | last3 = Porrey | first3 = T | last4 = Evenden | first4 = J | last5 = Paronis | first5 = C | last6 = Mastrangelo | first6 = M | last7 = Ryan | first7 = C | last8 = Ross | first8 = S | last9 = Stenfors | first9 = C | title = Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist. | url = https://archive.org/details/sim_journal-of-pharmacology-and-experimental-therapeutics_2003-03_304_3/page/1072 | journal = The Journal of pharmacology and experimental therapeutics | volume = 304 | issue = 3 | pages = 1072–84 | year = 2003 | pmid = 12604684 | doi = 10.1124/jpet.102.045468 }}</ref>
* -{[[SB-216,641]]}-
* -{SB-224,289}- (inverzni agonist)<ref>{{cite journal | last1 = Selkirk | first1 = JV | last2 = Scott | first2 = C | last3 = Ho | first3 = M | last4 = Burton | first4 = MJ | last5 = Watson | first5 = J | last6 = Gaster | first6 = LM | last7 = Collin | first7 = L | last8 = Jones | first8 = BJ | last9 = Middlemiss | first9 = DN | title = SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity. | url = https://archive.org/details/sim_british-journal-of-pharmacology_1998-09_125_1/page/202 | journal = British journal of pharmacology | volume = 125 | issue = 1 | pages = 202–8 | year = 1998 | pmid = 9776361 | pmc = 1565605 | doi = 10.1038/sj.bjp.0702059 }}</ref>
* -{SB-236,057}- (inverzni agonist)<ref>{{cite journal | last1 = Roberts | first1 = C | last2 = Watson | first2 = J | last3 = Price | first3 = GW | last4 = Middlemiss | first4 = DN | title = SB-236057-A: a selective 5-HT1B receptor inverse agonist. | journal = CNS drug reviews | volume = 7 | issue = 4 | pages = 433–44 | year = 2001 | pmid = 11830759 }}</ref>
}}
== Genetika ==
Ovaj protein je kod ljudi kodiran {{Gene|HTR1B}} [[gen]]om.

Genetička varijanta u promotorskom regionu, -{''[[A-161T]]''}-, je bila ispitana u pogledu inpakta na crte ličnosti, i utvrđeno je da nema uticaja.<ref name="pmid14504413">{{cite journal |vauthors=Tsai SJ, Wang YC, Chen JY, Hong CJ | title = Allelic variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A-161T) and personality traits | journal = Neuropsychobiology | volume = 48 | issue = 2 | pages = 68–71 | year = 2003 | pmid = 14504413 | doi = 10.1159/000072879 | url =  }}</ref>

== Vidi još ==
* [[5-HT1 receptor|-{5-HT<sub>1</sub>}- receptor]]
* [[5-HT receptor|-{5-HT}- receptor]]

