Bacterial Cell-to-Cell Communication: Role in Virulence and PathogenesisMany bacterial diseases are caused by organisms growing together as communities or biofilms. These microorganisms have the capacity to coordinately regulate specific sets of genes by sensing and communicating amongst themselves utilizing a variety of signals. This book examines the mechanisms of quorum sensing and cell-to-cell communication in bacteria and the roles that these processes play in regulating virulence, bacterial interactions with host tissues, and microbial development. Recent studies suggest that microbial cell-to-cell communication plays an important role in the pathogenesis of a variety of disease processes. Furthermore, some bacterial signal molecules may possess immunomodulatory activity. Thus, understanding the mechanisms and outcomes of bacterial cell-to-cell communication has important implications for appreciating host-pathogen interactions and ultimately may provide new targets for antimicrobial therapies that block or interfere with these communication networks. |
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Bacterial Cell-to-Cell Communication: Role in Virulence and Pathogenesis Donald R. Demuth,Richard Lamont No preview available - 2006 |
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Acad activity addition aggregation analysis aureus autoinducer bacteria Bacteriol binding biofilm biofilm formation C-signal caused cells cholerae colonization communication competence complex compounds conjugation culture demonstrated density detected disease domain effect EHEC encoding environment Escherichia coli et al evidence Figure function gene expression genetic gingivalis gordonii growth harveyi host human identified Immun important increased indicated induced infection inhibit interactions involved kinase lactone LasR luxS mechanism Microbiol Molec motility mutant Myxococcus Myxococcus xanthus Natn natural observed operon oral organisms pathway peptide plasmid presence Proc production promoter protein Pseudomonas aeruginosa quorum sensing recently receptor regulation regulatory regulon reported repression response role secretion sequence showed shown signal signal molecule similar specific Staphylococcus strain Streptococcus structure studies suggesting surface synthesis tion transcription TraR Vibrio Vibrio cholerae virulence virulence factors wild-type