Atropine / diphenoxylate Pregnancy and Breastfeeding Warnings
Brand names: Logen, Lomanate, Lomocot, Lomotil, Lonox, Vi-Atro
Medically reviewed by Drugs.com. Last updated on Mar 4, 2024.
Atropine / diphenoxylate Pregnancy Warnings
This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus.
US FDA pregnancy category: C
Comments:
-This medication may cause respiratory depression in newborn infants.
-Do not give at, or near, term.
Animal studies showed effects on fertility and decreased maternal weight at 50 times the human dose; a small animal study did not show embryotoxicity, fetotoxicity, or teratogenic effects. There are no controlled data in human pregnancy.
US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Atropine / diphenoxylate Breastfeeding Warnings
Caution is recommended.
Excreted into human milk: Yes
Comments:
-Atropine is excreted in breast milk.
-The major metabolite of diphenoxylate (diphenoxylic acid) may be excreted in breast milk.
-Infants of nursing mothers taking this medication may exhibit some of the side effects of the drug.
See also
References for pregnancy information
- "Product Information. Lomotil (atropine-diphenoxylate)." Searle
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
References for breastfeeding information
- "Product Information. Lomotil (atropine-diphenoxylate)." Searle
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.