Search Results (4,388)

Background: The Measles–Rubella Microarray Patch (MR-MAP) is an important technology that is expected to reduce coverage and equity gaps for measles-containing vaccines (MCVs), reach zero-dose children, and contribute to elimination of measles and rubella. MR-MAPs are anticipated to be easier to deploy programmatically and could be delivered by lesser-trained health workers, thereby increasing immunization coverage. The most advanced MR-MAP has reached clinical proof-of-concept through a Phase I/II trial in the target population of infants and young children. The World Health Organization (WHO) and partners have developed the Phase III clinical trial framework for MR-MAPs presented in this article. Objectives and Methods: The purpose of such framework is to inform the considerations, design and approach for the pivotal clinical trial design, while considering the anticipated data requirements to inform regulatory approval, WHO prequalification, and policy decision. Results: The proposed Phase III trial would compare the immunogenicity and safety of an MR-MAP with MR vaccine delivered subcutaneously in 9- to 10-month-old infants. An analysis of non-inferiority (NI) of immunogenicity would occur six weeks after the first dose. Should regulatory agencies or policy makers require, a proportion of infants could receive a second dose of either the same or alternate MR vaccine presentation six months after the first dose, with those children returning six weeks after the second dose for a descriptive assessment of immunogenicity, and then followed up six months after the second dose for evaluation of safety and immunogenicity. It is anticipated that this proposed pivotal Phase III trial framework would generate the required clinical data for regulatory licensure and WHO prequalification (PQ) of MR-MAPs. However, the trial design would need to be reviewed and confirmed by a national regulatory authority (NRA) that will assess the product for regulatory licensure and the WHO PQ team. Additional research will likely be required to generate data on concomitant vaccine delivery, the safety and immunogenicity of MR-MAPs in other age groups such as children 1–5 years and infants younger than 9 months of age, and the impact of MR-MAPs on coverage and equity. Such studies could be conducted during or after clinical MR-MAP development. Full article

(1) Background: This study investigates the impact of social vulnerability, as quantified by the Social Vulnerability Index (SVI), on animal shelter intakes and adoptions, and the flow of animals between SVI groups at seven shelters within the United States. Understanding how social vulnerability influences these factors is crucial for developing targeted interventions to improve shelter outcomes and community support programs. (2) Methods: The research analyzed intake and adoption data from multiple animal shelters to assess the relationship between the social vulnerability at intake and adoption locations based on Census Tract obtained from addresses, focusing on comparison across strays, seized animals, and owner surrenders. Effect sizes were calculated to determine the magnitude and practical implications of these relationships. The study also examined the distribution of outcomes and reasons for animal surrender in relation to SVI levels. (3) Results: The analysis found that animals tended to enter shelters from areas of higher vulnerability while being adopted out to homes from all levels of vulnerability. Stray animals and those seized by authorities were more likely to come from high-SVI areas and showed a stronger disparity between intake and adoption SVI levels than owner surrenders. Racial/ethnic minority status and socioeconomic status were the components of the SVI that produced the strongest differences between intake and adoption vulnerability levels. Adoptions, however, were evenly distributed across different SVI levels, suggesting equitable access to adoption services. The study also identified that animals from high-SVI areas were not euthanized at higher rates compared to those from lower-SVI areas. (4) Conclusions: The findings highlight the need for further investigation into the high numbers of stray adult dogs in areas of communities that are most socially vulnerable as well as programs to address the volume of young animals originating from these areas. The equitable distribution of adoptions across SVI levels suggests that shelters are effectively engaging with socioeconomically and racially/ethnically diverse communities. Future research should focus on exploring the dynamics of stray animal intakes and enforcement patterns to enhance community and animal welfare initiatives. Full article

This paper discusses the development of district–university partnerships at the onset of a multi-year grant-funded initiative focused on leadership for equity. Using three illustrative partnership cases, we investigated district–university collaboration through the lens of mutualism, or the mutually beneficial nature of the relationship. Our data analysis revealed the following dynamics as important for the development of mutualism: shared commitment, shared ownership, new collaborative structures, reciprocal benefits, and boundary spanners. We approached partnerships as learning processes, and used a typology of interorganizational learning to understand better how these dynamics sustained the partnerships. Our study contributes to the field’s knowledge of the development of formal partnerships in general as well as of partnerships explicitly focused on equity specifically. Full article

