Peptidilprolilna izomeraza
(преусмерено са Ciklofilin)
| Peptidilprolilna izomeraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 5.2.1.8 | ||||||||
| CAS broj | 95076-93-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Peptidilprolilna izomeraza (EC 5.2.1.8, PPIaza, ciklofilin, peptid vezana izomeraza, peptidilna-prolil cis-trans izomeraza) je enzim sa sistematskim imenom peptidilprolin cis-trans-izomeraza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
- peptidilnaprolin (omega = 180) peptidilnaprolin (omega = 0)
Prvi pronađeni tip ovog enzima je proteinski ciklofilin, koji vezuje imunosupresant ciklosporin A. Postoje druge distinktne familije. Među njima su FK-506 vezujući proteini (FKBP).
Reference
[уреди | уреди извор]- ^ Fischer, G. & Bang, H. (1985). „The refolding of urea-denatured ribonuclease A is catalyzed by peptidyl-prolyl cis-trans isomerase”. Biochim. Biophys. Acta. 828: 39—42. PMID 3882150.
- ^ Fischer, G., Bang, H. and Mech, C. (1984). „[Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides]”. Biomed. Biochim. Acta. 43: 1101—1111. PMID 6395866.
- ^ Fischer, G., Wittmann-Liebold, B., Lang, K., Kiefhaber, T. and Schmid, F.X. (1989). „Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins”. Nature. 337: 476—478. PMID 2492638.
- ^ Takahashi, N., Hayano, T. and Suzuki, M. (1989). „Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin”. Nature. 337: 473—475. PMID 2644542.
- ^ Hennig, L., Christner, C., Kipping, M., Schelbert, B., Rucknagel, K.P., Grabley, S., Kullertz, G. and Fischer, G. (1998). „Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone”. Biochemistry. 37: 5953—5960. PMID 9558330.
- ^ Fischer, G. (1994). „Peptidyl-prolyl cis/trans isomerases and their effectors”. Angew. Chem. Int. Ed. Engl. 33: 1415—1436.
- ^ Harrison, R.K. & Stein, R.L. (1990). „Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes”. Biochemistry. 29: 3813—3816. PMID 1693856.
- ^ Eisenmesser, E.Z., Bosco, D.A., Akke, M. and Kern, D. (2002). „Enzyme dynamics during catalysis”. Science. 295: 1520—1523. PMID 11859194.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Peptidylprolyl+isomerase на US National Library of Medicine Medical Subject Headings (MeSH)