== Literatura ==
{{reflist|2}}

== Dodatna literatura ==
{{Литература | 2}}
{{PBB Further reading
| citations =
*{{cite journal  |vauthors=Olivier B, van Oorschot R |title=5-HT1B receptors and aggression: a review. |journal=Eur. J. Pharmacol. |volume=526 |issue= 1–3 |pages= 207–17 |year= 2006 |pmid= 16310769 |doi= 10.1016/j.ejphar.2005.09.066 }}
*{{cite journal  |vauthors=Hamblin MW, Metcalf MA, McGuffin RW, Karpells S |title=Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 2 |pages= 752–9 |year= 1992 |pmid= 1315531 |doi=10.1016/0006-291X(92)90654-4  }}
*{{cite journal  |vauthors=Veldman SA, Bienkowski MJ |title=Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype |journal=Mol. Pharmacol. |volume=42 |issue= 3 |pages= 439–44 |year= 1992 |pmid= 1328844 |doi=  }}
*{{cite journal  |author1=Demchyshyn L |author2=Sunahara RK |author3=Miller K |display-authors=etal |title=A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5522–6 |year= 1992 |pmid= 1351684 |doi=10.1073/pnas.89.12.5522  | pmc=49324  }}
*{{cite journal  |author1=Levy FO |author2=Gudermann T |author3=Perez-Reyes E |display-authors=etal |title=Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7553–62 |year= 1992 |pmid= 1559993 |doi=  }}
*{{cite journal  |author1=Weinshank RL |author2=Zgombick JM |author3=Macchi MJ |display-authors=etal |title=Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3630–4 |year= 1992 |pmid= 1565658 |doi=10.1073/pnas.89.8.3630  | pmc=48922  }}
*{{cite journal  |author1=Mochizuki D |author2=Yuyama Y |author3=Tsujita R |display-authors=etal |title=Cloning and expression of the human 5-HT1B-type receptor gene |journal=Biochem. Biophys. Res. Commun. |volume=185 |issue= 2 |pages= 517–23 |year= 1992 |pmid= 1610347 |doi=10.1016/0006-291X(92)91655-A  }}
*{{cite journal  |vauthors=Nöthen MM, Erdmann J, Shimron-Abarbanell D, Propping P |title=Identification of genetic variation in the human serotonin 1D beta receptor gene |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 2 |pages= 1194–200 |year= 1995 |pmid= 7802650 |doi=10.1006/bbrc.1994.2792  }}
*{{cite journal  |author1=Ng GY |author2=George SR |author3=Zastawny RL |display-authors=etal |title=Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition |journal=Biochemistry |volume=32 |issue= 43 |pages= 11727–33 |year= 1993 |pmid= 8218242 |doi=10.1021/bi00094a032  }}
*{{cite journal  |author1=Bouchelet I |author2=Cohen Z |author3=Case B |display-authors=etal |title=Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels |journal=Mol. Pharmacol. |volume=50 |issue= 2 |pages= 219–23 |year= 1996 |pmid= 8700126 |doi=  }}
*{{cite journal  |vauthors=Varnäs K, Hall H, Bonaventure P, Sedvall G |title=Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H]GR 125743 |journal=Brain Res. |volume=915 |issue= 1 |pages= 47–57 |year= 2001 |pmid= 11578619 |doi=10.1016/S0006-8993(01)02823-2  }}
*{{cite journal  |author1=Salim K |author2=Fenton T |author3=Bacha J |display-authors=etal |title=Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15482–5 |year= 2002 |pmid= 11854302 |doi= 10.1074/jbc.M201539200 }}
*{{cite journal  |vauthors=Hasegawa Y, Higuchi S, Matsushita S, Miyaoka H |title=Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2 |journal=Journal of neural transmission (Vienna, Austria : 1996) |volume=109 |issue= 4 |pages= 513–21 |year= 2002 |pmid= 11956970 |doi= 10.1007/s007020200042 }}
*{{cite journal  |author1=Hawi Z |author2=Dring M |author3=Kirley A |display-authors=etal |title=Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample |journal=Mol. Psychiatry |volume=7 |issue= 7 |pages= 718–25 |year= 2003 |pmid= 12192616 |doi= 10.1038/sj.mp.4001048 }}
*{{cite journal  |author1=Strausberg RL |author2=Feingold EA |author3=Grouse LH |display-authors=etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |author1=Huang YY |author2=Oquendo MA |author3=Friedman JM |display-authors=etal |title=Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism |journal=Neuropsychopharmacology |volume=28 |issue= 1 |pages= 163–9 |year= 2003 |pmid= 12496953 |doi= 10.1038/sj.npp.1300000 }}
*{{cite journal  |author1=Quist JF |author2=Barr CL |author3=Schachar R |display-authors=etal |title=The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder |journal=Mol. Psychiatry |volume=8 |issue= 1 |pages= 98–102 |year= 2003 |pmid= 12556913 |doi= 10.1038/sj.mp.4001244 }}
*{{cite journal  |vauthors=Sinha R, Cloninger CR, Parsian A |title=Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholism |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=121 |issue= 1 |pages= 83–8 |year= 2003 |pmid= 12898580 |doi= 10.1002/ajmg.b.20064 }}
}}
{{Литература крај}}

== Spoljašnje veze ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2312 | title = 5-HT<sub>1B</sub> | accessdate =  | date =  | format =  | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages =  | language =  | archiveurl = https://web.archive.org/web/20160304202908/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2312 | archivedate = 04. 03. 2016 | quote =  | url-status =  }}
{{-}}
{{G protein spregnuti receptori-lat}}
{{Serotonergici-lat}}

{{normativna kontrola}}

[[Категорија:Г протеин спрегнути рецептори]]
[[Категорија:Биологија хиперкинетичког поремећаја]]