It is well-believed that most trading activities tend to herd. Herding is an important topic in finance. It implies a violation of efficient markets and hence, suggests possibly predictable trading profits. However, it is hard to test such a hypothesis using aggregated data (as in the literature). In this paper, we obtain a proprietary data set that contains detailed trading information, and as a result, for the first time it allows us to validate this hypothesis. The data set contains all trades transacted in 2019 by all the brokers/dealers across all locations in Taiwan of all the equities (stocks, warrants, and ETFs). Given such data, in this paper, we use swarm intelligence to identify such herding behavior. In particular, we use two versions of swarm intelligence—Boids and PSO (particle swarm optimization)—to study the herding behavior. Our results indicate weak swarm among brokers/dealers. Full article

Accessibility to metro services is often evaluated based on the locations of stations. However, compared to the location of station itself, focusing on its entrances/exits offers a more accurate approach to assessing station supply and demand levels. Despite this, research focusing on the supply of and demand for metro services concerning metro entrances and exits remains limited. This study employed multi-source geospatial data from Xiamen, China, to examine the supply and demand dynamics of metro stations with a particular emphasis on entrances/exits. In the first phase, we treated entrances/exits as supply facilities and used land plot boundaries as the fundamental spatial units for accessibility calculations. Taking into account the layout characteristics of entrances/exits, along with the traffic generation of various land-use types, we employed the Gaussian two-step floating catchment area (G2SFCA) method to gauge the supply and demand levels of plots. Subsequently, we computed the spatial supply-and-demand relationships of station entrances/exits for both station-level and shared usage level of entrances/exits. We found that the accessibility from plots to entrances/exits diverged from previously observed spatial distribution trends, being higher in city centers, regional boundaries, and terminal stations and lower in transitional areas. Moreover, “metro accessibility” and the “imbalance index of entrances/exits” are associated with the primary functions of stations and the surrounding urban development; yet they exhibit spatial heterogeneity. The stations with a high value for “imbalanced index of entrances/exits” were always near some business parks, and “metro accessibility” seemed to be more easily affected by location factors. Based on two metrics, stations were categorized into four types, each displaying unique characteristics regarding location distributions, entrance/exit configurations, and commuting passenger sources. This research aims to identify the phenomenon of unfair transport in metro service from the perspective of their entrances, inform the optimization of metro station designs, and tailor planning recommendations, ultimately enhancing transport equity and contributing to sustainable urban built environments. Full article

China plays a significant role in the global fishing industry. The small-scale fisheries (SSFs) operating along its coast have made noteworthy and invaluable contributions in the areas of poverty alleviation, protein provision, social equity, and overall socioeconomic development. Coastal small-scale fishing management is a persistent challenge for all fishing nations, including China. In recent years, China has made significant strides in adopting scientific and refined approaches to fishery management in this sector. This paper provides an overview of the development of China’s coastal fishery management practices, including changes in policies, methods, and modes since the establishment of the People’s Republic of China (PRC) in 1949. To address these challenges, this research seeks to enhance the governance system of small-scale coastal fisheries by assessing values from three dimensions: society, economy, and ecology. Full article

The transport sector worldwide relies heavily on oil products, and private cars account for the largest share of passenger mobility in several countries. Public transport could represent an interesting alternative under many perspectives, including a decrease in traffic, pollutants, and climate emissions. However, for public transport to succeed, it should be attractive for final users, representing a viable alternative to private mobility. In this work, we analyse the spatial distribution of public transport service provision within two metropolitan cities, considering the three key dimensions of mobility, competitiveness, and accessibility of public transport. The results show that private car performs better than public transport in all scopes considered, and that performance indicators are highly variable among city areas, indicating inequalities in social and environmental sustainability in urban systems. The outcomes of the analysis provide interesting insights for policy makers and researchers that deal with similar topics, and can also be extended to other cities and countries. Full article

In this paper, we provide an overview of the research and literature on wild foods (i.e., edible plants that grow without human cultivation and/or animals harvested from their natural habit, i.e., food sourced from “hunting and gathering”) and their ability to assist food systems in becoming more sustainable and equitable. We begin with a discussion on the green revolution and the global capitalist food system that has been created and is dominated by large agribusinesses. Next, we turn to a brief discussion of how homogenizing the food system, as large agribusinesses have, leads to a corresponding loss of local culture. We then provide an overview of the main areas of wild food research, including nutrition, reducing food insecurity, the importance of cultural and shared knowledge, and sustainability. Our discussion stresses how focusing too heavily on the dichotomy of cultivated vs. wild food is problematic. Rather, lessons regarding health, sustainability, and equity can be learned from foragers, hunters and gathers. Full article

