ENCODE

ENCODE
Kontent
Opis	Baza podataka celog genoma
Kontakt
Istraživački centar	Kalifornijski univerzitet Santa Kruz
Laboratorija	Center za biomolekularne nauke i inženjestvo
Autori	Brian J Raney
Primarni citat	PMID 21037257
Pristup
Veb stranica	encodeproject.org
Alati
Razno

Enciklopedija DNK elemenata (ENCODE) je javni istraživački konzorcijum^[2] koji je uspostavio USA|američki Nacionalni istraživački institut ljudskog genoma (NHGRI) septembra 2003.^[1]^[3]^[4]^[5] Njegov primarni cilj je da se nađu svi funkcionalni elementi ljudskog genoma.^[6] Podaci generisani u okviru ovog projekta se deponuju u javne baze podataka.

Inicijalni rezultati projekta su objavljeni 5. septembra 2012. u koordiniranoj grupi od 30 članaka objavljenih u žurnalima Nature (6 publikacija), Genome Biology (18 publikacija), i Genome Research (6 publikacija).^[7]^[8] U publikaciji sa pregledom projekta se navodi da su poznate biohemijske funkcije za 80% ljudskog genoma.^[9]^[10] Znatan deo funkcionalne nekodirajuće DNK učestvuje u regulaciji ekspresije kodirajućih gena.^[9] Izražavanje kodirajućih gena je kontrolisano višestrukim rebulatornim mestima, koja mogu da budu locirana u blizini ili na znatnoj razdaljini od gena. Ovi resultati demonstriraju da je regulacija gena daleko kompleksnija nego što se ranije verovalo.^[11]

Reference

^ ^а ^б Raney, BJ; Cline, MS; Rosenbloom, KR; Dreszer, TR; Learned, K; Barber, GP; Meyer, LR; Sloan, CA; Malladi, VS; Roskin KM; Suh BB; Hinrichs AS; Clawson H; Zweig AS; Kirkup V; Fujita PA; Rhead B; Smith KE; Pohl A; Kuhn RM; Karolchik D; Haussler D; Jim Kent (2011). „ENCODE whole-genome data in the UCSC genome browser (2011 update)”. Nucleic Acids Research. 39 (Database issue): D871—5. PMC 3013645 . PMID 21037257. doi:10.1093/nar/gkq1017.
^ Maher, B. (2012). „ENCODE: The human encyclopaedia”. Nature. 489 (7414): 46—8. PMID 22962707. doi:10.1038/489046a.
^ ENCODE Project Consortium (2011). Becker PB, ур. „A User's Guide to the Encyclopedia of DNA Elements (ENCODE)”. PLoS Biology. 9 (4): e1001046. PMC 3079585 . PMID 21526222. doi:10.1371/journal.pbio.1001046.
^ Consortium, ENCODE Project; Birney, Ewan; Stamatoyannopoulos, JA; Dutta, A; Guigó, R; Gingeras, TR; Margulies, EH; Weng, Z; Snyder, M; Dermitzakis ET; et al. (2007). „Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project”. Nature. 447 (7146): 799—816. Bibcode:2007Natur.447..799B. PMC 2212820 . PMID 17571346. doi:10.1038/nature05874.
^ Guigó, R; Flicek, P; Abril, JF; Reymond, A; Lagarde, J; Denoeud, F; Antonarakis, S; Ashburner, M; Bajic, VB; Ewan Birney; Castelo R; Eyras E; Ucla C; Gingeras TR; Harrow J; Hubbard T; Lewis SE; Reese MG (2006). „EGASP: The human ENCODE Genome Annotation Assessment Project”. Genome Biology. 7: S2. PMC 1810551 . PMID 16925836. doi:10.1186/gb-2006-7-s1-s2.
^ National Human Genome Research Institute. „The ENCODE Project: ENCyclopedia Of DNA Elements”. U.S. National Institutes of Health.
^ „ENCODE project at UCSC”. ENCODE Consortium. Приступљено 5. 9. 2012.
^ Walsh, F. (5. 9. 2012). „Detailed map of genome function”. BBC News. Архивирано из оригинала 05. 09. 2012. г. Приступљено 6. 9. 2012.
^ ^а ^б Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M (2012). „An integrated encyclopedia of DNA elements in the human genome”. Nature. 489 (7414): 57—74. Bibcode:2012Natur.489...57T. PMID 22955616. doi:10.1038/nature11247.
^ Timmer, J. (10. 9. 2012). „Most of what you read was wrong: how press releases rewrote scientific history”. Staff / From the Minds of Ars. Ars Technica. Приступљено 10. 9. 2012.
^ Pennisi, E. (2012). „Genomics. ENCODE project writes eulogy for junk DNA”. Science. 337 (6099): 1159, 1161. PMID 22955811. doi:10.1126/science.337.6099.1159.

