Harrison's Principles of Internal Medicine, 17e Part Nine: Disorders of the Cardiovascular System > Section 3: Disorders of Rhythm >
Atrioventricular Conduction Disease Sections: Atrioventricular
Conduction Disease, Structure and
Physiology of the AV Node, Etiology of
AV Conduction Disease, Electrocardiography
and Electrophysiology of AV Conduction Block, Diagnostic Testing, Atrioventricular
Conduction Block: Treatment. Topics Discussed: adenosine; anti-arrhythmia agents; arrhythmias; atrioventricular block; atrioventricular node; bradycardia; congenital complete atrioventricular heart block; electrocardiogram; first degree atrioventricular block; lithium; mobitz type i incomplete atrioventricular block; second degree atrioventricular block.
Excerpt:
" The AV conduction axis is structurally complex, involving the
atria and ventricles as well as the AV node. Unlike the SA node,
the AV node is a subendocardial structure originating in the transitional
zone, which is composed of aggregates of cells in the posterior-inferior
right atrium. Superior, medial, and posterior transitional atrionodal
bundles converge on the compact AV node. The compact AV node (~1 x 3 x 5
mm) is located at the apex of the triangle of Koch, which is defined
by the coronary sinus ostium posteriorly, the septal tricuspid valve
annulus anteriorly, and the tendon of Todaro superiorly. The compact
AV node continues as the penetrating AV bundle where it immediately traverses
the central fibrous body and is in close proximity to the aortic,
mitral, and tricuspid valve annuli; thus, it is subject to injury
in the setting of valvular heart disease or its surgical treatment.
The penetrating AV bundle continues through the annulus fibrosis
and emerges along the ventricular septum adjacent to the membranous
septum as the bundle of His. The right bundle branch (RBB) emerges
from the distal AV bundle in a band that traverses the right ventricle
(moderator band). In contrast, the left bundle..."
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