In this article, we examine how Black mothers devised strategies of resistance to prepare and protect their children during the Jim Crow era. Grounded in Black feminist standpoint theory, we rely on Black women’s own perspectives to understand how interlocking systems of oppression shaped their mothering experiences and practices. We use Dedoose cloud-based software to conduct a content analysis of 210 oral histories from two oral history repositories. Our grounded theory approach to data analysis entailed a multistage coding process, revealing that Black mothers strategized to provide their children choices in the present that would give them more freedom and opportunities in the future. We refer to this mothering practice as the cultivation of “freedom choices”. Freedom choices seek to minimize the hindrances and restraints that shape the choices available to Black children and to expand their available options. Black mothers fostered freedom choices by relying on both informal and formal education. They used informal education to teach their children restraint, resistance, and when to deploy which, and how to negotiate space. Black mothers facilitated their children’s educational pursuits in the face of structural barriers by (1) leveraging their own sweat equity, (2) tapping into their mutual aid networks, (3) challenging landowners, and (4) insisting on prioritizing their children’s education even when their partners did not. Full article

Cervical cancer is largely preventable through screening and treatment of cervical lesions. In the province of Ontario, South Asian women have some of the lowest rates of screening. The roles of service providers—those in healthcare and community services—and their interactions with screen-eligible people can greatly impact the uptake of screening. In our study, we used concept mapping (CM) to engage over 70 South Asian service users (i.e., those eligible for cervical screening) and service providers to identify a range of ideas and experiences that impact uptake of cervical screening for South Asian women, which were then rated by 45 participants in terms of ‘importance’ and ‘ease to address’ to encourage participation in cervical screening. Overall, ideas related to knowledge and education were rated as most important and easiest to address by both groups. Some differences were seen with South Asian service users valuing the importance of addressing ‘cultural beliefs and influences specific to sexual health’ more than service providers, while service providers valued the importance of addressing ‘lack of comfort and supportive relationships’ more than South Asian service users. Future interventions should target the knowledge and education needs of service users and increase service providers’ awareness of cultural beliefs and influences specific to sexual health. Full article

College-level introductory chemistry has a high impact for predicting students’ early success and long-term academic outcomes. Students from traditionally underserved communities are disproportionately held back in this course. To improve student success, the Supplemental Instruction (SI) program at a public four-year Hispanic-serving institution was revamped from a voluntary option to a co-requisite for the introductory chemistry course. The study evaluates the effectiveness of the new format of SI program and explores associated factors contributing to the impacts of the program. Students with or without SI were compared through multiple quantitative metrics, including course GPA, final exam score, DFW rate, and pass rate. Data analysis showed that students who completed SI with credit obtained 0.9 higher average course GPA than their counterparts and performed significantly better on all the other metrics. More importantly, the equity gaps between underserved and better-served students were narrowed down. Furthermore, students who took introductory chemistry with SI still obtained 0.3 higher average course GPA in their subsequent General Chemistry I course than those without it. The findings suggested that incorporating the SI into introductory chemistry as co-requisite is necessary and effective to improve students’ success and narrow down the equity gaps in gateway chemistry courses. Full article

Many women justify intimate partner violence (IPV), resulting in adverse health outcomes. This study investigates the relationship between household ownership of information and communication technologies (ICTs), along with the frequency of listening to the radio and watching television with women’s attitudes towards IPV in Bangladesh. The cross-sectional study analyzed a weighted sample of 20,032 women and used a multivariable logistic regression analysis to determine the association between predictor variables and outcome variables. The results showed that 19.47% of women justified wife beating for at least one reason. We found that household ownership of computers (AOR = 0.73 [95% CI = 0.57, 0.95]), women in households with three ICTs (AOR = 0.67 [95% CI = 0.47, 0.96]), and women who watched television at least once a week (AOR = 0.85 [95% CI = 0.74, 0.97]) were associated with decreased odds of justifying wife beating for at least one reason after adjustment for the frequency of reading newspaper or magazine, age, wealth, education, religion, and type of place of residence. The study suggests that not all ICTs affect women’s attitudes toward IPV equally. Computers and television were more influential than other ICTs. This finding suggests that awareness-building and educational programs targeted towards women via computer and television may deliver better outcomes about gender norms. Full article

