| Entry |
|
|---|
| Name |
Pyrimethamine (JAN/USP/INN);
Daraprim (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C12H13ClN4
|
|---|
| Exact mass |
248.0829
|
|---|
| Mol weight |
248.71
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiparasitic
DG01932 Antifolate, antiprotozoal
|
|---|
| Remark |
|
|---|
| Efficacy |
Antimalarial |
|---|
| Disease |
|
|---|
| Comment |
Diaminopyrimidine derivative
|
|---|
| Target |
dihydrofolate reductase [KO: K13998] |
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
P01 ANTIPROTOZOALS
P01B ANTIMALARIALS
P01BD Diaminopyrimidines
P01BD01 Pyrimethamine
D00488 Pyrimethamine (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
Antiparasitics
Antiprotozoals
Pyrimethamine
D00488 Pyrimethamine (JAN/USP/INN)
Pyrimethamine
D00488 Pyrimethamine (JAN/USP/INN)
Drug groups [BR:br08330]
Antiparasitic
DG01932 Antifolate, antiprotozoal
D00488 Pyrimethamine
Antimicrobials [BR:br08307]
Antiparasitics
Antmalarials
Diaminopyrimidine
D00488 Pyrimethamine (JAN/USP/INN) <US>
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 17
1 C8y C 26.0400 -18.0659
2 C8y C 24.8327 -18.7949
3 C8y C 27.2938 -18.7892
4 C8y C 26.0691 -16.6428
5 C8x C 24.8794 -20.2063
6 C8x C 23.5787 -18.0776
7 N5x N 28.5420 -18.0717
8 C1b C 27.2938 -20.2356
9 N5x N 27.2938 -15.8846
10 N1a N 25.0776 -16.0713
11 C8x C 23.5728 -20.9762
12 C8x C 22.3539 -18.7892
13 C8y C 28.5537 -16.6021
14 C8y C 22.3248 -20.2530
15 N1a N 29.4868 -15.9780
16 X Cl 21.1933 -20.9470
17 C1a C 28.5090 -20.9360
BOND 18
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 2
9 4 10 1
10 5 11 1
11 6 12 2
12 7 13 2
13 11 14 2
14 13 15 1
15 14 16 1
16 9 13 1
17 12 14 1
18 8 17 1
|
|---|