Vidi još

Spoljašnje veze

Званични веб-сајт
ENCODE project at the National Human Genome Research Institute
ENCODE/GENCODE project at the Wellcome Trust Sanger Institute
ENCODE-sponsored introductory tutorial
FactorBook

[Raney2011-1] а ^б Raney, BJ; Cline, MS; Rosenbloom, KR; Dreszer, TR; Learned, K; Barber, GP; Meyer, LR; Sloan, CA; Malladi, VS; Roskin KM; Suh BB; Hinrichs AS; Clawson H; Zweig AS; Kirkup V; Fujita PA; Rhead B; Smith KE; Pohl A; Kuhn RM; Karolchik D; Haussler D; Jim Kent (2011). „ENCODE whole-genome data in the UCSC genome browser (2011 update)”. Nucleic Acids Research. 39 (Database issue): D871—5. PMC 3013645 . PMID 21037257. doi:10.1093/nar/gkq1017.

[Maher_2012-2] Maher, B. (2012). „ENCODE: The human encyclopaedia”. Nature. 489 (7414): 46—8. PMID 22962707. doi:10.1038/489046a.

[3] ENCODE Project Consortium (2011). Becker PB, ур. „A User's Guide to the Encyclopedia of DNA Elements (ENCODE)”. PLoS Biology. 9 (4): e1001046. PMC 3079585 . PMID 21526222. doi:10.1371/journal.pbio.1001046.

[birney-4] Consortium, ENCODE Project; Birney, Ewan; Stamatoyannopoulos, JA; Dutta, A; Guigó, R; Gingeras, TR; Margulies, EH; Weng, Z; Snyder, M; Dermitzakis ET; et al. (2007). „Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project”. Nature. 447 (7146): 799—816. Bibcode:2007Natur.447..799B. PMC 2212820 . PMID 17571346. doi:10.1038/nature05874.

[5] Guigó, R; Flicek, P; Abril, JF; Reymond, A; Lagarde, J; Denoeud, F; Antonarakis, S; Ashburner, M; Bajic, VB; Ewan Birney; Castelo R; Eyras E; Ucla C; Gingeras TR; Harrow J; Hubbard T; Lewis SE; Reese MG (2006). „EGASP: The human ENCODE Genome Annotation Assessment Project”. Genome Biology. 7: S2. PMC 1810551 . PMID 16925836. doi:10.1186/gb-2006-7-s1-s2.

[urlENCODE_Project-6] National Human Genome Research Institute. „The ENCODE Project: ENCyclopedia Of DNA Elements”. U.S. National Institutes of Health.

[7] „ENCODE project at UCSC”. ENCODE Consortium. Приступљено 5. 9. 2012.

[8] Walsh, F. (5. 9. 2012). „Detailed map of genome function”. BBC News. Архивирано из оригинала 05. 09. 2012. г. Приступљено 6. 9. 2012.

[pmid22955616-9] а ^б Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M (2012). „An integrated encyclopedia of DNA elements in the human genome”. Nature. 489 (7414): 57—74. Bibcode:2012Natur.489...57T. PMID 22955616. doi:10.1038/nature11247.

[url_Ars_Technica-10] Timmer, J. (10. 9. 2012). „Most of what you read was wrong: how press releases rewrote scientific history”. Staff / From the Minds of Ars. Ars Technica. Приступљено 10. 9. 2012.

[pmid22955811-11] Pennisi, E. (2012). „Genomics. ENCODE project writes eulogy for junk DNA”. Science. 337 (6099): 1159, 1161. PMID 22955811. doi:10.1126/science.337.6099.1159.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]