Background/Objectives: Self-care experiences and understanding of coronary heart disease (CHD) play a pivotal role in the management of CHD and can contribute to positive health outcomes. This qualitative study aimed to explore the views and experiences of CHD patients, their families, and Indigenous leaders about self-care practices of CHD. Methods: A qualitative design employing semi-structured interviews and a focus group discussion was used. Employing purposive sampling, 49 respondents, comprising 30 patients, 10 family members, and 9 Indigenous leaders, were recruited and interviewed from April to September 2022. The data were analyzed using content analysis. Results: Five major categories were constructed: (1) inadequate knowledge and early symptom identification; (2) self-care activities for physical, psychosocial, and spiritual needs; (3) family and kinship support for self-care efforts; (4) barriers to self-care including physical, psychological, and access issues; and (5) health improvement expectations based on culturally sensitive health education. Conclusions: The study reveals significant gaps in knowledge about CHD and the identification of early symptoms among patients, families, and Indigenous leaders. Despite efforts to meet physical, psychosocial, and spiritual needs, self-care is hindered by various barriers, including limited access to healthcare and entrenched habits. The support from family and kinship systems is crucial for self-care. Participants expressed a strong desire for culturally tailored health education and better health control to improve heart health outcomes. Full article

Background/Objectives: A properly functioning musculoskeletal system is imperative for human well-being at every stage of life, including at an older age. This study’s aim was to assess the relationship between sociodemographic and physical functioning variables and the presence of individual musculoskeletal disorders (MSDs), MSD comorbidity, and multimorbidity, as well as to determine factors that are independent predictors of the presence of MSDs in people over 65 years old. Methods: This population-based study included 3701 participants aged 65 years and older. Data on individual MSDs addressed cervical and lumbosacral spine regions and degenerative joint disease (arthrosis). The subjects were categorized into four groups: those without any diseases; those with one MSD; those with two MSDs (comorbidities); and those with three MSDs (multimorbidities). The sociodemographic and physical functioning variables were analyzed. Results: Females were more likely to have MSDs (two: OR 1.95 and three: OR 2.25) than men. Elderly people aged 75 and above were 1.49 times more likely to have three MSDs. Elderly people with elementary school education were more likely to have MSDs (two: OR 1.34 and three: OR 2.06) than those with high school/university education. The low-income population was 2.47 times more likely to have three MSDs. Individuals with partial activity limitations because of health problems had greater chances of having one, two, or three MSDs (OR 1.60, 1.59, and 1.94, respectively), and elderly individuals with severe limitations had an OR of 1.43, 2.17, and 4.12, respectively. Individuals with some/many difficulties in walking up or down 12 steps were more likely to have MSDs (two: OR 2.26 and three: OR 2.28). Conclusions: The significant predictors of experiencing a single MSD, MSD comorbidity, or MSD multimorbidity include residing in the Serbian capital city and having limitations in activities due to health problems. A significant predictor of having a single MSD or MSD comorbidity is residing in the northern region of Serbia. A significant predictor of MSD comorbidity is residing in the southeastern region of Serbia. Significant predictors of MSD comorbidity or MSD multimorbidity include female gender, an elementary school educational level, and experiencing difficulty in walking up or down 12 steps. Significant predictors of MSD multimorbidity are being 75 years of age and above and having a lower income. Full article

The article presents findings from a survey study of K-12 teachers in the mid-Atlantic United States about their assessment practice. Guided by two frameworks related to teacher assessment literacy in practice and critical-data-driven decision-making, we investigated how teachers’ equity orientation is related to their perceived instructional usefulness of standardized assessments of learning and assessments for learning. Structural equation models revealed defensible contributions of equity orientation and assessment preparation and professional development, specifically, teachers’ motivations for joining the profession, preparation for reflective practice and equity-oriented practice, and beliefs about societal equality to their perceived usefulness of assessments. Findings provide empirical evidence to situate the role of and influences on assessment practices in supporting equitable learning environments. Full article