| Entry |
|
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| Name |
Omeprazole sodium (USAN);
Losec sodium (TN) |
|---|
| Formula |
C17H18N3O3S. Na
|
|---|
| Exact mass |
367.0967
|
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| Mol weight |
367.40
|
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| Structure |
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| Simcomp |
|
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| Class |
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00020): | D00455<JP/US> D05261<JP> D05259<US> |
|
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| Efficacy |
Antisecretory (gastric acid), Proton pump inhibitor |
|---|
| Comment |
Benzimidazole derivative
|
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| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2C19 [HSA: 1557]; CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BC Proton pump inhibitors
A02BC01 Omeprazole
D01207 Omeprazole sodium (USAN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG00020 Omeprazole
D01207 Omeprazole sodium
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG00020 Omeprazole
D01207 Omeprazole sodium
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00020 Omeprazole
D01207 Omeprazole sodium
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
ATPase
ATP4
D01207 Omeprazole sodium (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01207
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG00020 Omeprazole
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG00020 Omeprazole
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00020 Omeprazole
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 25
1 C8x C 22.6800 -19.3200
2 C8y C 22.6800 -20.7200
3 C8x C 23.9400 -21.4200
4 C8y C 25.1300 -20.7200
5 C8y C 25.1300 -19.3200
6 C8x C 23.9400 -18.6200
7 N5x N 26.4600 -21.1400
8 C8y C 27.3000 -20.0200
9 N4x N 26.4600 -18.9000 #-
10 S4a S 28.7000 -20.0200
11 O2a O 21.4200 -21.4200
12 C1a C 20.2300 -20.7200
13 C1b C 29.4000 -21.2100
14 O3c O 29.4000 -18.8300
15 C8y C 30.8000 -21.2100
16 C8y C 31.5000 -22.4000
17 C8y C 32.9000 -22.4000
18 C8y C 33.6000 -21.2100
19 C8x C 32.9000 -20.0200
20 N5x N 31.5000 -20.0200
21 C1a C 35.0000 -21.2100
22 O2a O 33.6000 -23.6600
23 C1a C 35.0000 -23.6600
24 C1a C 30.8000 -23.5900
25 Z Na 27.6500 -16.9400 #+
BOND 26
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 5 9 1
11 8 10 1
12 2 11 1
13 11 12 1
14 10 13 1
15 10 14 2
16 13 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 19 20 2
22 15 20 1
23 18 21 1
24 17 22 1
25 22 23 1
26 16 24 1
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