Current database content for version 2024.2 released 26 June 2024.
Target Class | Number of human targets‡ |
7TM receptors | 399 |
G protein-coupled receptors including orphans | 394 |
Orphan G protein-coupled receptors* | 122 |
Other 7TM proteins | 5 |
Nuclear hormone receptors | 48 |
Catalytic receptors | 253 |
Ligand-gated ion channels | 81 |
Voltage-gated ion channels | 144 |
Other ion channels | 53 |
Enzymes | 1305 |
Transporters | 555 |
Other protein targets | 245 |
Total number of targets | 3083 |
Chemical Class | Number of ligands |
Synthetic organics | 9023 |
Metabolites | 513 |
Endogenous peptides | 818 |
Other peptides including synthetic peptides | 1517 |
Natural Products | 430 |
Antibodies | 393 |
Inorganics | 39 |
Approved drugs | 1995 |
Withdrawn drugs | 110 |
Drugs with INNs | 3483 |
Labelled ligands | 649 |
Total number of ligands | 12733 |
Category | Count in database |
Number of curated binding constants | 20950 |
Number of binding constants from large-scale screens | 31207 |
Number of references | 45850 |
Human targets with curated interactions | 1995 |
Human targets with quantitative interactions | 1744 |
Human targets with quantitative interactions with CIDs | 1575 |
Human targets of approved drugs | 746 |
Human primary targets of approved drugs | 350 |
Approved drugs with quantitative interactions | 1133 |
Ligands with target interactions | 10511 |
Ligands with quantitative interactions | 9293 |
Ligands with CID and quantitative interactions | 7866 |
Ligands with clinical use summary | 3771 |
Approved drugs with clincial use summary | 1985 |
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‡ Measured by the number of distinct human UniProt entries included in the database for a given target class.
* Orphans are defined as proteins having similarity to receptors but whose endogenous ligands have not yet been conclusively identified.