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email:
boontin.chua@imb.a-star.edu.sg
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Boon Tin Chua |
Boon Tin graduated with B.Sc (Hons in Biochemistry) from Imperial College of Science, Technology and Medicine in 1998. She received her PhD training at the Institute of Molecular and Cell Biology, Singapore with Dr Peng Li. During which, she demonstrated the translocation of cofilin, an actin binding protein, to mitochondria resulting in apoptosis initiation using differential display of cellular proteomics and also identified an alternate regulation of caspases by calpain, calcium activated protease, using an in vitro biochemical assay.
Upon graduation in 2004, Boon Tin was awarded Post-doctoral training Fellowship by Cancer Research UK, expanding her apoptosis background with Dr Julian Downward’s Signal Transduction Laboratory in Lincoln’s Inn Fields, London. During her post-doctoral training, she set up a human kinome siRNA library screen to identify Akt regulators.
She joined Singapore Oncogenome Project (SOG) in March 2007 as a research fellow characterizing somatic mutations identified on tyrosine kinases (TKs) in cancer cells. In 2008, she was appointed the project leader of SOG with Prof Axel Ullrich as the scientific advisor and mentor. She was also awarded the inaugural A*STAR-NKTH joint grant in 2009 for the development of small molecule inhibitors against TKs. Her current research focuses on exploring novel tyrosine kinases as anti-cancer therapeutics with the aim to develop tyrosine kinase inhibitor for cancer treatment.
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Prof Axel Ullrich is a renowned scientist known for his contribution to cancer research leading to two cancer therapies namely Herceptin and Sunitinib for treatment of Her2 overexpressing breast cancer and advance renal cell carcinoma and GIST respectively. He is the Director of Molecular Biology at Max Planck Institute of Biochemistry at Martinsried since 1988 and founded 3 biotech companies.
Professor Ullrich is a recipient for numerous international awards for his major contributions to Science. Recently, he is awarded the Wolf Prize 2010, an international award that is presented to living scientists and artists for “achievements in the interest of mankind and friendly relations among peoples... irrespective of nationality, race, color, religion, sex or political views.” His scientific work has been published in more than 500 articles in international journals and with over 58000 citations. He is one of the ten most cited scientists over the past 25 years worldwide.
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